Published in:
Open Access
28-03-2024 | Breast Surgery | ASO Author Reflections
ASO Author Reflections: The Impact of DCIS on Positive Margin Rates
Authors:
Hemali Chauhan, MBBS, BSc (Hons), MRCS, Hutan Ashrafian, PhD, MRCS, MBA, Zoltan Takats, PhD, Daniel Richard Leff, MBBS, FRCS, PhD, MS (Hons)
Published in:
Annals of Surgical Oncology
|
Issue 6/2024
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Excerpt
Anecdotally, surgeons regularly attribute a greater risk of margin positivity with ductal carcinoma in situ (DCIS) compared with its invasive counterpart. Although confirmed in the literature, previous reports grossly underestimate the risk of margin positivity with invasive breast cancer (IBC) containing a DCIS component (IBC + DCIS).
1 We suspect that this is the result of the limitations of previous work, which focused on patient-level rather than margin-level analysis since studies evaluated diagnostic core biopsy data (DCIS present vs. DCIS absent) or patient-level data held in National databases (DCIS component in the primary tumour vs. no DCIS component in the primary tumour) rather than a detailed margin-level analysis (i.e., DCIS present at the margin vs no DCIS present at the margin) to characterise and validate the histopathological relationships. This study delineates the relative risk of IBC + DCIS compared with pure IBC (without a DCIS component) on margin positivity through detailed margin level interrogation. …
