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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-05-2011 | Original Article

Bone metabolic activity in hyperostosis cranialis interna measured with ¹⁸F-fluoride PET

Authors: Jérôme J. Waterval, Thijs M. A. Van Dongen, Robert J. Stokroos, Jaap G. J. Teule, Gerrit J. Kemerink, Boudewijn Brans, Fred H. M. Nieman, Johannes J. Manni

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 5/2011

Abstract

Purpose

¹⁸F-Fluoride PET/CT is a relatively undervalued diagnostic test to measure bone metabolism in bone diseases. Hyperostosis cranialis interna (HCI) is a (hereditary) bone disease characterised by endosteal hyperostosis and osteosclerosis of the skull and the skull base. Bone overgrowth causes entrapment and dysfunction of several cranial nerves. The aim of this study is to compare standardised uptake values (SUVs) at different sites in order to quantify bone metabolism in the affected anatomical regions in HCI patients.

Methods

Nine affected family members, seven non-affected family members and nine non-HCI non-family members underwent ¹⁸F-fluoride PET/CT scans. SUVs were systematically measured in the different regions of interest: frontal bone, sphenoid bone, petrous bone and clivus. Moreover, the average ¹⁸F-fluoride uptake in the entire skull was measured by assessing the uptake in axial slides. Visual assessment of the PET scans of affected individuals was performed to discover the process of disturbed bone metabolism in HCI.

Results

¹⁸F-Fluoride uptake is statistically significantly higher in the sphenoid bone and clivus regions of affected family members. Visual assessment of the scans of HCI patients is relevant in detecting disease severity and the pattern of disturbed bone metabolism throughout life.

Conclusion

¹⁸F-Fluoride PET/CT is useful in quantifying the metabolic activity in HCI and provides information about the process of disturbed bone metabolism in this specific disorder. Limitations are a narrow window between normal and pathological activity and the influence of age. This study emphasises that ¹⁸F-fluoride PET/CT may also be a promising diagnostic tool for other metabolic bone disorders, even those with an indolent course.

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Title: Bone metabolic activity in hyperostosis cranialis interna measured with 18F-fluoride PET
Authors: Jérôme J. Waterval
Thijs M. A. Van Dongen
Robert J. Stokroos
Jaap G. J. Teule
Gerrit J. Kemerink
Boudewijn Brans
Fred H. M. Nieman
Johannes J. Manni
Publication date: 01-05-2011
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 5/2011
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-010-1655-2

At a glance: The STEP trials

Springer Medicine

Bone metabolic activity in hyperostosis cranialis interna measured with ¹⁸F-fluoride PET

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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