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01-07-2021 | Breast Cancer | Original Article

Effects of synbiotic supplementation on serum adiponectin and inflammation status of overweight and obese breast cancer survivors: a randomized, triple-blind, placebo-controlled trial

Authors: Mahsa Raji Lahiji, Mitra Zarrati, Safa Najafi, Bahareh Yazdani, Elhameh Cheshmazar, Elham Razmpoosh, Leila Janani, Mahtab Raji Lahiji, Farzad Shidfar

Published in: Supportive Care in Cancer | Issue 7/2021

Abstract

Purpose

Adipokines and inflammatory factors can affect breast cancer (BC) prognosis and recurrence among breast cancer survivors (BCSs). This study was to evaluate the effects of synbiotic supplementation along with a low-calorie diet on some recurrence-related factors such as adiponectin, tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) among obese and overweight BCSs.

Methods

We performed a randomized, triple-blind, placebo-controlled clinical trial among 76 overweight or obese postmenopausal women with a history of hormone-receptor-positive BC. Participants were randomly divided into 2 groups to intake either 10⁹ CFU/day synbiotic supplement or placebo (n = 38 each group) for 8 weeks. All participants were given a low-calorie diet program. The primary outcome was serum concentration of adiponectin which was measured at baseline and after 8 weeks.

Results

Compared with the placebo, synbiotic intake significantly increased adiponectin (+ 13.58 (10.08, 18.17) vs. − 0.42 (− 2.90, 1.98) μg/ml; P < 0.001). In addition, synbiotic supplementation resulted in significant reduction in TNF-α levels (− 17.09 (− 32.05, − 13.60) vs. 0.20 (− 3.97, 2.00) ng/L; P < 0.001) and hs-CRP levels (− 1.14 (− 1.90, − 0.88 vs. − 0.06 (− 0.38, 0.15) mg/L; P < 0.001) compared with the placebo.

Conclusions

In conclusion, 8-week synbiotic consumption by overweight and obese postmenopausal BCSs had beneficial effects on adiponectin, TNF-α, and hs-CRP.

Trial registration

IRCT, IRCT20091114002709N49. Registered 18 May 2018, http://www.irct.ir: IRCT20091114002709N49

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Title: Effects of synbiotic supplementation on serum adiponectin and inflammation status of overweight and obese breast cancer survivors: a randomized, triple-blind, placebo-controlled trial
Authors: Mahsa Raji Lahiji
Mitra Zarrati
Safa Najafi
Bahareh Yazdani
Elhameh Cheshmazar
Elham Razmpoosh
Leila Janani
Mahtab Raji Lahiji
Farzad Shidfar
Publication date: 01-07-2021
Publisher: Springer Berlin Heidelberg
Keywords: Breast Cancer
Breast Cancer
Overweight
Published in: Supportive Care in Cancer / Issue 7/2021
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-020-05926-8

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