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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2009

Open Access 01-12-2009 | Research article

Bone mass in schizophrenia and normal populations across different decades of life

Authors: Jenn-Huei Renn, Nan-Ping Yang, Ching-Mo Chueh, Chih-Yuan Lin, Tsuo-Hung Lan, Pesus Chou

Published in: BMC Musculoskeletal Disorders | Issue 1/2009

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Abstract

Background

Chronic schizophrenic patients have been reported as having higher osteoporosis prevalence. Survey the bone mass among schizophrenic patients and compare with that of the local community population and reported data of the same country to figure out the distribution of bone mass among schizophrenic patients.

Methods

965 schizophrenic patients aged 20 years and over in Yuli Veterans Hospital and 405 members aged 20 and over of the community living in the same town as the institute received bone mass examination by a heel qualitative ultrasound (QUS) device. Bone mass distribution was stratified to analyzed and compared with community population.

Results

Schizophrenic patients have lower bone mass while they are young. But aging effect on bone mass cannot be seen. Accelerated bone mass loss during menopausal transition was not observed in the female schizophrenic patients as in the subjects of the community female population.

Conclusion

Schizophrenic patients have lower bone mass than community population since they are young. Further study to investigate the pathophysiological process is necessary to delay or avoid the lower bone mass in schizophrenia patients.
Appendix
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Literature
1.
Hui SL, Slemenda CW, Johnston CC: Age and bone mass as predictors of fracture in a prospective study. J Clin Invest. 1988, 81: 1804-1809. 10.1172/JCI113523.CrossRefPubMedPubMedCentral
2.
Consensus conference: Osteoporosis. JAMA. 1984, 252: 799-802. 10.1001/jama.252.6.799.CrossRef
3.
Cummings SR, Rubin SM, Black D: The future of hip fractures in the United States. Numbers, costs, and potential effects of postmenopausal estrogen. Clin Orthop Relat Res. 1990, 163-166.
4.
NIH Consensus Statement. Osteoporosis prevention, diagnosis, and therapy. (Statement NC ed.). 17 (1): 1-36.
5.
Rigotti NA, Neer RM, Jameson L: Osteopenia and bone fractures in a man with anorexia nervosa and hypogonadism. JAMA. 1986, 256: 385-388. 10.1001/jama.256.3.385.CrossRefPubMed
6.
Biller BM, Saxe V, Herzog DB, Rosenthal DI, Holzman S, Klibanski A: Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metab. 1989, 68: 548-554.CrossRefPubMed
7.
Newman MM, Halmi KA: Relationship of bone density to estradiol and cortisol in anorexia nervosa and bulimia. Psychiatry Res. 1989, 29: 105-112. 10.1016/0165-1781(89)90190-X.CrossRefPubMed
8.
Salisbury JJ, Mitchell JE: Bone mineral density and anorexia nervosa in women. Am J Psychiatry. 1991, 148: 768-774.CrossRefPubMed
9.
Halbreich U, Rojansky N, Palter S, Hreshchyshyn M, Kreeger J, Bakhai Y, Rosan R: Decreased bone mineral density in medicated psychiatric patients. Psychosom Med. 1995, 57: 485-491.CrossRefPubMed
10.
Abraham G, Friedman RH, Verghese C, de Leon J: Osteoporosis and schizophrenia: can we limit known risk factors?. Biol Psychiatry. 1995, 38: 131-132. 10.1016/0006-3223(95)00062-L.CrossRefPubMed
11.
Greenspan SL, Cheng S, Miller PD, Orwoll ES: Clinical performance of a highly portable, scanning calcaneal ultrasonometer. Osteoporos Int. 2001, 12: 391-398. 10.1007/s001980170108.CrossRefPubMed
12.
