Response to Carbamazepine in a Case of Kleine-Levin Syndrome

Excerpt

To the Editor: A three-year-old boy was presented with 36–72-h attacks of unresponsiveness with normal vital signs and absence of specific neurological symptoms. Cerebrospinal fluid (CSF) studies, metabolic screening tests, anti-GAD antibodies, and thyroid tests were normal. In CSF, autoimmune encephalitis autoantibodies were not detected. He had ALT and AST elevations. Cytomegalovirus IgM and PCR were positive. EEG and brain MRI were normal. He recovered in 10 d. Within 7 mo, the patient experienced two more similar episodes. Since he had recurrent attacks, intravenous immunoglobulin and steroid treatments were administered. During the episodes, he became violent and disoriented. …