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BMC Anesthesiology
Published in: BMC Anesthesiology 1/2023

Open Access 01-12-2023 | CABG | Research

The effect of intravenous lidocaine on postoperative cognitive dysfunction: a systematic review and meta-analysis

Authors: Chuan Geng, Baoji Hu, Jihong Jiang, Yunhe Zhang, Weiqing Tang, Mengzhi Pan, Leilei Sun, Peifen Chen, Hengyue Wang

Published in: BMC Anesthesiology | Issue 1/2023

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Abstract

Background

Postoperative cognitive dysfunction (POCD) has been reported as a significant complication in elderly patients. Various methods have been proposed for reducing the incidence and severity of POCD. Intravenous lidocaine administration has been reported in the literature to reduce POCD, but the effect of lidocaine remains controversial.

Methods

We screened Medline, Embase, Cochrane Library, and China National Knowledge Infrastructure (up to April 2022) databases following a search strategy for intravenous lidocaine on POCD. We also screened related bibliographies on lidocaine for POCD. Ten articles comprising 1517 patients were selected and analyzed. We divided the postoperative follow-up period as follows: short term (<30 days), medium term (30–90 days), and long term (>90 days).

Outcomes

We found that lidocaine could attenuate the overall incidence of POCD, especially in the short term. There were no differences between lidocaine and placebo on the overall severity of POCD.

Conclusion

Lidocaine administered intravenously could attenuate the overall incidence of POCD and its severity in the short term.
Appendix
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Metadata
Title
The effect of intravenous lidocaine on postoperative cognitive dysfunction: a systematic review and meta-analysis
Authors
Chuan Geng
Baoji Hu
Jihong Jiang
Yunhe Zhang
Weiqing Tang
Mengzhi Pan
Leilei Sun
Peifen Chen
Hengyue Wang
Publication date
01-12-2023
Publisher
BioMed Central
Keywords
CABG
CABG
Published in
BMC Anesthesiology / Issue 1/2023
Electronic ISSN: 1471-2253
DOI
https://doi.org/10.1186/s12871-023-02202-0

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