Meszaros S, Toth E, Ferencz V, Csupor E, Hosszu E, Horvath C: Calcaneous quantitative ultrasound measurements predicts vertebral fractures in idiopathic male osteoporosis. Joint Bone Spine. 2007, 74: 79-84. 10.1016/j.jbspin.2006.04.008.CrossRefPubMed
13.
Gonnelli S, Cepollaro C: The use of ultrasound in the assessment of bone status. J Endocrinol Invest. 2002, 25: 389-397.CrossRefPubMed
14.
Frost ML, Blake GM, Fogelman I: Quantitative ultrasound and bone mineral density are equally strongly associated with risk factors for osteoporosis. J Bone Miner Res. 2001, 16: 406-416. 10.1359/jbmr.2001.16.2.406.CrossRefPubMed
15.
Frost ML, Blake GM, Fogelman I: A comparison of fracture discrimination using calcaneal quantitative ultrasound and dual X-ray absorptiometry in women with a history of fracture at sites other than the spine and hip. Calcif Tissue Int. 2002, 71: 207-211. 10.1007/s00223-001-2074-y.CrossRefPubMed
16.
Cetin A, Erturk H, Celiker R, Sivri A, Hascelik Z: The role of quantitative ultrasound in predicting osteoporosis defined by dual X-ray absorptiometry. Rheumatol Int. 2001, 20: 55-59. 10.1007/PL00006857.CrossRefPubMed
17.
Dane C, Dane B, Cetin A, Erginbas M: The role of quantitative ultrasound in predicting osteoporosis defined by dual-energy X-ray absorptiometry in pre- and postmenopausal women. Climacteric. 2008, 11: 296-303. 10.1080/13697130802178471.CrossRefPubMed
18.
Mulleman D, Legroux-Gerot I, Duquesnoy B, Marchandise X, Delcambre B, Cortet B: Quantitative ultrasound of bone in male osteoporosis. Osteoporos Int. 2002, 13: 388-393. 10.1007/s001980200044.CrossRefPubMed
19.
Pocock NA, Culton NL, Gilbert GR, Hoy ML, Babicheva R, Chu JM, Lee KS, Freund J: Potential roles for quantitative ultrasound in the management of osteoporosis. Med J Aust. 2000, 173: 355-358.PubMed
20.
Hans D, Fuerst T, Lang T, Majumdar S, Lu Y, Genant HK, Gluer C: How can we measure bone quality?. Baillieres Clin Rheumatol. 1997, 11: 495-515. 10.1016/S0950-3579(97)80017-9.CrossRefPubMed
21.
Herd RJ, Blake GM, Miller CG, Parker JC, Fogelman I: The ultrasonic assessment of osteopenia as defined by dual X-ray absorptiometry. Br J Radiol. 1994, 67: 631-635.CrossRefPubMed
22.
Yang NP, Jen I, Chuang SY, Chen SH, Chou P: Screening for low bone mass with quantitative ultrasonography in a community without dual-energy X-ray absorptiometry: population-based survey. BMC Musculoskelet Disord. 2006, 7: 24-10.1186/1471-2474-7-24.CrossRefPubMedPubMedCentral
23.
Meyer JM, Lehman D: Bone mineral density in male schizophrenia patients: a review. Ann Clin Psychiatry. 2006, 18: 43-48. 10.1080/10401230500464687.CrossRefPubMed
24.
Delva NJ, Crammer JL, Jarzylo SV, Lawson JS, Owen JA, Sribney M, Weir BJ, Yendt ER: Osteopenia, pathological fractures, and increased urinary calcium excretion in schizophrenic patients with polydipsia. Biol Psychiatry. 1989, 26: 781-793. 10.1016/0006-3223(89)90119-4.CrossRefPubMed
25.
Rojansky N, Halbreich U, Rosan R, Wang K, Hreshchyshyn M: Hormonally-related osteoporosis in chronic psychiatric patients. Neuroendocrin Letters. 1990, 12: 304-
26.
Kutsuma K: [Bone histomorphometric study of the ilium in psychiatric patients with longterm administration of anti-psychiatric drugs]. Nippon Seikeigeka Gakkai Zasshi. 1993, 67: 583-590.PubMed
27.
Lacro JP, Jeste DV: Physical comorbidity and polypharmacy in older psychiatric patients. Biol Psychiatry. 1994, 36: 146-152. 10.1016/0006-3223(94)91220-3.CrossRefPubMed
28.
Klibanski A, Neer RM, Beitins IZ, Ridgway EC, Zervas NT, McArthur JW: Decreased bone density in hyperprolactinemic women. N Engl J Med. 1980, 303: 1511-1514.CrossRefPubMed
