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Cancer Chemotherapy and Pharmacology

Issue 3/2012

Content (16 Articles)

Review Article

Antiangiogenic therapy in the management of brain tumors: a clinical overview

Saroj Kunnakkat, Maya Mathew, Ashwatha Narayana

Original Article

Increased expression and function of P-glycoprotein in peripheral blood CD56+ cells is associated with the chemoresistance of non-small-cell lung cancer

Li Han, Ya Feng Wang, Yan Zhang, Ning Wang, Xiao Juan Guo, Jing Ke Yang, Kui Peng Wang, Su Na Liu, Qing Xia Fan, Ke Li, Jin Hua Jiang, Qing Duan Wang

Open Access Original Article

Pharmacokinetics of sepantronium bromide (YM155), a small-molecule suppressor of survivin, in Japanese patients with advanced solid tumors: dose proportionality and influence of renal impairment

Yumiko Aoyama, Tetsuya Nishimura, Taiji Sawamoto, Taroh Satoh, Masataka Katashima, Kazuhiko Nakagawa

Original Article

Phase II clinical trial of induction chemotherapy with fixed dose rate gemcitabine and cisplatin followed by concurrent chemoradiotherapy with capecitabine for locally advanced pancreatic cancer

Jae-Sung Kim, Joo Han Lim, Jee Hyun Kim, Seock-Ah Im, Eui Kyu Chie, Jin-Hyeok Hwang, Tae-You Kim, Yung-Jue Bang, Sung Whan Ha, Yong Bum Yoon

Original Article

Comparison of dose intensity of vincristine, d-actinomycin, and cyclophosphamide chemotherapy for child and adult rhabdomyosarcoma: a retrospective analysis

Yuki Kojima, Kenji Hashimoto, Masashi Ando, Kan Yonemori, Harukaze Yamamoto, Makoto Kodaira, Mayu Yunokawa, Chikako Shimizu, Kenji Tamura, Ako Hosono, Atsushi Makimoto, Yasuhiro Fujiwara

Original Article

Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer

Yosuke Togashi, Katsuhiro Masago, Satohiro Masuda, Tomoyuki Mizuno, Masahide Fukudo, Yasuaki Ikemi, Yuichi Sakamori, Hiroki Nagai, Young Hak Kim, Toshiya Katsura, Michiaki Mishima

Open Access Original Article

Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tumors

Haruyasu Murakami, Toshihiko Doi, Nobuyuki Yamamoto, Junichiro Watanabe, Narikazu Boku, Nozomu Fuse, Takayuki Yoshino, Atsushi Ohtsu, Satoru Otani, Kazuhiro Shibayama, Takatoshi Takubo, Elwyn Loh

Original Article

Anti-proliferative effect of 23,24-dihydrocucurbitacin F on human prostate cancer cells through induction of actin aggregation and cofilin-actin rod formation

Shuai Ren, Dong-Yun Ouyang, Mark Saltis, Li-Hui Xu, Qing-Bing Zha, Ji-Ye Cai, Xian-Hui He

Original Article

Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody–drug conjugates

Diego A. Gianolio, Cecile Rouleau, William E. Bauta, Dennis Lovett, William R. Cantrell Jr., Antonio Recio III, Paul Wolstenholme-Hogg, Michelle Busch, Peng Pan, James E. Stefano, Hildegard M. Kramer, James Goebel, Roy D. Krumbholz, Stephanie Roth, Steven M. Schmid, Beverly A. Teicher

Open Access Original Article

Use of low-dose combined therapy with gemcitabine and paclitaxel for advanced urothelial cancer patients with resistance to cisplatin-containing therapy: a retrospective analysis

Yasuyoshi Miyata, Koichiro Nomata, Kojiro Ohba, Tomohiro Matsuo, Yuji Sagara, Hiroshi Kanetake, Hideki Sakai

Open Access Original Article

Phase I study of the Aurora B kinase inhibitor barasertib (AZD1152) to assess the pharmacokinetics, metabolism and excretion in patients with acute myeloid leukemia

Mike Dennis, Michelle Davies, Stuart Oliver, Roy D’Souza, Laura Pike, Paul Stockman

Clinical Trial Report

A phase I trial of oral administration of panobinostat in combination with paclitaxel and carboplatin in patients with solid tumors

Suzanne F. Jones, Jeffrey R. Infante, Dana S. Thompson, Adil Mohyuddin, Johanna C. Bendell, Denise A. Yardley, Howard A. Burris III

Short Communication

AZ64 inhibits TrkB and enhances the efficacy of chemotherapy and local radiation in neuroblastoma xenografts

Radhika Iyer, Carly R. Varela, Jane E. Minturn, Ruth Ho, Anisha M. Simpson, Jennifer E. Light, Audrey E. Evans, Huaqing Zhao, Kenneth Thress, Jeffrey L. Brown, Garrett M. Brodeur

Reply to the Letter

In response

Masashi Kanai, Shigemi Matsumoto, Yoshihiko Otsuka, Masafumi Fukuda, Atsushi Imaizumi

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine