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Breast Cancer Research
Published in: Breast Cancer Research 2/2006

01-11-2006 | Oral Presentation

BRCA1 transcriptionally regulates genes associated with the basal breast cancer phenotype

Authors: JE Quinn, CR James, JJ Gorskii, PB Mullan, DP Harkin

Published in: Breast Cancer Research | Special Issue 2/2006

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Excerpt

Ten to twenty per cent of breast tumours exhibit a basal-like genetic profile and these tumours carry a poor prognosis. Breast tumours which contain germline mutations for BRCA1 commonly exhibit a molecular profile similar to basal breast tumours. BRCA1 is a tumour suppressor gene which is mutated in up to 5–10% of breast cancer cases and is involved in multiple cellular processes including DNA damage control, cell cycle checkpoint control, apoptosis, ubiquitination and transcriptional regulation. …
Metadata
Title
BRCA1 transcriptionally regulates genes associated with the basal breast cancer phenotype
Authors
JE Quinn
CR James
JJ Gorskii
PB Mullan
DP Harkin
Publication date
01-11-2006
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2006
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1547

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