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Published in: European Journal of Orthopaedic Surgery & Traumatology 4/2020

01-05-2020 | Bone Defect | Original Article

Bone integration in acetabular revision hip arthroplasty using equine-derived bone grafts: a retrospective study

Authors: Nicola Piolanti, Andrea Del Chiaro, Fabrizio Matassi, Lorenzo Nistri, Angelo Graceffa, Massimiliano Marcucci

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 4/2020

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Abstract

Purpose

During the last decade, total hip arthroplasty has become a common procedure performed in young patients, as well as elderly ones. This has led to an increase in total hip arthroplasty revisions. Loosening of primary components with associated bone loss represents the major cause of total hip arthroplasty revision. This study evaluates the safety and performance of an enzyme-deantigenic equine-derived bone graft material in acetabular defect reconstruction.

Methods

Records of 55 patients who were treated for Paprosky type II or III acetabular bone defects with arthroplasty revisions using equine-derived bone and followed for an average of 34 months (range from 24 to 48 months) were analyzed.

Results

Of the 55 revisions, 49 (89%) were regarded as successful, showing good osteointegration without signs of mobilization. Failures included six cases (11%) of mobilization: five cases of aseptic mobilization (9.1% of revisions, 83% of failures) and one case of septic mobilization (1.9% of revisions, 17% of failures). These results are consistent with those of studies having a similar follow-up period for allografts used in combination with trabecular metal components.

