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01-07-2014 | Breast Oncology

Breast-Conserving Therapy: A Viable Option for Young Women with Early Breast Cancer—Evidence from a Prospective Study

Authors: Zeming Xie, MD, PhD, Xi Wang, MD, PhD, Huanxin Lin, MD, Weidong Wei, MD, PhD, Peng Liu, MD, Xiangsheng Xiao, MD, Xiaoming Xie, MD, PhD, Xunhang Guan, MD, Mingtian Yang, MD, Jun Tang, MD, PhD

Published in: Annals of Surgical Oncology | Issue 7/2014

Abstract

Background

This study evaluated the security of breast-conserving treatment (BCT) in young patients and the effect of regional radiation therapy on young patients with 1–3 positive nodes (N+) treated with BCT.

Methods

In this prospective concurrent controlled study, 164 patients were defined as the BCT group, and regional radiation therapy was delivered to patients with 1–3 N+. Modified radical mastectomies (MRMs) were performed on 224 patients without regional radiation therapy.

Results

The 9-year local recurrence (LR) rate of the BCT was 7 %, compared with 3 % in the MRM group (p = 0.055). The 9-year regional recurrence (RR) rate was 6 % for the BCT group and 12 % for the MRM group (p = 0.048). The distant metastasis (DM)-free and breast cancer-specific survival rates were similar between the two groups. RR was an independent prognostic factor for DM [hazard ratio 3.27; 95 % confidence interval (CI) 1.726–6.208] and breast cancer-specific survival (hazard ratio 5.814; 95 % CI 2.690–12.568), whereas LR was not an independent prognostic factor for DM or breast cancer-specific survival.

Conclusions

Young patients treated with BCT have a higher LR rate than that of MRM. However, LR has no detrimental effect on DM-free and breast cancer-specific survival rates, whereas RR is a strong risk factor of DM and death. Regional radiation therapy for young patients with 1–3 N+ may reduce RR and improve survival rates.

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Title: Breast-Conserving Therapy: A Viable Option for Young Women with Early Breast Cancer—Evidence from a Prospective Study
Authors: Zeming Xie, MD, PhD
Xi Wang, MD, PhD
Huanxin Lin, MD
Weidong Wei, MD, PhD
Peng Liu, MD
Xiangsheng Xiao, MD
Xiaoming Xie, MD, PhD
Xunhang Guan, MD
Mingtian Yang, MD
Jun Tang, MD, PhD
Publication date: 01-07-2014
Publisher: Springer US
Published in: Annals of Surgical Oncology / Issue 7/2014
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-014-3620-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Breast-Conserving Therapy: A Viable Option for Young Women with Early Breast Cancer—Evidence from a Prospective Study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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