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Published in: Acta Neuropathologica 4/2019

01-04-2019 | Brain Tumor | Review

Translational control in brain pathologies: biological significance and therapeutic opportunities

Authors: Alberto Delaidelli, Asad Jan, Jochen Herms, Poul H. Sorensen

Published in: Acta Neuropathologica | Issue 4/2019

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Abstract

Messenger RNA (mRNA) translation is the terminal step in protein synthesis, providing a crucial regulatory checkpoint for this process. Translational control allows specific cell types to respond to rapid changes in the microenvironment or to serve specific functions. For example, neurons use mRNA transport to achieve local protein synthesis at significant distances from the nucleus, the site of RNA transcription. Altered expression or functions of the various components of the translational machinery have been linked to several pathologies in the central nervous system. In this review, we provide a brief overview of the basic principles of mRNA translation, and discuss alterations of this process relevant to CNS disease conditions, with a focus on brain tumors and chronic neurological conditions. Finally, synthesizing this knowledge, we discuss the opportunities to exploit the biology of altered mRNA translation for novel therapies in brain disorders, as well as how studying these alterations can shed new light on disease mechanisms.
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Metadata
Title
Translational control in brain pathologies: biological significance and therapeutic opportunities
Authors
Alberto Delaidelli
Asad Jan
Jochen Herms
Poul H. Sorensen
Publication date
01-04-2019
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 4/2019
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-019-01971-8

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