Conclusions

Results of the present study suggest that enzyme-treated equine-derived bone grafts may be a valid alternative to autogenous and homologous bone grafts in total hip arthroplasty revision.
Literature
1.
go back to reference Sadoghi P, Liebensteiner M, Agreiter M, Leithner A, Bohler N, Labek G (2013) Revision surgery after total joint arthroplasty: a complication-based analysis using worldwide arthroplasty registers. J Arthroplasty 28(8):1329–1332PubMedCrossRef Sadoghi P, Liebensteiner M, Agreiter M, Leithner A, Bohler N, Labek G (2013) Revision surgery after total joint arthroplasty: a complication-based analysis using worldwide arthroplasty registers. J Arthroplasty 28(8):1329–1332PubMedCrossRef
2.
go back to reference Beswick A, Blom AW (2011) Bone graft substitutes in hip revision surgery: a comprehensive overview. Injury 42(Suppl 2):S40–S46PubMedCrossRef Beswick A, Blom AW (2011) Bone graft substitutes in hip revision surgery: a comprehensive overview. Injury 42(Suppl 2):S40–S46PubMedCrossRef
3.
go back to reference Paprosky WG, Perona PG, Lawrence JM (1994) Acetabular defect classification and surgical reconstruction in revision arthroplasty. A 6-year follow-up evaluation. J Arthroplasty 9(1):33–44PubMedCrossRef Paprosky WG, Perona PG, Lawrence JM (1994) Acetabular defect classification and surgical reconstruction in revision arthroplasty. A 6-year follow-up evaluation. J Arthroplasty 9(1):33–44PubMedCrossRef
4.
go back to reference Goldberg VM (2000) Selection of bone grafts for revision total hip arthroplasty. Clin Orthop Relat Res 381:68–76CrossRef Goldberg VM (2000) Selection of bone grafts for revision total hip arthroplasty. Clin Orthop Relat Res 381:68–76CrossRef
5.
go back to reference Shibuya N, Jupiter DC (2015) Bone graft substitute: allograft and xenograft. Clin Podiatr Med Surg 32(1):21–34PubMedCrossRef Shibuya N, Jupiter DC (2015) Bone graft substitute: allograft and xenograft. Clin Podiatr Med Surg 32(1):21–34PubMedCrossRef
6.
go back to reference Pistilli R, Signorini L, Pisacane A, Lizio G, Felice P (2013) Case of severe bone atrophy of the posterior maxilla rehabilitated with blocks of equine origin bone: histological results. Implant Dent 22(1):8–15PubMedCrossRef Pistilli R, Signorini L, Pisacane A, Lizio G, Felice P (2013) Case of severe bone atrophy of the posterior maxilla rehabilitated with blocks of equine origin bone: histological results. Implant Dent 22(1):8–15PubMedCrossRef
7.
go back to reference Di Stefano DA, Greco GB, Riboli F (2016) Guided Bone Regeneration of an Atrophic Mandible with a Heterologous Bone Block. Craniomaxillofac Trauma Reconstr 9(1):88–93PubMedCrossRef Di Stefano DA, Greco GB, Riboli F (2016) Guided Bone Regeneration of an Atrophic Mandible with a Heterologous Bone Block. Craniomaxillofac Trauma Reconstr 9(1):88–93PubMedCrossRef
8.
go back to reference Mattioli B, Iacoviello P, Aldiano C, Verrina G (2018) Subcranial Le Fort III advancement with equine-derived bone grafts to correct syndromic midfacial hypoplasia: a case report. J Maxillofac Oral Surg 17(3):296–300PubMedCrossRef Mattioli B, Iacoviello P, Aldiano C, Verrina G (2018) Subcranial Le Fort III advancement with equine-derived bone grafts to correct syndromic midfacial hypoplasia: a case report. J Maxillofac Oral Surg 17(3):296–300PubMedCrossRef
9.
go back to reference Santini S, Barbera P, Modena M, Schiavon R, Bonato M (2011) Equine-derived bone substitutes in orthopedics and traumatology: authors' experience. Minerva Chir 66(1):63–72PubMed Santini S, Barbera P, Modena M, Schiavon R, Bonato M (2011) Equine-derived bone substitutes in orthopedics and traumatology: authors' experience. Minerva Chir 66(1):63–72PubMed
10.
go back to reference Sonmez MM, Armagan R, Ugurlar M, Eren T (2017) Allografts versus Equine Xenografts in Calcaneal Fracture Repair. J Foot Ankle Surg 56(3):510–513PubMedCrossRef Sonmez MM, Armagan R, Ugurlar M, Eren T (2017) Allografts versus Equine Xenografts in Calcaneal Fracture Repair. J Foot Ankle Surg 56(3):510–513PubMedCrossRef
12.
go back to reference Russo R, Maiotti M, Taverna E, Rao C (2018) Arthroscopic bone graft procedure combined with arthroscopic subscapularis augmentation for recurrent anterior instability with glenoid bone defect. Arthrosc Tech 7(6):e623–e632PubMedPubMedCentralCrossRef Russo R, Maiotti M, Taverna E, Rao C (2018) Arthroscopic bone graft procedure combined with arthroscopic subscapularis augmentation for recurrent anterior instability with glenoid bone defect. Arthrosc Tech 7(6):e623–e632PubMedPubMedCentralCrossRef
13.
go back to reference Russo R, Maiotti M, Taverna E (2018) Arthroscopic bone graft procedure combined with arthroscopic subscapularis augmentation (ASA) for recurrent anterior instability with glenoid bone defect: a cadaver study. J Exp Orthop 5(1):5PubMedPubMedCentralCrossRef Russo R, Maiotti M, Taverna E (2018) Arthroscopic bone graft procedure combined with arthroscopic subscapularis augmentation (ASA) for recurrent anterior instability with glenoid bone defect: a cadaver study. J Exp Orthop 5(1):5PubMedPubMedCentralCrossRef
