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01-12-2013 | Original Paper

Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior

Authors: Carlos Alberto Yasin Wayhs, Caroline Paula Mescka, Camila Simioni Vanzin, Graziela Schmitt Ribas, Gilian Guerreiro, Maurício Schüler Nin, Vanusa Manfredini, Helena Maria Tannhauser Barros, Carmen Regla Vargas

Published in: Metabolic Brain Disease | Issue 4/2013

Abstract

Diabetes mellitus is characterized by hyperglycemia resulting from defects on insulin secretion, insulin action, or both. It has recently become clear that the central nervous system is not spared from the deleterious effects of diabetes, since diabetic encephalopathy was recognized as a complication of this heterogeneous metabolic disorder. There is a well recognized association between depression and diabetes, once prevalence of depression in diabetic patients is higher than in general population, and clonazepam is being used to treat this complication. Oxidative stress is widely accepted as playing a key mediatory role in the development and progression of diabetes and its complications. In this work we analyzed DNA damage by comet assay and lipid damage in prefrontal cortex, hippocampus and striatum of streptozotocin-induced diabetic rats submitted to the forced swimming test. It was verified that the diabetic group presented DNA and lipid damage in the brain areas evaluated, when compared to the control groups. Additionally, a significant reduction of the DNA and lipid damage in animals treated with insulin and/or clonazepam was observed. These data suggest that the association of these two drugs could protect against DNA and lipid damage in diabetic rats submitted to the forced swimming test, an animal model of depression.

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Title: Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior
Authors: Carlos Alberto Yasin Wayhs
Caroline Paula Mescka
Camila Simioni Vanzin
Graziela Schmitt Ribas
Gilian Guerreiro
Maurício Schüler Nin
Vanusa Manfredini
Helena Maria Tannhauser Barros
Carmen Regla Vargas
Publication date: 01-12-2013
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 4/2013
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-013-9397-z

At a glance: The STEP trials

Springer Medicine

Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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