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Cancer Cell International
Published in: Cancer Cell International 1/2019

Open Access 01-12-2019 | Breast Cancer | Primary research

High expression of Linc00959 predicts poor prognosis in breast cancer

Authors: Weiru Chi, Sheng Huang, Bingqiu Xiu, Qi Zhang, Zhiming Shao, Jiong Wu, Yayun Chi

Published in: Cancer Cell International | Issue 1/2019

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Abstract

Background

Accumulating studies have focused on the oncogenic roles of the newly identified lncRNAs in human cancers. The aim of this study was to examine the expression pattern of Linc00959 in BC and to evaluate its biological role and clinical significance in prediction of prognosis.

Methods

Expression of Linc00959 was detected in 290 BC tissues by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). We analyzed the relationship between Linc00959 expression and clinic pathological features of BC patients. The correlation was calculated by SPSS software.

Results

Our results revealed that Linc00959 expression was correlated with ER status (p = 0.005), PR status (p = 0.036), Ki67 (p = 0.025) and HER2 status (p = 0.009). The Kaplan–Meier survival curves indicated that the overall survival (OS) (p = 0.022) and relapse-free survival (RFS) (p = 0.002) were significantly poor in high Linc00959 expression BC patients (p = 0.023). Furthermore, the survival analysis by Cox regression showed that Linc00959 served as an independent prognostic marker in breast cancer (p = 0.004).

Conclusion

Our studies indicate that Linc00959 is significantly associated with poor prognosis and may represent a new marker of prognosis in breast cancer.
Appendix
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Metadata
Title
High expression of Linc00959 predicts poor prognosis in breast cancer
Authors
Weiru Chi
Sheng Huang
Bingqiu Xiu
Qi Zhang
Zhiming Shao
Jiong Wu
Yayun Chi
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2019
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-019-0748-7

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