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BMC Cancer
Published in: BMC Cancer 1/2015

Open Access 01-12-2015 | Research article

Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai

Authors: Hui-Lin Xu, Hong Fang, Wang-Hong Xu, Guo-You Qin, Yu-Jie Yan, Bao-Dong Yao, Nai-Qing Zhao, Yi-Nan Liu, Fen Zhang, Wei-Xi Li, Na Wang, Jie Zhou, Jin-Ling Zhang, Li-Yun Zhao, Lun-Qiang Li, Yan-Ping Zhao

Published in: BMC Cancer | Issue 1/2015

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Abstract

Background

Type 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers. The aim of this study was to investigate the risk of common cancers in Chinese patients with T2DM.

Methods

A population-based retrospective cohort study including 36,379 T2DM patients was conducted in Minhang District of Shanghai, China, during 2004 to 2010. All T2DM patients were enrolled from the standardized management system based on local electronic information system. Newly-diagnosed cancer cases were identified by record-linkage with the Shanghai Cancer Registry. Standardized incidence ratios (SIR) and 95 % confidence interval (CI) were used to estimate the risk of cancers among T2DM patients.

Results

Overall crude incidence rate (CIR) of cancers was 955.21 per 105 person-years in men and 829.57 per 105 person-years in women. Increased risk of cancer was found in both gender, with an SIR being 1.28 (95 % CI = 1.17–1.38) in men and 1.44 (95 % CI =1.32–1.55) in women. Increased risk of colon (SIR = 1.97; 95 % CI = 1.49 to 2.46), rectum (1.72; 1.23 to 2.21), prostate (2.87; 2.19 to 3.56), and bladder cancers (1.98, 1.28 to 2.68) were observed in men and elevated risk of colon (1.67; 1.25 to 2.08), breast (1.66; 1.38 to 1.95), and corpus uteri cancers (2.87; 2.03 to 3.71) were observed in women.

Conclusions

Our results indicate that Chinese patients with T2DM may have an increased risk of some cancers, and the increase may vary by sub-sites of cancers.
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Metadata
Title
Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai
Authors
Hui-Lin Xu
Hong Fang
Wang-Hong Xu
Guo-You Qin
Yu-Jie Yan
Bao-Dong Yao
Nai-Qing Zhao
Yi-Nan Liu
Fen Zhang
Wei-Xi Li
Na Wang
Jie Zhou
Jin-Ling Zhang
Li-Yun Zhao
Lun-Qiang Li
Yan-Ping Zhao
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2015
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-015-1887-4

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