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BMC Medical Genetics

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Open Access 01-12-2019 | Breast Cancer | Research article

Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population

Authors: Laith N. AL-Eitan, Doaa M. Rababa’h, Mansour A. Alghamdi, Rame H. Khasawneh

Published in: BMC Medical Genetics | Issue 1/2019

Abstract

Background

Single nucleotide polymorphisms (SNPs) in several CYP genes have been associated with altered breast cancer (BC) risk in different populations. Despite this, there is a dearth of information on the roles of these SNPs in Jordanian BC patients. Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population. In addition, this work investigates the association between selected BC prognostic factors and variants of the aforementioned CYP candidate genes.

Methods

Blood samples were withdrawn from 221 BC patients and 218 healthy volunteers recruited from the Jordanian population. Genomic DNA was withdrawn and, after quantification and quality control, was genotyped using the Sequenom MassARRAY® system (iPLEX GOLD). Statistical analysis was then carried out to assess allelic and genotypic frequencies as well as genetic association between cases and controls.

Results

The CYP19A1 SNP rs7176005 (p < 0.0045) and the CYP1A2 SNP rs762551 (p = 0.004) were significantly associated with BC risk. However, no such association was found for the screened SNPs of the CYP2C9, CYP1B1, CYP2C19 and CYP3A4 genes. Regarding the prognostic factors of BC, several of the screened SNPs were associated with different pathological and clinical features.

Conclusions

Certain CYP genes, particularly CYP19A1 and CYP1A2, were associated with BC risk and development in the Jordanian population.

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Title: Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population
Authors: Laith N. AL-Eitan
Doaa M. Rababa’h
Mansour A. Alghamdi
Rame H. Khasawneh
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Breast Cancer
Breast Cancer
Published in: BMC Medical Genetics / Issue 1/2019
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/s12881-019-0884-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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