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01-12-2016 | Case Report

Brown tumor of secondary hyperparathyroidism: surgical approach and clinical outcome

Authors: Isaac Vieira Queiroz, Samara Pereira Queiroz, Rui Medeiros Jr., Rodolfo Bonfim Ribeiro, Iêda Margarida Crusoé-Rebello, Jair Carneiro Leão

Published in: Oral and Maxillofacial Surgery | Issue 4/2016

Abstract

Background

Secondary hyperparathyroidism is a frequent complication of chronic renal failure. The brown tumor is an unusual presentation of fibrous osteitis that represents a serious complication of renal osteodystrophy, affecting predominantly the hands, feet, skull, and facial bones.

Case report

The aim of this paper is to describe the case of a 53-year-old female patient, with renal failure who has been on dialysis for 6 years and developed severe secondary hyperparathyroidism and brown tumor of the maxilla and mandible, confirmed by incisional biopsy. Parathyroidectomy was indicated as a result of rapid growth of the tumor and the maintenance of laboratory findings. Despite the normalization of serum parathyroid hormone and alkaline phosphatase, tumor regression was slow and patient’s important functional and esthetic deficits persisted. Excision of the mandible tumor was conservative. Osteoplasty was recommended because during a 5-year follow-up there was regression of the lesion, decreased pain, bleeding, and tooth mobility.

Nabi Z, Algailani M, Abdelsalam M, Asaad L, Albaqumi M (2010) Regression of brown tumor of the maxilla in a patient with secondary hyperparathyroidism after a parathyroidectomy. Hemodial Int 14:247–249CrossRefPubMed

Mateo L, Massuet A, Solà M, Pérez Andrés R, Musulen E, Sánchez Torres MC (2011) Brown tumor of the cervical spine: a case report and review of the literature. Clin Rheumatol 30:419–424CrossRefPubMed

Selvi F, Cakarer S, Tanakol R, Guler SD, Keskin C (2009) Brown tumour of the maxilla and mandible: a rare complication of tertiary hyperparathyroidism. Dentomaxillofac Radiol 38:53–58CrossRefPubMed

Nunes TB, Bologna SB, Witzel AL, Nico MMS, Lourenço SV (2016) A rare case of concomitant maxilla and mandible brown tumours, papillary thyroid carcinoma, parathyroid adenoma, and osteitis fibrosa cystica. Case Rep Dent. doi:10.1155/2016/5320298 PubMedPubMedCentral

Verma P, Verma KG, Verma D, Patwardhan N (2014) Craniofacial brown tumor as a result of secondary hyperparathyroidism in chronic renal disease patient: a rare entity. J Oral Maxillofac Pathol 18(2):267–270. doi:10.4103/0973-029X.140779 CrossRefPubMedPubMedCentral

Fatma LB, Barbouch S, Fethi BH, Imen BA, Karima K, Imed H, Fethi el Y, Fatma BM, Rim G, Taieb BA, Maiz HB, Adel K (2010) Brown tumor in patients with renal failure and secondary hyperparathyroidism: report of 12 cases. Saudi J Kidney Dis Transpl 21(4):772–777PubMed

Leal CTS, Lacativa PGS, Gomes EMS, Nunes RC, Costa FLFDS, Gandelmann IHA, et al. (2006) Surgical approach and clinical outcome of a deforming brown tumour at the maxilla in a patient with secondary hyperparathyroidism due to chronic renal failure. Arq Bras Endocrinol Metab 50(5):963–967CrossRef

Proimos E, Chimona TS, Tamiolakis D, Tzanakakis MG, Papadakis CE (2009) Brown tumor of the maxillary sinus in a patient with primary hyperparathyroidism: a case report. J Med Case Rep 3:7495. doi:10.4076/1752-1947-3-7495

Qaisi M, Loeb M, Montague L, Caloss R (2015) Mandibular brown tumor of secondary hyperparathyroidism requiring extensive resection: a forgotten entity in the developed world? Case Reports in Medicine. doi:10.1155/2015/567543 PubMedPubMedCentral

10.

Di Daniele N, Condò S, Ferrannini M, Bertoli M, Rovella V, Di Renzo L, De Lorenzo A (2009) Brown tumor in a patient with secondary hyperparathyroidism resistant to medical therapy: case report on successful treatment after subtotal parathyroidectomy. Int J Endocrinol 1:1–3CrossRef

11.

Jafari-Pozve N, Ataie-Khorasgani M, Jafari-Pozve S, Ataie-Khorasgani M (2014) Maxillofacial brown tumors in secondary hyperparathyroidism: a case report and literature review. J Res Med Sci 19(11):1099–1102PubMedPubMedCentral

12.

Takeshita T, Tanaka H, Harasawa A, Kaminaga T, Imamura T, Furui S (2004) Brown tumor of the sphenoid sinus in a patient with secondary hyperparathyroidism: CT and MR imaging findings. Radiat Med 22(4):265–268PubMed

13.

Tarrass F, Ayad A, Benjelloun M, Anabi A, Ramdani B, Benghanem MG, Zaid D (2006) Cauda equina compression revealing brown tumor of the spine in a long-term hemodialysis patient. Joint Bone Spine 73:748–750CrossRefPubMed

14.

Desigan S, Syed R, Conway GS, Kurzawinski TR, Bomanji JB (2007) Giant cervical parathyroid adenoma mimicking a sternocleidomastoid mass and presenting as a brown tumor of the mandible. Clin Nucl Med 32(4):306–308CrossRefPubMed

Title: Brown tumor of secondary hyperparathyroidism: surgical approach and clinical outcome
Authors: Isaac Vieira Queiroz
Samara Pereira Queiroz
Rui Medeiros Jr.
Rodolfo Bonfim Ribeiro
Iêda Margarida Crusoé-Rebello
Jair Carneiro Leão
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Oral and Maxillofacial Surgery / Issue 4/2016
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-016-0575-0

At a glance: The STEP trials

Springer Medicine

Brown tumor of secondary hyperparathyroidism: surgical approach and clinical outcome

Abstract

Background

Case report

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case report

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