Issue 2/2005
Content (13 Articles)
In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative
Melinda Hollingshead, Michael Alley, Angelika M. Burger, Suzanne Borgel, Christine Pacula-Cox, Heinz-Herbert Fiebig, Edward A. Sausville
Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models
Victoria Smith, Edward A. Sausville, Richard F. Camalier, Heinz-Herbert Fiebig, Angelika M. Burger
A phase I study of doxifluridine combined with weekly paclitaxel for metastatic gastric cancer
Toshikazu Moriwaki, Ichinosuke Hyodo, Tomohiro Nishina, Ken Hirao, Takao Tsuzuki, Satoshi Hidaka, Takeshi Kajiwara, Shinji Endo, Junichirou Nasu, Shoji Hirasaki, Toshikazu Masumoto, Akira Kurita
Preclinical pharmacokinetics and oral bioavailability of BMS-310705, a novel epothilone B analog
Amrita V. Kamath, Ming Chang, Francis Y. Lee, Yueping Zhang, Punit H. Marathe
Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours
Lyly H. Lê, Malcolm J. Moore, Lillian L. Siu, Amit M. Oza, Martha MacLean, Bryn Fisher, Ajai Chaudhary, Dinesh P. de. Alwis, Christopher Slapak, Lesley Seymour
Single nucleotide polymorphisms modify the transporter activity of ABCG2
Kuniaki Morisaki, Robert W. Robey, Csilla Özvegy-Laczka, Yasumasa Honjo, Orsolya Polgar, Kenneth Steadman, Balázs Sarkadi, Susan E. Bates
Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin
Chantal Barthomeuf, Jérôme Grassi, Michel Demeule, Chantal Fournier, Dominique Boivin, Richard Béliveau
Phase-I dose escalation and sequencing study of docetaxel and continuous infusion topotecan in patients with advanced malignancies
James A. Posey, Hui Wang, JoElle Hamilton, Alma Delgrosso, Ruiwen Zhang, Timothy Freda, William C. Zamboni
Human cells deficient in transcription-coupled repair show prolonged activation of the Jun N-terminal kinase and increased sensitivity following cisplatin treatment
J. Todd Bulmer, Natalie J. Zacal, Andrew J. Rainbow
A phase II trial of docetaxel and vinorelbine in patients with hormone-refractory prostate cancer
Susan Goodin, Kamakshi V. Rao, Michael Kane, Nisha Dave, Terry Capanna, Susan Doyle-Lindrud, Elizabeth Engle, Lixian Jin, Mary Todd, Robert S. DiPaola
Pharmacokinetic and pharmacodynamic comparison of fluoropyrimidine derivatives, capecitabine and 5′-deoxy-5-fluorouridine (5′-DFUR)
Hiromichi Ebi, Yasushi Sigeoka, Toshiaki Saeki, Kenji Kawada, Tadahiko Igarashi, Noriko Usubuchi, Ryuzo Ueda, Yasutsuna Sasaki, Hironobu Minami
HERG K+ channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin
Shu-zhen Chen, Min Jiang, Yong-su Zhen