Issue 1/2000
Content (14 Articles)
Maximum tolerated doses of methotrexate and 7-hydroxy-methotrexate in a model of acute toxicity in rats
Ole-Martin Fuskevåg, Christel Kristiansen, Sigurd Lindal, Jarle Aarbakke
Effects of the aromatase inhibitor anastrozole on serum oestrogens in Japanese and Caucasian women
Mitchell Dowsett, Kirsteen Donaldson, Minoru Tsuboi, James Wong, Roger Yates
Dose escalation and pharmacokinetic study of irinotecan in combination with paclitaxel in patients with advanced cancer
John R. Murren, Kathleen Peccerillo, Susan A. DiStasio, Xin Li, Janine J. Leffert, Giuseppe Pizzorno, Barbara A. Burtness, Anne McKeon, Yung chi Cheng
Feasibility and pharmacokinetics of intraperitoneal suramin in advanced malignancy
Anneke M. Westermann, Ria Dubbelman, Jan P. Baars, Wouter H. Moolenaar, Jos H. Beijnen, Sjoerd Rodenhuis
Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis
Merry L. Tetef, Kim A. Margolin, James H. Doroshow, Steven Akman, Lucille A. Leong, Robert J. Morgan Jr., James W. Raschko, Neil Slatkin, George Somlo, Jeffrey A. Longmate, Mary I. Carroll, Edward M. Newman
A novel synthetic DNA minor groove binder, MS-247: antitumor activity and cytotoxic mechanism
Y. Matsuba, H. Edatsugi, I. Mita, A. Matsunaga, O. Nakanishi
Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats
Kunihiro Yoshisue, Kazue Hironaga, Syuji Yamaguchi, Akira Yamamoto, Sekio Nagayama, Yasuro Kawaguchi
Primary treatment of low-grade non-Hodgkin's lymphoma using an all oral anthracycline-containing regimen, chlorambucil, idarubicin, dexamethasone (CID) – a phase II study
Penelope Taylor, Graham Jackson, Michael Galloway, Michael Soukop, Hazel Tinegate, Brian Angus, Stephen Proctor
A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility
F. M. Sirotnak, Laura Sepp-Lorenzino, Nancy E. Kohl, Neal Rosen, Howard I. Scher
Selenium compounds prevent the induction of drug resistance by cisplatin in human ovarian tumor xenografts in vivo
Paula B. Caffrey, Gerlad D. Frenkel
Pegylated liposome-encapsulated doxorubicin and cisplatin in the treatment of head and neck xenograft tumours
Kevin J. Harrington, Gail Rowlinson-Busza, Paul S. Uster, J. Simon Stewart
Pharmacokinetics of 2-chloro-2′-deoxyadenosine administered subcutaneously or by continuous intravenous infusion
Theodor Sonderegger, Daniel C. Betticher, Thomas Cerny, Bernhard H. Lauterburg
Evaluation of toremifene for reversal of multidrug resistance in renal cell cancer patients treated with vinblastine
Jeremy P. Braybrooke, Katherine A. Vallis, Susan Houlbrook, Helen Rockett, Juha Ellmén, Markku Anttila, Trivadi S. Ganesan, Adrian L. Harris, Denis C. Talbot