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EJNMMI Research

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Open Access 01-12-2011 | Original research

Brain perfusion CT compared with¹⁵O-H₂O-PET in healthy subjects

Authors: Julie Marie Grüner, Rune Paamand, Liselotte Højgaard, Ian Law

Published in: EJNMMI Research | Issue 1/2011

Abstract

Background

Regional cerebral blood flow [rCBF] measurements are valuable for identifying angiogenically active tumours, and perfusion computed tomography [CT] has been suggested for that purpose. This study aimed to validate rCBF measurements by perfusion CT with positron-emission tomography [PET] and¹⁵O-labelled water [¹⁵O-H₂O] in healthy subjects.

Methods

RCBF was measured twice in 12 healthy subjects with¹⁵O-H₂O PET and once with perfusion CT performed over the basal ganglia. Matching rCBF values in regions of interest were compared.

Results

Measured with perfusion CT, rCBF was significantly and systematically overestimated. White matter rCBF values were 17.4 ± 2.0 (mean ± SD) mL min^-1 100 g^-1 for PET and 21.8 ± 3.4 mL min^-1 100 g^-1 for perfusion CT. Grey matter rCBF values were 48.7 ± 5.0 mL min^-1 100 g^-1 for PET and 71.8 ± 8.0 mL min^-1 100 g^-1 for perfusion CT. The overestimation of grey matter rCBF could be reduced from 47% to 20% after normalization to white matter rCBF, but the difference was still significant.

Conclusion

RCBF measured with perfusion CT does contain perfusion information, but neither quantitative nor relative values can substitute rCBF measured by¹⁵O-H₂O PET yet. This, however, does not necessarily preclude a useful role in patient management.

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Title: Brain perfusion CT compared with15O-H2O-PET in healthy subjects
Authors: Julie Marie Grüner
Rune Paamand
Liselotte Højgaard
Ian Law
Publication date: 01-12-2011
Publisher: Springer Berlin Heidelberg
Published in: EJNMMI Research / Issue 1/2011
Electronic ISSN: 2191-219X
DOI: https://doi.org/10.1186/2191-219X-1-28

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Brain perfusion CT compared with¹⁵O-H₂O-PET in healthy subjects

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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