Top

Published in:

01-12-2024 | Botulinum Toxin | Case Report

Can photobiomodulation be an antidote to botulinum toxin?

Authors: Elen de Souza Tolentino, Camila Camarini, Giovana Felipe Hara, Fernanda Vessoni Iwaki, Aline Thomazelli Peres Tomazoli

Published in: Lasers in Dental Science | Issue 1/2024

Abstract

Purpose

Although botulinum toxin (BT) is a safe and well-established method for chemoimmobilization of facial muscles, undesired results can occur. The reversal of the effects of BT is poorly documented in the literature. This work describes how photobiomodulation (PBM) was used to reverse unwanted results from the application of BT to the lower face in a patient with aesthetic and functional complaints (asymmetry, difficulty speaking, whistling, eating, and controlling saliva).

Methods

PBM (808 nm, 100mW, 0.35 W/cm², 10.7 J/cm2) was performed on the upper and lower labial muscles and chin to reverse the BT applied 14 days ago. Irradiation was performed at each point with the laser tip in contact with the skin for 30 s at each point (3 J), totaling 72 J per session (20 points).

Results

After two sessions (one-week interval) of PBM, there was an improvement in lip movements, with restored function.

Conclusion

In the parameters used, PBM was able to reverse the effects of BT on the lower face.

Kroumpouzos G, Kassir M, Gupta M, Patil A, Goldust M (2021) Complications of Botulinum toxin A: an update review. J Cosmet Dermatol 20(6):1585–1590. https://doi.org/10.1111/jocd.14160CrossRefPubMed

Kassir M, Gupta M, Galadari H, Kroumpouzos G, Katsambas A, Lotti T, Vojvodic A, Grabbe S, Juchems E, Goldust M (2020) Complications of botulinum toxin and fillers: a narrative review. J Cosmet Dermatol 19(3):570–573. https://doi.org/10.1111/jocd.13266CrossRefPubMed

Münchau A, Bhatia KP (2000) Uses of botulinum toxin injection in medicine today. BMJ 320:161. https://doi.org/10.1136/bmj.320.7228.161CrossRefPubMedPubMedCentral

Field M, Splevins A, Picaut P, van der Schans M, Langenberg J, Noort D, Snyder D, Foster K (2018) AbobotulinumtoxinA (Dysport®), OnabotulinumtoxinA (Botox®), and IncobotulinumtoxinA (Xeomin®) neurotoxin content and potential implications for duration of response in patients. Toxins 10(12):535. https://doi.org/10.3390/toxins10120535CrossRefPubMedPubMedCentral

Yiannakopoulou E (2015) Serious and long-term adverse events associated with the therapeutic and cosmetic use of botulinum toxin. Pharmacology 95(1–2):65–69. https://doi.org/10.1159/000370245CrossRefPubMed

Choi YJ, Kim JS, Gil YC, Phetudom T, Kim HJ, Tansatit T, Hu KS (2014) Anatomical considerations regarding the location and boundary of the depressor anguli oris muscle with reference to botulinum toxin injection. Plast Reconstr Surg 134(5):917–921. https://doi.org/10.1097/PRS.0000000000000589CrossRefPubMed

Flynn TC (2010) Botulinum toxin: examining duration of effect in facial aesthetic applications. Am J Clin Dermatol 11(3):183–199. https://doi.org/10.2165/11530110-000000000-00000CrossRefPubMed

Grillo R, Ribeiro E, Chaves A, de Barros TEP (2020) Blepharoptosis treatment as a complication due to botulinum toxin application. Biomed Res Clin Pract 5:1–3. https://doi.org/10.15761/BRCP.1000205CrossRef

Omoigui S, Irene S (2005) Treatment of ptosis as a complication of botulinum toxin injection. Pain Med 6(2):149–151. https://doi.org/10.1111/j.1526-4637.2005.05029.xCrossRefPubMed

10.

Palma LF, Morimoto S, Serrano RV, Alvares CMA, Muñoz-Lora VRM, Campos L (2022) Muscle function recovery following botulinum toxin type A facial injections: a case managed with photobiomodulation therapy. J Lasers Med Sci 13:e54. https://doi.org/10.34172/jlms.2022.54CrossRefPubMedPubMedCentral

11.

