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Magnetic Resonance Materials in Physics, Biology and Medicine
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 3/2021

01-06-2021 | Breast MRI | Research Article

A radiomics pipeline dedicated to Breast MRI: validation on a multi-scanner phantom study

Authors: Marie-Judith Saint Martin, Fanny Orlhac, Pia Akl, Fahad Khalid, Christophe Nioche, Irène Buvat, Caroline Malhaire, Frédérique Frouin

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2021

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Abstract

Objective

Quantitative analysis in MRI is challenging due to variabilities in intensity distributions across patients, acquisitions and scanners and suffers from bias field inhomogeneity. Radiomic studies are impacted by these effects that affect radiomic feature values. This paper describes a dedicated pipeline to increase reproducibility in breast MRI radiomic studies.

Materials and methods

T1, T2, and T1-DCE MR images of two breast phantoms were acquired using two scanners and three dual breast coils. Images were retrospectively corrected for bias field inhomogeneity and further normalised using Z score or histogram matching. Extracted radiomic features were harmonised between coils by the ComBat method. The whole pipeline was assessed qualitatively and quantitatively using statistical comparisons on two series of radiomic feature values computed in the gel mimicking the normal breast tissue or in dense lesions.

Results

Intra and inter-acquisition variabilities were strongly reduced by the standardisation pipeline. Harmonisation by ComBat lowered the percentage of radiomic features significantly different between the three coils from 87% after bias field correction and MR normalisation to 3% in the gel, while preserving or improving performance of lesion classification in the phantoms.

Discussion

A dedicated standardisation pipeline was developed to reduce variabilities in breast MRI, which paves the way for robust multi-scanner radiomic studies but needs to be assessed on patient data.
Appendix
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Metadata
Title
A radiomics pipeline dedicated to Breast MRI: validation on a multi-scanner phantom study
Authors
Marie-Judith Saint Martin
Fanny Orlhac
Pia Akl
Fahad Khalid
Christophe Nioche
Irène Buvat
Caroline Malhaire
Frédérique Frouin
Publication date
01-06-2021
Publisher
Springer International Publishing
Keyword
Breast MRI
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2021
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-020-00892-y

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