14.
go back to reference Da Rin F (2017) Treating a recalcitrant non-union of the radius using autogenous bone, equine bone paste, equine demineralized bone matrix, platelet rich plasma and bone marrow aspirate. A case report. J Orthop Case Rep 7(6):31–5 Da Rin F (2017) Treating a recalcitrant non-union of the radius using autogenous bone, equine bone paste, equine demineralized bone matrix, platelet rich plasma and bone marrow aspirate. A case report. J Orthop Case Rep 7(6):31–5
16.
go back to reference DeLee JG, Charnley J (1976) Radiological demarcation of cemented sockets in total hip replacement. Clin Orthop Relat Res 121:20–32 DeLee JG, Charnley J (1976) Radiological demarcation of cemented sockets in total hip replacement. Clin Orthop Relat Res 121:20–32
17.
go back to reference Sutherland CJ, Wilde AH, Borden LS, Marks KE (1982) A ten-year follow-up of one hundred consecutive Muller curved-stem total hip-replacement arthroplasties. J Bone Joint Surg Am 64(7):970–982PubMedCrossRef Sutherland CJ, Wilde AH, Borden LS, Marks KE (1982) A ten-year follow-up of one hundred consecutive Muller curved-stem total hip-replacement arthroplasties. J Bone Joint Surg Am 64(7):970–982PubMedCrossRef
18.
go back to reference Callaghan JJ, Salvati EA, Pellicci PM, Wilson PD Jr, Ranawat CS (1985) Results of revision for mechanical failure after cemented total hip replacement, 1979 to 1982 A two to five-year follow-up. J Bone Joint Surg Am 67(7):1074–1085PubMedCrossRef Callaghan JJ, Salvati EA, Pellicci PM, Wilson PD Jr, Ranawat CS (1985) Results of revision for mechanical failure after cemented total hip replacement, 1979 to 1982 A two to five-year follow-up. J Bone Joint Surg Am 67(7):1074–1085PubMedCrossRef
19.
go back to reference Yoshino K, Tsukeoka T, Tsuneizumi Y, Lee TH, Nakamura J, Suzuki M et al (2017) Revision total hip arthroplasty using a cementless cup supporter and iliac autograft: a minimum of 15-year follow-up. J Arthroplasty 32(11):3495–3501PubMedCrossRef Yoshino K, Tsukeoka T, Tsuneizumi Y, Lee TH, Nakamura J, Suzuki M et al (2017) Revision total hip arthroplasty using a cementless cup supporter and iliac autograft: a minimum of 15-year follow-up. J Arthroplasty 32(11):3495–3501PubMedCrossRef
20.
go back to reference Kim Y, Tanaka C, Kanoe H (2015) Long-term outcome of acetabular reconstruction using a Kerboull-type acetabular reinforcement device with hydroxyapetite granule and structural autograft for AAOS type II and III acetabular defects. J Arthroplasty 30(10):1810–1814PubMedCrossRef Kim Y, Tanaka C, Kanoe H (2015) Long-term outcome of acetabular reconstruction using a Kerboull-type acetabular reinforcement device with hydroxyapetite granule and structural autograft for AAOS type II and III acetabular defects. J Arthroplasty 30(10):1810–1814PubMedCrossRef
21.
go back to reference Hinsenkamp M, Muylle L, Eastlund T, Fehily D, Noel L, Strong DM (2012) Adverse reactions and events related to musculoskeletal allografts: reviewed by the World Health Organisation Project NOTIFY. Int Orthop 36(3):633–641PubMedCrossRef Hinsenkamp M, Muylle L, Eastlund T, Fehily D, Noel L, Strong DM (2012) Adverse reactions and events related to musculoskeletal allografts: reviewed by the World Health Organisation Project NOTIFY. Int Orthop 36(3):633–641PubMedCrossRef
22.
go back to reference Fillingham Y, Jacobs J (2016) Bone grafts and their substitutes. Bone Joint J 98-B(1 Suppl A):6–9PubMedCrossRef Fillingham Y, Jacobs J (2016) Bone grafts and their substitutes. Bone Joint J 98-B(1 Suppl A):6–9PubMedCrossRef
23.
go back to reference Liu Q, Huang S, Matinlinna JP, Chen Z, Pan H (2013) Insight into biological apatite: physiochemical properties and preparation approaches. Biomed Res Int 2013:929748PubMedPubMedCentral Liu Q, Huang S, Matinlinna JP, Chen Z, Pan H (2013) Insight into biological apatite: physiochemical properties and preparation approaches. Biomed Res Int 2013:929748PubMedPubMedCentral
24.
go back to reference Cusinato R, Pacenti M, Martello T, Fattori P, Morroni M, Palu G (2016) Effectiveness of hydrogen peroxide and electron-beam irradiation treatment for removal and inactivation of viruses in equine-derived xenografts. J Virol Methods 232:39–46PubMedCrossRef Cusinato R, Pacenti M, Martello T, Fattori P, Morroni M, Palu G (2016) Effectiveness of hydrogen peroxide and electron-beam irradiation treatment for removal and inactivation of viruses in equine-derived xenografts. J Virol Methods 232:39–46PubMedCrossRef
25.
go back to reference Zhang J (2011) The structural stability of wild-type horse prion protein. J Biomol Struct Dyn 29(2):369–377PubMedCrossRef Zhang J (2011) The structural stability of wild-type horse prion protein. J Biomol Struct Dyn 29(2):369–377PubMedCrossRef
26.
go back to reference Khan MQ, Sweeting B, Mulligan VK, Arslan PE, Cashman NR, Pai EF et al (2010) Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP. Proc Natl Acad Sci USA 107(46):19808–19813PubMedCrossRef Khan MQ, Sweeting B, Mulligan VK, Arslan PE, Cashman NR, Pai EF et al (2010) Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP. Proc Natl Acad Sci USA 107(46):19808–19813PubMedCrossRef