Maldonado EQ, Morales EC, Herrera AH (2018) Uso del laser de baja potencia como coadyuvante en el tratamiento de lesiones periapicales. Revisión sistemática. Salud Uninorte 34(3):797–805. https://doi.org/10.14482/sun.34.3.617.05CrossRef

12.

Vassão PG, Toma RL, Antunes HK, Tucci HT, Renno AC (2016) Effects of photobiomodulation on the fatigue level in elderly women: an isokinetic dynamometry evaluation. Lasers Med Sci 31(2):275–282. https://doi.org/10.1007/s10103-015-1858-7CrossRefPubMed

13.

Batista MR, Estrela LA, Alves VMN, Motta AR, Furlan RMMM (2021) Immediate effects of red (660 nm) and infrared (808 nm) photobiomodulation therapy on fatigue of the orbicularis oris muscle: a randomized clinical study. Efeitos imediatos da fotobiomodulação com laser de baixa intensidade e comprimentos de onda vermelho (660 nm) e infravermelho (808 nm) na fadiga eletromiográfica do músculo orbicular da boca: estudo clínico randomizado. CoDAS 34(2):e20200363. https://doi.org/10.1590/2317-1782/20212020363CrossRefPubMedPubMedCentral

14.

Al-Johany SS, Alqahtani AS, Alqahtani FY, Alzahrani AH (2011) Evaluation of different esthetic smile criteria. Int J Prosthodont 24(1):64–70PubMed

15.

Khan M, Kazmi SMR, Khan FR, Samejo I (2020) Analysis of different characteristics of smile. BDJ Open 6:6. https://doi.org/10.1038/s41405-020-0032-xCrossRefPubMedPubMedCentral

16.

Auada Souto MP, Souto LRM (2021) An unusual adverse event of botulinum toxin injection in the lower face. J Cosmet Dermatol 20(5):1381–1384. https://doi.org/10.1111/jocd.13869CrossRefPubMed

17.

Simpson LL (1986) Molecular pharmacology of botulinum toxin and tetanus toxin. Annu Rev Pharmacol Toxicol 26:427–453. https://doi.org/10.1146/annurev.pa.26.040186.002235CrossRefPubMed

18.

Keller JE, Neale EA (2001) The role of the synaptic protein snap-25 in the potency of botulinum neurotoxin type A. J Biol Chem 276(16):13476–13482. https://doi.org/10.1074/jbc.M010992200CrossRefPubMed

19.

Carruthers A, Carruthers J (2005) Botulinum toxin type A. J Am Acad Dermatol 53(2):284–290. https://doi.org/10.1016/j.jaad.2005.03.060CrossRefPubMed

20.

Hexsel D, Mazzuco R, Dal’Forno T, Kraemer C, Lima MM, do Prado DZ (2007) Botulinum toxin for facial wrinkles: history and future. Expert Rev Dermatol 2(4):417–426. https://doi.org/10.1586/17469872.2.4.417CrossRef

21.

Hexsel D, Costa RO, Mazzuco R, Hexsel CL (2004) Efeitos adversos e complicações da toxina botulínica. In: Tratado de Medicina Estética, 2nd edn. Roca, São Paulo, pp 1373–1384

22.

Wieder JM, Moy RL (1998) Understanding botulinum toxin. Surgical anatomy of the frown, forehead, and periocular region. Dermatolol Surg 24(11):1172–1174CrossRef

23.

Young DL, Halstead LA (2014) Pyridostigmine for reversal of severe sequelae from botulinum toxin injection. J Voice 28(6):830–834. https://doi.org/10.1016/j.jvoice.2014.04.010CrossRefPubMed

24.

Leal-Junior EC, Vanin AA, Miranda EF, Carvalho PT, Dal Corso S, Bjordal JM (2015) Effect of phototherapy (low-level laser therapy and light-emitting diode therapy) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis. Lasers Med Sci 30(2):925–939. https://doi.org/10.1007/s10103-013-1465-4CrossRefPubMed

25.

de Almeida P, Lopes-Martins RA, De Marchi T, Tomazoni SS, Albertini R, Corrêa JC, Rossi RP, Machado GP, da Silva DP, Bjordal JM, Leal Junior EC (2012) Red (660 nm) and infrared (830 nm) low-level laser therapy in skeletal muscle fatigue in humans: what is better? Lasers Med Sci 27(2):453–458. https://doi.org/10.1007/s10103-011-0957-3CrossRefPubMed

26.

