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01-04-2019 | Capsaicin | Original Article

Capsaicin supplementation increases time to exhaustion in high-intensity intermittent exercise without modifying metabolic responses in physically active men

Authors: Marcelo Conrado de Freitas, François Billaut, Valéria Leme Gonçalves Panissa, Fabricio Eduardo Rossi, Caique Figueiredo, Erico Chagas Caperuto, Fabio Santos Lira

Published in: European Journal of Applied Physiology | Issue 4/2019

Abstract

Purpose

The purpose of this study was to investigate the acute effect of capsaicin supplementation on performance and physiological responses during high-intensity intermittent exercise (HIIE).

Method

Thirteen physically active men (age = 24.4 ± 4.0 years; height = 176.4 ± 6.9 cm; body mass = 78.7 ± 13.8 kg; running training per week = 3.9 ± 0.9 h) performed an incremental running test to determine peak oxygen uptake (\(\dot {V}{{\text{O}}_{{\text{2Peak}}}}\)) and the speed associated with \(\dot {V}{{\text{O}}_{{\text{2Peak}}}}\) (s\(\dot {V}{{\text{O}}_{{\text{2Peak}}}}\)). Thereafter, subjects completed two randomized, double-blind HIIE (15s:15 s at 120% s\(\dot {V}{{\text{O}}_{{\text{2Peak}}}}\)) trials 45-min after consuming capsaicin (12 mg) or an isocaloric placebo. Time to exhaustion, blood lactate concentration, oxygen consumption during and 20 min post-exercise, energy expenditure, time spent above 90% of \(\dot {V}{{\text{O}}_{{\text{2Peak}}}}\), and the rate of perceived exertion were evaluated.

Results

There was no difference between capsaicin and placebo for any variable except time to exhaustion [capsaicin: 1530 ± 515 s (102 efforts) vs placebo: 1342 ± 446 s (89 efforts); p < 0.001].

Conclusion

In conclusion, capsaicin supplementation increased time to exhaustion in high-intensity intermittent exercise without modifying the metabolic response of exercise or the rate of perceived exertion in physically active men. Capsaicin could be used to increase the training load during specific exercise training sessions.

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Allen DG, Lamb GD, Westerblad H (2008) Impaired calcium release during fatigue. J Appl Physiol 104(1):296–305. https://doi.org/10.1152/japplphysiol.00908.2007 CrossRefPubMed

Billat VL, Slawinksi J, Bocquet V, Chassaing P, Demarle A, Koralsztein JP (2001) Very short (15 s–15 s) interval-training around the critical velocity allows middle-aged runners to maintain VO_2max for 14 minutes. Int J Sports Med 22(3):201–208. https://doi.org/10.1055/s-2001-16389 CrossRefPubMed

Bogdanis GC, Nevill ME, Boobis LH, Lakomy HK, Nevill AM (1995) Recovery of power output and muscle metabolites following 30 s of maximal sprint cycling in man. J Physiol 80:876–884

Borg G, Hassmen P, Lagerstrom M (1987) Perceived exertion related to heart rate and blood lactate during arm and leg exercise. Eur J Appl Physiol Occup Physiol 56(6):679–685CrossRefPubMed

Buchheit M, Laursen PB (2013a) High-intensity interval training, solutions to the programming puzzle. Part II: anaerobic energy, neuromuscular load and practical applications. Sports Med 43(10):927–954. https://doi.org/10.1007/s40279-013-0066-5 CrossRefPubMed

Buchheit M, Laursen PB (2013b) High-intensity interval training, solutions to the programming puzzle: Part I: cardiopulmonary emphasis. Sports Med 43(5):313–338. https://doi.org/10.1007/s40279-013-0029-x CrossRefPubMed

Conrado de Freitas, M, Cholewa JM, Freire RV, Carmo BA, Bottan J, Bratfich M et al (2017) Acute capsaicin supplementation improves resistance training performance in trained men. J Strength Cond Res. https://doi.org/10.1519/JSC.0000000000002109 CrossRef

De Freitas MC, Cholewa JM, Gobbo LA, de Oliveira JVNS, Lira FS, Rossi FE (2018) Acute capsaicin supplementation improves 1,500-m running time-trial performance and rate of perceived exertion in physically active adults. J Strength Cond Res 32(2):572–577PubMed

