Breast sarcoma showing myofibroblastic differentiation

Excerpt

Sir, Myofibroblasts were originally described as a part of granulation tissue and healing wounds 30 years ago and were extensively studied in the past 20 years. However, the precise definition of myofibroblast as a distinctive cell type is still controversial as well as the concept of myofibroblast being neoplastic. Irrespective of that, it cannot be denied that tumors composed mainly of myofibroblasts do exist. Most of them are benign, i.e., myofibroblastomas [2, 4, 9], some with borderline biological course, i.e., inflammatory myofibroblastic tumor [1], and, rarely, they pursue a malignant biological behavior [2]. Among them, a distinctive form of low-grade myofibroblastic sarcoma was recognized [5, 7, 8], while high-grade lesions have not yet been well characterized. Here, we present the case of unusual high-grade breast sarcoma, which is showing myofibroblastic differentiation. …