Ash C, Dubec M, Donne K, Bashford T (2017) Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods. Lasers Med Sci 32(8):1909–1918. https://doi.org/10.1007/s10103-017-2317-4CrossRefPubMedPubMedCentral

27.

Alves VMN, Furlan RMMM, Motta AR (2019) Immediate effects of photobiomodulation with low-level laser therapy on muscle performance: an integrative literature review. Rev CEFAC 21(4):e12019. https://doi.org/10.1590/1982-0216/201921412019CrossRef

28.

Ruthel G, Burnett JC, Nuss JE, Wanner LM, Tressler LE, Torres-Melendez E, Sandwick SJ, Retterer CJ, Bavari S (2011) Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors. Toxins 3(3):207–217. https://doi.org/10.3390/toxins3030207CrossRefPubMedPubMedCentral

29.

Trupti-Vijay G, Anuj-Paul M, Sukanya D, Subhadeep G, Arunima S, Ashutosh D (2023) Low-level laser therapy in the management of muscle fatigue caused after long endodontic procedure. J Clin Exp Dent 15(5):e390–e395. https://doi.org/10.4317/jced.60369CrossRef

30.

Bublitz C, Renno AC, Ramos RS, Assis L, Sellera CA, Trimer R, Borghi-Silva A, Arena R, Guizilini S (2016) Acute effects of low-level laser therapy irradiation on blood lactate and muscle fatigue perception in hospitalized patients with heart failure-a pilot study. Lasers Med Sci 31(6):1203–1209. https://doi.org/10.1007/s10103-016-1965-0CrossRefPubMed

31.

Rochkind S, Geuna S, Shainberg A (2009) Chapter 25: phototherapy in peripheral nerve injury: effects on muscle preservation and nerve regeneration. Int Rev Neurobiol 87:445–464. https://doi.org/10.1016/S0074-7742(09)87025-6CrossRefPubMed

32.

Majlesi G (2008) GaAs laser treatment of bilateral eyelid ptosis due to complication of botulinum toxin type A injection. Photomed Laser Surg 26(5):507–509. https://doi.org/10.1089/pho.2007.2114CrossRefPubMed

33.

Vieira WHB, Bezerra RM, Queiroz RAS, Maciel NFB, Parizotto NA, Ferraresi C (2014) Use of low-level laser therapy (808 nm) to muscle fatigue resistance: a randomized double-blind crossover trial. Photomed Laser Surg 32(12):678–685. https://doi.org/10.1089/pho.2014.3812CrossRef

Title: Can photobiomodulation be an antidote to botulinum toxin?
Authors: Elen de Souza Tolentino
Camila Camarini
Giovana Felipe Hara
Fernanda Vessoni Iwaki
Aline Thomazelli Peres Tomazoli
Publication date: 01-12-2024
Publisher: Springer International Publishing
Keywords: Botulinum Toxin
Laser
Published in: Lasers in Dental Science / Issue 1/2024
Electronic ISSN: 2367-2587
DOI: https://doi.org/10.1007/s41547-024-00214-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Can photobiomodulation be an antidote to botulinum toxin?

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2024

Correction to: Nd: YAG laser irradiation consequences on calcium and magnesium in human dental tissues

Correction to: Comparison of different doses of Er:YAG laser irradiation combined with MI-varnish on the inhibition of enamel demineralization

Correction to: Evaluating the efficiency of Er,Cr:YSGG laser for recycling of debonded stainless steel orthodontic brackets: an in vitro study

Laser-photobiomodulation on reactive oxygen species production in titanium disc-containig pre-osteoblast cells culture

Correction to: Photobiomodulation on “PC6” acupoint in controlling the gag reflex of children during intraoral mandibular radiography—a randomized clinical trial

Correction to: High power diode laser in the treatment of pyogenic granuloma in young patients