Di Prampero PE, Ferretti G (1999) The energetics of anaerobic muscle metabolism: a reappraisal of older and recent concepts. Respir Physiol 118(2–3):103–115CrossRefPubMed

Dupont G, Blondel N, Lensel G, Berthoin S (2002) Critical velocity and time spent at a high level of VO₂ for short intermittent runs at supramaximal velocities. Can J Appl Physiol 27(2):103–115CrossRefPubMed

Franchini E, Takito MY, Dal’Molin Kiss MA (2016) Performance and energy systems contributions during upper-body sprint interval exercise. J Exerc Rehabil 31(6):535–541. https://doi.org/10.12965/jer.1632786.393 CrossRef

Gaitanos GC, Williams C, Boobis LH, Brooksm S (1993) Human muscle metabolism during intermittent maximal exercise. J Appl Physiol 75(2):712–719. https://doi.org/10.1152/jappl.1993.75.2.712 CrossRefPubMed

Gastin PB (2001) Energy system interaction and relative contribution during maximal exercise. Sports Med 31(10):725–741CrossRefPubMed

Gillen JB, Percival ME, Ludzki A, Tarnopolsky MA, Gibala M (2013) Interval training in the fed or fasted state improves body composition and muscle oxidative capacity in overweight women. Obesity 21:2249–2255CrossRefPubMed

Helgerud J, Høydal K, Wang E, Karlsen T, Berg P, Bjerkaas M et al (2007) Aerobic high-intensity intervals improve VO_2max more than moderate training. Med Sci Sports Exerc 39(4):665–671. https://doi.org/10.1249/mss.0b013e3180304570 CrossRef

Homsher E, Kim B, Bobkova A, Tobacman LS (1996) Calcium regulation of thin filament movement in an in vitro motility assay. Biophys J 70(4):1881–1892. https://doi.org/10.1016/S0006-3495(96)79753-9 CrossRefPubMedPubMedCentral

Hopkins WG (2015) Individual responses made easy. J Appl Physiol 118(12):1444–1446. https://doi.org/10.1152/japplphysiol.00098.2015 CrossRefPubMed

Hsu YJ, Huang WC, Chiu CC, Liu YL, Chiu WC, Chiu CH et al (2016) Capsaicin supplementation reduces physical fatigue and improves exercise performance in mice. Nutrients 8(10):E648. https://doi.org/10.3390/nu8100648 CrossRefPubMed

Josse AR,. Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM (2010) Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab 7:65. https://doi.org/10.1186/1743-7075-7-65 CrossRef

Kawada T, Hagihara K, Iwai K (1986) Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J Nutr 116(7):1272–1278. https://doi.org/10.1093/jn/116.7.1272 CrossRefPubMed

Kazuya Y, Tonson A, Pecchi E, Dalmasso C, Vilmen C, Fur YL et al (2014) A single intake of capsiate improves mechanical performance and bioenergetics efficiency in contracting mouse skeletal muscle. Am J Physiol Endocrinol Metab 306(10):E1110–E1119. https://doi.org/10.1152/ajpendo.00520.2013 CrossRefPubMed

Keating SE, Johnson NA, Mielke GI, Coombes JS (2017) A systematic review and meta-analysis of interval training versus moderate-intensity continuous training on body adiposity. Obes Rev 18(8):943–964. https://doi.org/10.1111/obr.12536 CrossRefPubMed

Kim KM, Kawada T, Ishihara K, Inoue K, Fushiki T (1997) Increase in swimming endurance capacity of mice by capsaicin-induced adrenal catecholamine secretion. Biosci Biotechnol Biochem 61(10):1718–1723. https://doi.org/10.1271/bbb.61.1718 CrossRefPubMed

Kim KM, Kawada T, Ishihara K, Inoue K, Fushiki T (1998) Inhibition by a capsaicin antagonist (capsazepine) of capsaicin-induced swimming capacity increase in mice. Biosci Biotechnol Biochem 62(12):2444–2445CrossRefPubMed

