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01-10-2013 | Letter to the Editor

CAM 5.2 shows specific reactivity for cytokeratin 8, but less strict reactivity for cytokeratin 7 and no reactivity for cytokeratin 18: in response to “Fujikawa T, Tanaka A, Abe T et al. ‘Undifferentiated carcinoma of the common bile duct with intraductal tumor thrombi: report of a case’. Surg Today 2011;41(4):579–84.”

Authors: Chiew-Loon Koo, Wan-Ru Chao, Chi-Kuan Chen, Chih-Ping Han

Published in: Surgery Today | Issue 10/2013

Excerpt

We read with great interest the case report contributed by Dr. T. Fujikawa et al. [1] titled “Undifferentiated carcinoma of the common bile duct with intraductal tumor thrombi”. The authors presented an interesting case with a comprehensive review; however, this article conveys an incorrect message in the second paragraph of the “Histopathologic Findings” section, which may misguide your readers. The authors seem to have overlooked the manufacturer’s names of all the antibodies used and erroneously annotated CAM 5.2 as cytokeratins 8/18 (within parentheses), which suggests that CAM 5.2 is identical to CK8/18. …

Fujikawa T, Tanaka A, Abe T, Yoshimoto H, Tokumitsu Y, Tada S, et al. Undifferentiated carcinoma of the common bile duct with intraductal tumor thrombi: report of a case. Surg Today. 2011;41(4):579–84.PubMedCrossRef

BD Biosciences. Anti-cytokeratin (CAM 5.2) reagent for in vitro diagnostic use. 50 tests per vial–catalog no. 349205. Data sheet http://www.bdbiosciences.com/external_files/is/doc/tds/Datasheets_RUO/live/web_enabled/23-1336-09-347653-347204-349205-DS-ruo.pdf. Accessed 11 Apr 2013 in Taiwan.

BD Biosciences. Anti-cytokeratin (CAM 5.2) reagent. http://www.bdbiosciences.com/ptProduct.jsp?prodId=22700&key=+Anti-cytokeratin+%28CAM+5.2%29&param=search&mterms=true&from=dTable, TDS1. Accessed 11 Apr 2013 in Taiwan.

Leica Biosystems, Novocastra™ Lyophilized Mouse Monoclonal Antibody Cytokeratin (8/18) Product Code: NCL-5D3. http://www.leicabiosystems.com/fileadmin/img_uploads/novocastra_reagents/Novocastra_datasheets/5d3-ce.pdf. Accessed 11 Apr 2013 in Taiwan.

Leica Biosystems. Novocastra™ Ready-to-Use Mouse monoclonal Antibody Cytokeratin (8/18) Product Code: RTU-5D3. http://www.leicabiosystems.com/fileadmin/img_uploads/novocastra_reagents/Novocastra_datasheets/5d3-r-7-ce.pdf. Accessed 11 Apr 2013 in Taiwan.

Makin CA, Bobrow LG, Bodmer WF. Monoclonal antibody to cytokeratin for use in routine histopathology. J Clin Pathol. 1984;37:975–83.PubMedCrossRef

Leica Biosystems. Bond™ Ready-to-Use Primary Antibody Cytokeratin7 (RN7). http://www.leicabiosystems.com/fileadmin/img_uploads/novocastra_reagents/Novocastra_datasheets/pa0942.pdf. Accessed 11 Apr 2013 in Taiwan.

Title: CAM 5.2 shows specific reactivity for cytokeratin 8, but less strict reactivity for cytokeratin 7 and no reactivity for cytokeratin 18: in response to “Fujikawa T, Tanaka A, Abe T et al. ‘Undifferentiated carcinoma of the common bile duct with intraductal tumor thrombi: report of a case’. Surg Today 2011;41(4):579–84.”
Authors: Chiew-Loon Koo
Wan-Ru Chao
Chi-Kuan Chen
Chih-Ping Han
Publication date: 01-10-2013
Publisher: Springer Japan
Published in: Surgery Today / Issue 10/2013
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-013-0600-y

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