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BMC Pediatrics

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Open Access 01-12-2021 | Bronchiectasis | Research

Prognosis and treatment of 46 Chinese pediatric cystic fibrosis patients

Authors: Qionghua Chen, Yuelin Shen, Hui Xu, Xiaolei Tang, Haiming Yang, Shunying Zhao

Published in: BMC Pediatrics | Issue 1/2021

Abstract

Background

Since public awareness of cystic fibrosis (CF) has increased, more children have been diagnosed with CF in China. This study aimed to investigate medical and other challenges faced by pediatric CF patients in China.

Method

Treatments and treatment outcomes were retrospectively analyzed for 46 pediatric CF patients diagnosed from August 2009 to June 2019. Pre- and post-treatment results were compared using independent samples t-test.

Results

Of 46 pediatric CF study patients, four died and five were lost to follow-up. Thirty-seven patients were monitored for 0.03 to 9.21 years; patients exhibited fewer attacks of respiratory tract infections after diagnosis (4.49 ± 2.13 episodes/year before diagnosis vs 1.97 ± 1.87 times/year after 1-year treatment, p < 0.05), significantly reduced sputum production and experienced 1.62 ± 1.71 exacerbations/year. Patient mean body mass index was 16.87 ± 3.53 and pancreatic malfunction persisted in 15 patients. For 17 children, no significant differences in lung function were found at follow-up as compared to lung function at diagnosis (FEV₁: 82.45% ± 16.56% vs 75.26% ± 22.34%, FVC: 87.18% ± 13.64% vs 86.99% ± 19.95%, FEF_75%: 46.51% ± 28.78% vs 36.63% ± 24.30%, P = 0.27, 0.97, 0.20, respectively). Pseudomonas aeruginosa (17/27) and bronchiectasis (22/22) were found during follow-up evaluation. Twenty-four patients (64.8%) maintained good adherence to therapies. Overall, azithromycin and tobramycin treatments were administered for 0.5–62 months and 0.5–48 months, respectively, and triggered no obvious adverse reactions.

Conclusion

No obvious declines in clinical presentation or lung function were found in Chinese pediatric CF patients after receiving standard therapeutic and active treatments, although malnutrition and low compliance were persistent challenges.

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Title: Prognosis and treatment of 46 Chinese pediatric cystic fibrosis patients
Authors: Qionghua Chen
Yuelin Shen
Hui Xu
Xiaolei Tang
Haiming Yang
Shunying Zhao
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Bronchiectasis
Cystic Fibrosis
Tobramycin
Azithromycin
Cystic Fibrosis
Pseudomonas Aeruginosa
Published in: BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-021-02789-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognosis and treatment of 46 Chinese pediatric cystic fibrosis patients

Abstract

Background

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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