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Diabetologia
Published in: Diabetologia 8/2010

01-08-2010 | Article

Bone status in adolescents with type 1 diabetes

Authors: A. P. Chobot, A. Haffke, J. Polanska, Z. P. Halaba, G. Deja, P. Jarosz-Chobot, W. Pluskiewicz

Published in: Diabetologia | Issue 8/2010

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Abstract

Aims

The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other disease-related and growth variables was analysed.

Methods

Group I consisted of 99 pubertal (Tanner ≥2) adolescents (49 female), aged 14.3 ± 2.5 years, diabetes duration 4.6 ± 2.3 years. Controls (group II) were 297 children, matched by sex and age, from a healthy population. The influence of glycated haemoglobin (current: HbA1cD; last year’s mean: HbA1cY; whole duration mean: HbA1cT), diabetes duration, percentage of life with disease and daily insulin requirement (DIR) on amplitude dependent speed of sound (Ad-SoS) at distal phalanges was studied.

Results

In comparison to the control group, adolescents with type 1 diabetes presented significantly higher BMI SDS (0.82 [95% CI 0.54, 1.10] vs −0.06 [95% CI −0.16, 0.04] p < 0.001) and lower Ad-SoS SDS (−0.34 [95% CI −0.57, −0.11] vs −0.03 [95% CI −0.15, 0.08], p < 0.05). No correlation between Ad-SoS SDS and sex, DIR or diabetes duration was observed. The lower Ad-SoS SDS reflects reduced bone status, and the reduction was significantly more marked in those patients whose HbA1cT was higher than 7.0% when compared with those whose HbA1cT was lower.

Conclusions

Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control.
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Metadata
Title
Bone status in adolescents with type 1 diabetes
Authors
A. P. Chobot
A. Haffke
J. Polanska
Z. P. Halaba
G. Deja
P. Jarosz-Chobot
W. Pluskiewicz
Publication date
01-08-2010
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 8/2010
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-010-1782-0

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