Kuipers H, Verstappen FT, Keizer HA, Geurten P, Van Kranenburg G (1985) Variability of aerobic performance in the laboratory and its physiologic correlates. Int J Sports Med. 6(4):197–201. https://doi.org/10.1055/s-2008-1025839 CrossRefPubMed

Leppik JA, Aughey RJ, Medved I, Fairweather I, Carey MF, McKenna MJ (2004) Prolonged exercise to fatigue in humans impairs skeletal muscle Na⁺-K⁺-ATPase activity, sarcoplasmic reticulum Ca²⁺ release, and Ca²⁺ uptake. J Appl Physiol 97(4):1414–1423. https://doi.org/10.1152/japplphysiol.00964.2003 CrossRefPubMed

Leung FW (2014) Capsaicin as an anti-obesity drug. Prog Drug Res 68:171–179PubMed

Linari M, Brunello E, Reconditi M, Fusi L, Caremani M, Narayanan T et al (2015) Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments. Nature 528(7581):276–279. https://doi.org/10.1038/nature15727 CrossRefPubMed

Lira FS, dos Santos T, Caldeira RS, Inoue DY, Panissa VLG, Cabral-Santos C, Campos EZ, Rodrigues B, Monteiro P (2017) Short-term high- and moderate-intensity training modifies inflammatory and metabolic factors in response to acute exercise. Frontiers Physiol 8:856CrossRef

Little JP, Safdar A, Wilkin GP, Tarnopolsky MA, Gibala MJ (2010) A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms. J Physiol 588:1011–1022CrossRefPubMedPubMedCentral

Lotteau. S, Ducreux S, Romestaing C, Legrand C, Van Coppenolle F (2013) Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle. PLoS One 8(3):e58673. https://doi.org/10.1371/journal.pone.0058673 CrossRefPubMedPubMedCentral

Ludy MJ, Moore GE, Mattes RD (2012) The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Sens 37(2):103–121. https://doi.org/10.1093/chemse/bjr100 CrossRef

Luo Z, Ma L, Zhao Z, He H, Yang D, Feng X et al (2012) TRPV1 activation improves exercise endurance and energy metabolism through PGC-1alpha upregulation in mice. Cell Res 22(3):551–564. https://doi.org/10.1038/cr.2011.205 CrossRefPubMed

Margaria R, Edwards HT, Dill DB (1933) The possible mechanisms of contracting and paying the oxygen debt and the rôle of lactic acid in muscular contraction. Am J Physiol Leg Content 106(3):689–715. https://doi.org/10.1152/ajplegacy.1933.106.3.689%3E CrossRef

Milanovic Z, Sporis G, Weston M (2015) Effectiveness of high-intensity interval training (HIT) and continuous endurance training for VO_2max improvements: a systematic review and meta-analysis of controlled trials. Sports Med 45(10):1469–1481. https://doi.org/10.1007/s40279-015-0365-0 CrossRefPubMed

Milioni F, Zagatto AM, Barbieri RA, Andrade VL, Dos Santos JW, Gobatto CA et al (2017) Energy systems contribution in running-based anaerobic sprint test. Int J Sports Med 38(3):226–232. https://doi.org/10.1055/s-0042-117722 CrossRefPubMed

Oh TW, Ohta F (2003) Capsaicin increases endurance capacity and spares tissue glycogen through lipolytic function in swimming rats. J Nutr Sci Vitaminol 49(2):107–111CrossRefPubMed

Oh TW, Oh TW, Ohta F (2003) Dose-dependent effect of capsaicin on endurance capacity in rats. Br J Nutr 90(3):515–520CrossRefPubMed

Opheim MN, Rankin JW (2012) Effect of capsaicin supplementation on repeated sprinting performance. J Strength Cond Res 26(2):319–326. https://doi.org/10.1519/JSC.0b013e3182429ae5 CrossRefPubMed

Panissa VL, Fukuda DH, Caldeira RS, Gerosa-Neto J, Lira FS, Zagatto A et al (2018) Is oxygen uptake measurement enough to estimate energy expenditure during high-intensity intermittent exercise? Quantification of anaerobic contribution by different methods. Front Physiol 9:868. https://doi.org/10.3389/fphys.2018.00868 CrossRefPubMedPubMedCentral

