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World Journal of Surgery

Published in:

01-05-2012

Cancer Stem Cell Marker Bmi-1 Expression is Associated with Basal-like Phenotype and Poor Survival in Breast Cancer

Authors: Yanyang Wang, Hong Zhe, Zhe Ding, Ping Gao, Ningmei Zhang, Guofu Li

Published in: World Journal of Surgery | Issue 5/2012

Abstract

Background

The purpose of present study was to examine the expression of cancer stem cell marker Bmi-1 in breast cancer tissue and to evaluate the clinical implication of Bmi-1 expression for these patients.

Methods

A total of 171 breast cancer patients who received surgical treatment in our hospital were enrolled in this study. Bmi-1 expression in breast cancer tissue was assayed by immunohistochemistry. Statistical analyses were applied to test the relationship between expression of Bmi-1 and clinicopathologic features and patient survival. The relationship between Bmi-1 and the basal-like phenotype of breast cancer also was analyzed in this study.

Results

Positive Bmi-1 expression was detected in 89 of 171 (52%) invasive breast cancers patients. The Bmi-1 status was significantly correlated to histological grade III (p = 0.001) and basal-like phenotype (p < 0.001). The 5 year overall survival of the patients with Bmi-1-positive and -negative cancers were 78 and 91.9%, respectively (p = 0.03). Histological grade (p = 0.046) and Bmi-1 status (p = 0.012) were detected as the independent prognostic factors in the Cox regression test.

Conclusions

Bmi-1 status is an independent prognostic factor, which also is associated with tumor histological grade and basal-like phenotype. The high proportions of positive Bmi-1 expression in basal-like breast cancer may be related to the high aggressiveness behavior of this subtype of breast cancer.

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Title: Cancer Stem Cell Marker Bmi-1 Expression is Associated with Basal-like Phenotype and Poor Survival in Breast Cancer
Authors: Yanyang Wang
Hong Zhe
Zhe Ding
Ping Gao
Ningmei Zhang
Guofu Li
Publication date: 01-05-2012
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 5/2012
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-012-1514-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cancer Stem Cell Marker Bmi-1 Expression is Associated with Basal-like Phenotype and Poor Survival in Breast Cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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