Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Breast Cancer Research
Published in: Breast Cancer Research 1/2018

Open Access 01-12-2018 | Editorial

Can novel technologies improve breast conserving surgery?

Author: Brian W. Pogue

Published in: Breast Cancer Research | Issue 1/2018

Login to get access

Excerpt

The practice of breast conserving surgery has been transformative for management of women’s breast cancer [1], and yet the current practice remains in a situation where approximately one-third of all patients have incomplete surgical resection. This is measured by the finding of clear margins on the surgical specimen, as measured by pathology sampling. This is a very active area of professional debate and research study [2], and the solutions are not as obvious as one might guess. Still, reviews of the status of the field suggest that technical solutions should be available to help mitigate this issue [3], and the tools for molecular phenotyping of tissues need to be deployed if they can provide rapid, specific diagnoses. …
Literature
1.
Morrow M, Van Zee KJ, Solin LJ, Houssami N, Chavez-MacGregor M, Harris JR, Horton J, Hwang S, Johnson PL, Marinovich ML, Schnitt SJ, Wapnir I, Moran MS. Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in ductal carcinoma in situ. J Clin Oncol. 2016;34(33):4040–6.CrossRefPubMedPubMedCentral
2.
Brouwer de Koning SG, Vrancken Peeters M, Jozwiak K, Bhairosing PA, Ruers TJM. Tumor resection margin definitions in breast-conserving surgery: systematic review and meta-analysis of the current literature. Clin Breast Cancer. 2018.
3.
Gray RJ, Pockaj BA, Garvey E, Blair S. Intraoperative margin Management in Breast-Conserving Surgery: a systematic review of the literature. Ann Surg Oncol. 2018;25(1):18–27.CrossRefPubMed
4.
Shipp DW, Rakha EA, Koloydenko AA, Macmillan RD, Ellis IO, Notingher I. Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery. Breast Cancer Res. 2018;20(1):69.CrossRefPubMedPubMedCentral
5.
Manoharan R, Shafer K, Perelman L, Wu J, Chen K, Deinum G, Fitzmaurice M, Myles J, Crowe J, Dasari RR, Feld MS. Raman spectroscopy and fluorescence photon migration for breast cancer diagnosis and imaging. Photochem Photobiol. 1998;67(1):15–22.CrossRefPubMed
6.
Motz JT, Gandhi SJ, Scepanovic OR, Haka AS, Kramer JR, Dasari RR, Feld MS. Real-time Raman system for in vivo disease diagnosis. J Biomed Opt. 2005;10(3):031113.CrossRefPubMed
7.
Jermyn M, Desroches J, Aubertin K, St-Arnaud K, Madore WJ, De Montigny E, Guiot MC, Trudel D, Wilson BC, Petrecca K, Leblond F. A review of Raman spectroscopy advances with an emphasis on clinical translation challenges in oncology. Phys Med Biol. 2016;61(23):R370–400.CrossRefPubMed
8.
Wilson BC. Detection and treatment of dysplasia in Barrett's esophagus: a pivotal challenge in translating biophotonics from bench to bedside. J Biomed Opt. 2007;12(5):051401.CrossRefPubMed
9.
Jermyn M, Desroches J, Mercier J, Tremblay MA, St-Arnaud K, Guiot MC, Petrecca K, Leblond F. Neural networks improve brain cancer detection with Raman spectroscopy in the presence of operating room light artifacts. J Biomed Opt. 2016;21(9):94002.CrossRefPubMed
10.
Wilson BC, Jermyn M, Leblond F. Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging. J Biomed Opt. 2018;23(3):1–13.CrossRef
Metadata
Title
Can novel technologies improve breast conserving surgery?
Author
Brian W. Pogue
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2018
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/s13058-018-1016-9

Other articles of this Issue 1/2018

Breast Cancer Research 1/2018 Go to the issue

Research article

CYP2D6 phenotype, tamoxifen, and risk of contralateral breast cancer in the WECARE Study

Research article

Long-term exposure to insulin and volumetric mammographic density: observational and genetic associations in the Karma study

Research article

Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers

Research article

HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women

Research article

Inherited factors contribute to an inverse association between preeclampsia and breast cancer

Research article

Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits