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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 6/2016

01-06-2016 | Reproductive Physiology and Disease

Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway

Authors: Tian Xia, Yu Fu, Shuang Li, Ruihong Ma, Zhimei Zhao, Baojuan Wang, Chune Chao

Published in: Journal of Assisted Reproduction and Genetics | Issue 6/2016

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Abstract

Purpose

The purpose of this study was to explore the molecular pathway of BSTCR (Bu Shen Tiao Chong recipe) in retrieving diminished ovary reserve (DOR).

Methods

The DOR model was established through injecting cyclophosphamide and the effect of BSTCR was examined under this background.

Results

BSTCR was shown to restore depleted brain-derived neurotrophic factor (BDNF), CDC2, cyclin B, GSH1, and P38 levels as well as impaired oocyte maturation and the higher apoptosis induced in DOR. BSTCR also enhances the response of oocytes to in vitro fertilization, with higher implantation rate, birth rate, and placenta weight.

Conclusion

BSTCR might exert its beneficial role in oocyte maturation and restore DOR through regulating the BDNF pathway. And this pathway itself is probably through the consequence on several serum hormones such as FSH, E2, Inhibin B, etc.
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Metadata
Title
Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway
Authors
Tian Xia
Yu Fu
Shuang Li
Ruihong Ma
Zhimei Zhao
Baojuan Wang
Chune Chao
Publication date
01-06-2016
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 6/2016
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-016-0697-1

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