Rockwell MS, Rankin JW, Dixon H (2003) Effects of muscle glycogen on performance of repeated sprints and mechanisms of fatigue. Int J Sport Nutr Exerc Metab 13(1):1–14CrossRefPubMed

Saunders PU, Pyne DB, Telford RD, Hawley JA (2004) Factors affecting running economy in trained distance runners. Sports Med 34(7):465–485. https://doi.org/10.2165/00007256-200434070-00005 CrossRefPubMed

Sawyer BJ, Tucker WJ, Bhammar DM, Ryder JR, Sweazea KL, Gaesser GA (2016) Effects of high-intensity interval training and moderate-intensity continuous training on endothelial function and cardiometabolic risk markers in obese adults. J App Physiol 121:279–288CrossRef

Shin KO, Moritani T (2007) Alterations of autonomic nervous activity and energy metabolism by capsaicin ingestion during aerobic exercise in healthy men. J Nutr Sci Vitaminol 53(2):124–132CrossRefPubMed

Smith-Ryan AE, Melvin MN, Wingfield HL (2015) High-intensity interval training: Modulating interval duration in overweight/obese men. Phys Sportsmed 43:107–113CrossRefPubMedPubMedCentral

Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y et al (2009) Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 89(1):45–50. https://doi.org/10.3945/ajcn.2008.26561 CrossRefPubMed

Szallasi A, Blumberg PM (1999) Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 51(2):159–212PubMed

Thevenet D, Tardieu M, Zouhal H, Jacob C, Abderrahman BA, Prioux J (2007) Influence of exercise intensity on time spent at high percentage of maximal oxygen uptake during an intermittent session in young endurancetrained athletes. Eur J Appl Physiol 102(1):19–26. https://doi.org/10.1007/s00421-007-0540-6 CrossRefPubMed

Townsend J, Stout J, Morton AB, Jajtner AR, González AM, Wells AJ, Mangine., et al (2013) Excess post-exercise oxygen consumption (EPOC) following multiple effort sprint and moderate aerobic exercise. Kinesiology 45(1):16–21

Tremblay A, Arguin H, Panahi S (2016) Capsaicinoids: a spicy solution to the management of obesity? Int J Obes 40(8):1198–1204. https://doi.org/10.1038/ijo.2015.253 CrossRef

Whiting S, Derbyshire EJ, Tiwari B (2014) Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data. Appetite 73:183–188. https://doi.org/10.1016/j.appet.2013.11.005 CrossRefPubMed

Yashiro K, Tonson A, Pecchi É, Vilmen C, Le Fur Y, Bernard M et al (2015) Capsiate supplementation reduces oxidative cost of contraction in exercising mouse skeletal muscle in vivo. PLoS One 10(6):e0128016. https://doi.org/10.1371/journal.pone.0128016 CrossRefPubMedPubMedCentral

Zafeiridis A, Sarivasiliou H, Dipla K, Vrabas IS (2010) The effects of heavy continuous versus long and short intermittent aerobic exercise protocols on oxygen consumption, heart rate, and lactate responses in adolescents. Eur J Appl Physiol 110(1):17–26. https://doi.org/10.1007/s00421-010-1467-x CrossRefPubMed

Zagatto A, Redkva P, Loures J, Kalva Filho C, Franco V, Kaminagakura E et al (2011) Anaerobic contribution during maximal anaerobic running test: correlation with maximal accumulated oxygen deficit. Scand J Med Sci Sports 21(6):e222–e230. https://doi.org/10.1111/j.1600-0838.2010.01258.x CrossRefPubMed

Title: Capsaicin supplementation increases time to exhaustion in high-intensity intermittent exercise without modifying metabolic responses in physically active men
Authors: Marcelo Conrado de Freitas
François Billaut
Valéria Leme Gonçalves Panissa
Fabricio Eduardo Rossi
Caique Figueiredo
Erico Chagas Caperuto
Fabio Santos Lira
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Keyword: Capsaicin
Published in: European Journal of Applied Physiology / Issue 4/2019
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-019-04086-w

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Capsaicin supplementation increases time to exhaustion in high-intensity intermittent exercise without modifying metabolic responses in physically active men

Abstract

Purpose

Method

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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