Published in:
Open Access
01-12-2016 | Editorial
Botulinum toxin related research in maxillofacial plastic and reconstructive surgery
Author:
Tae-Geon Kwon
Published in:
Maxillofacial Plastic and Reconstructive Surgery
|
Issue 1/2016
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Excerpt
Botulism caused by food poisoning was characterized by mydriasis and skeletal muscle paralysis, which was first described by Justinus Kerner in 1820 [
1]. The cause of botulism was botulinum neurotoxin produced by anaerobic, spore-forming bacteria of the genus
Clostridium [
2]. Botulinum toxin (BTX) became to be the first medically applied toxin. The first clinical use of BTX was reported concerning the treatment of strabismus in ophthalmologic field in 1980 [
3]. Nine years later, the Food and Drug Administration (FDA) approved the clinical application of BTX for adult strabismus and blepharospasm [
4]. BTX inhibits acetylcholine exocytosis at neuromuscular junction of the preganglionic sympathetic/parasympathetic nerve fibers and postganglionic parasympathetic nerves [
5]. …