29.
Schlechte JA, Sherman B, Martin R: Bone density in amenorrheic women with and without hyperprolactinemia. J Clin Endocrinol Metab. 1983, 56: 1120-1123.CrossRefPubMed
30.
Ataya K, Mercado A, Kartaginer J, Abbasi A, Moghissi KS: Bone density and reproductive hormones in patients with neuroleptic-induced hyperprolactinemia. Fertil Steril. 1988, 50: 876-881.CrossRefPubMed
31.
Kartaginer J, Ataya K, Mercado A, Abbasi A: Osteoporosis associated with neuroleptic treatment. A case report. J Reprod Med. 1990, 35: 198-202.PubMed
32.
Naidoo U, Goff DC, Klibanski A: Hyperprolactinemia and bone mineral density: the potential impact of antipsychotic agents. Psychoneuroendocrinology. 2003, 28 (Suppl 2): 97-108. 10.1016/S0306-4530(02)00129-4.CrossRefPubMed
33.
de Leon J, Verghese C, Tracy JI, Josiassen RC, Simpson GM: Polydipsia and water intoxication in psychiatric patients: a review of the epidemiological literature. Biol Psychiatry. 1994, 35: 408-419. 10.1016/0006-3223(94)90008-6.CrossRefPubMed
34.
Lindholm J, Steiniche T, Rasmussen E, Thamsborg G, Nielsen IO, Brockstedt-Rasmussen H, Storm T, Hyldstrup L, Schou C: Bone disorder in men with chronic alcoholism: a reversible disease?. J Clin Endocrinol Metab. 1991, 73: 118-124.CrossRefPubMed
35.
Sowers MR, Jannausch M, McConnell D, Little R, Greendale GA, Finkelstein JS, Neer RM, Johnston J, Ettinger B: Hormone predictors of bone mineral density changes during the menopausal transition. J Clin Endocrinol Metab. 2006, 91: 1261-1267. 10.1210/jc.2005-1836.CrossRefPubMed
36.
Guthrie JR, Ebeling PR, Hopper JL, Barrett-Connor E, Dennerstein L, Dudley EC, Burger HG, Wark JD: A prospective study of bone loss in menopausal Australian-born women. Osteoporos Int. 1998, 8: 282-290. 10.1007/s001980050066.CrossRefPubMed
37.
Halbreich U, Palter S: Accelerated osteoporosis in psychiatric patients: possible pathophysiological processes. Schizophr Bull. 1996, 22: 447-454.CrossRefPubMed
38.
Levinson DF, Simpson FM: Antipsychotic drug side effects. 1987, Washington, DC: American Psychiatric Association
39.
O'Keane V, Meaney AM: Antipsychotic drugs: a new risk factor for osteoporosis in young women with schizophrenia?. J Clin Psychopharmacol. 2005, 25: 26-31. 10.1097/01.jcp.0000150223.31007.e0.CrossRefPubMed
40.
Liu-Seifert H, Kinon BJ, Ahl J, Lamberson S: Osteopenia associated with increased prolactin and aging in psychiatric patients treated with prolactin-elevating antipsychotics. Ann N Y Acad Sci. 2004, 1032: 297-298. 10.1196/annals.1314.044.CrossRefPubMed
41.
Bilici M, Cakirbay H, Guler M, Tosun M, Ulgen M, Tan U: Classical and atypical neuroleptics, and bone mineral density, in patients with schizophrenia. Int J Neurosci. 2002, 112: 817-828. 10.1080/00207450290025833.CrossRefPubMed
42.
Becker D, Liver O, Mester R, Rapoport M, Weizman A, Weiss M: Risperidone, but not olanzapine, decreases bone mineral density in female premenopausal schizophrenia patients. J Clin Psychiatry. 2003, 64: 761-766.CrossRefPubMed
43.
Miller KK: Management of hyperprolactinemia in patients receiving antipsychotics. CNS Spectr. 2004, 9: 28-32.PubMed
44.
Hamner M: The effects of atypical antipsychotics on serum prolactin levels. Ann Clin Psychiatry. 2002, 14: 163-173.CrossRefPubMed
Metadata
Title
Bone mass in schizophrenia and normal populations across different decades of life
Authors
Jenn-Huei Renn
Nan-Ping Yang
Ching-Mo Chueh
Chih-Yuan Lin
Tsuo-Hung Lan
Pesus Chou
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2009
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-10-1

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