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Published in: Maxillofacial Plastic and Reconstructive Surgery 1/2016

Open Access 01-12-2016 | Editorial

Botulinum toxin related research in maxillofacial plastic and reconstructive surgery

Author: Tae-Geon Kwon

Published in: Maxillofacial Plastic and Reconstructive Surgery | Issue 1/2016

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Excerpt

Botulism caused by food poisoning was characterized by mydriasis and skeletal muscle paralysis, which was first described by Justinus Kerner in 1820 [1]. The cause of botulism was botulinum neurotoxin produced by anaerobic, spore-forming bacteria of the genus Clostridium [2]. Botulinum toxin (BTX) became to be the first medically applied toxin. The first clinical use of BTX was reported concerning the treatment of strabismus in ophthalmologic field in 1980 [3]. Nine years later, the Food and Drug Administration (FDA) approved the clinical application of BTX for adult strabismus and blepharospasm [4]. BTX inhibits acetylcholine exocytosis at neuromuscular junction of the preganglionic sympathetic/parasympathetic nerve fibers and postganglionic parasympathetic nerves [5]. …
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Metadata
Title
Botulinum toxin related research in maxillofacial plastic and reconstructive surgery
Author
Tae-Geon Kwon
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
Maxillofacial Plastic and Reconstructive Surgery / Issue 1/2016
Electronic ISSN: 2288-8586
DOI
https://doi.org/10.1186/s40902-016-0080-2

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