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Cancer Immunology, Immunotherapy
Published in: Cancer Immunology, Immunotherapy 7/2005

01-07-2005 | Review

Cancer and aging: symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo

Authors: Masanobu Kitagawa, Masanori Utsuyama, Morito Kurata, Kouhei Yamamoto, Yasuhito Yuasa, Yuichi Ishikawa, Tomio Arai, Katsuiku Hirokawa

Published in: Cancer Immunology, Immunotherapy | Issue 7/2005

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Abstract

Although many hypotheses have been proposed to explain the strong link between aging and cancer, the exact mechanisms responsible for the increased frequency of occurrence of cancer with advancing age have not been fully defined. Recent evidence indicates that malregulation of the apoptotic process may be involved in some aging process as well as in the development of cancer. Although it is still under debate how apoptosis is expressed during aging in vivo, this phenomenon is an important factor in unwinding the complicated mechanisms that link cancer and aging. In this review, we report on the discussion at the symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, regarding recent findings from aging and carcinogenesis studies using animal models, the characteristics of cancer in patients with Werner’s syndrome, the epigenetic changes in human cancers and aging, and the characteristics of human cancers in the elderly. It was concluded that apoptosis plays a role in the aging process and carcinogenesis in vivo, likely as an inherent protective mechanism against various kinds of damages to genes/chromosomes.
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Metadata
Title
Cancer and aging: symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo
Authors
Masanobu Kitagawa
Masanori Utsuyama
Morito Kurata
Kouhei Yamamoto
Yasuhito Yuasa
Yuichi Ishikawa
Tomio Arai
Katsuiku Hirokawa
Publication date
01-07-2005
Publisher
Springer-Verlag
Published in
Cancer Immunology, Immunotherapy / Issue 7/2005
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-004-0622-9

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