27.
go back to reference Perez DR, Damberger FF, Wuthrich K (2010) Horse prion protein NMR structure and comparisons with related variants of the mouse prion protein. J Mol Biol 400(2):121–128PubMedCrossRef Perez DR, Damberger FF, Wuthrich K (2010) Horse prion protein NMR structure and comparisons with related variants of the mouse prion protein. J Mol Biol 400(2):121–128PubMedCrossRef
28.
go back to reference Giachin G, Biljan I, Ilc G, Plavec J, Legname G (2013) Probing early misfolding events in prion protein mutants by NMR spectroscopy. Molecules 18(8):9451–9476PubMedPubMedCentralCrossRef Giachin G, Biljan I, Ilc G, Plavec J, Legname G (2013) Probing early misfolding events in prion protein mutants by NMR spectroscopy. Molecules 18(8):9451–9476PubMedPubMedCentralCrossRef
29.
go back to reference Charalambides C, Beer M, Cobb AG (2005) Poor results after augmenting autograft with xenograft (Surgibone) in hip revision surgery: a report of 27 cases. Acta Orthop 76(4):544–549PubMedCrossRef Charalambides C, Beer M, Cobb AG (2005) Poor results after augmenting autograft with xenograft (Surgibone) in hip revision surgery: a report of 27 cases. Acta Orthop 76(4):544–549PubMedCrossRef
30.
go back to reference Artese L, Piattelli A, Di Stefano DA, Piccirilli M, Pagnutti S, D'Alimonte E et al (2011) Sinus lift with autologous bone alone or in addition to equine bone: an immunohistochemical study in man. Implant dentistry 20(5):383–388PubMed Artese L, Piattelli A, Di Stefano DA, Piccirilli M, Pagnutti S, D'Alimonte E et al (2011) Sinus lift with autologous bone alone or in addition to equine bone: an immunohistochemical study in man. Implant dentistry 20(5):383–388PubMed
31.
go back to reference Di Stefano DA, Gastaldi G, Vinci R, Cinci L, Pieri L, Gherlone E (2015) Histomorphometric comparison of enzyme-deantigenic equine bone and anorganic bovine bone in sinus augmentation: a randomized clinical trial with 3-year follow-up. Int J Oral Maxillofac Implants 30(5):1161–1167PubMedCrossRef Di Stefano DA, Gastaldi G, Vinci R, Cinci L, Pieri L, Gherlone E (2015) Histomorphometric comparison of enzyme-deantigenic equine bone and anorganic bovine bone in sinus augmentation: a randomized clinical trial with 3-year follow-up. Int J Oral Maxillofac Implants 30(5):1161–1167PubMedCrossRef
32.
go back to reference Di Stefano DA, Gastaldi G, Vinci R, Polizzi EM, Cinci L, Pieri L et al (2016) Bone formation following sinus augmentation with an equine-derived bone graft: a retrospective histologic and histomorphometric study with 36-month follow-up. Int J Oral Maxillofac Implants 31(2):406–412PubMedCrossRef Di Stefano DA, Gastaldi G, Vinci R, Polizzi EM, Cinci L, Pieri L et al (2016) Bone formation following sinus augmentation with an equine-derived bone graft: a retrospective histologic and histomorphometric study with 36-month follow-up. Int J Oral Maxillofac Implants 31(2):406–412PubMedCrossRef
33.
go back to reference Di Stefano DA, Zaniol T, Cinci L, Pieri L (2019) Chemical, clinical and histomorphometric comparison between equine bone manufactured through enzymatic antigen-elimination and bovine bone made non-antigenic using a high-temperature process in post-extractive socket grafting. A comparative retrospective clinical study. Dent J 7(3):70CrossRef Di Stefano DA, Zaniol T, Cinci L, Pieri L (2019) Chemical, clinical and histomorphometric comparison between equine bone manufactured through enzymatic antigen-elimination and bovine bone made non-antigenic using a high-temperature process in post-extractive socket grafting. A comparative retrospective clinical study. Dent J 7(3):70CrossRef
34.
go back to reference La Monaca G, Iezzi G, Cristalli MP, Pranno N, Sfasciotti GL, Vozza I (2018) Comparative histological and histomorphometric results of six biomaterials used in two-stage maxillary sinus augmentation model after 6-month healing. Biomed Res Int 2018:9430989PubMedPubMedCentralCrossRef La Monaca G, Iezzi G, Cristalli MP, Pranno N, Sfasciotti GL, Vozza I (2018) Comparative histological and histomorphometric results of six biomaterials used in two-stage maxillary sinus augmentation model after 6-month healing. Biomed Res Int 2018:9430989PubMedPubMedCentralCrossRef
35.
go back to reference Rosito R, Galia CR, Macedo CA, Moreira LF, Quaresma LM, Palma HM (2008) Acetabular reconstruction with human and bovine freeze-dried bone grafts and a reinforcement device. Clinics (Sao Paulo) 63(4):509–514CrossRef Rosito R, Galia CR, Macedo CA, Moreira LF, Quaresma LM, Palma HM (2008) Acetabular reconstruction with human and bovine freeze-dried bone grafts and a reinforcement device. Clinics (Sao Paulo) 63(4):509–514CrossRef
36.
go back to reference Diesel CV, Ribeiro TA, Guimaraes MR, Macedo CAS, Galia CR (2017) Acetabular revision in total hip arthroplasty with tantalum augmentation and lyophilized bovine xenograft. Revista brasileira de ortopedia 52(Suppl 1):46–51PubMedPubMedCentral Diesel CV, Ribeiro TA, Guimaraes MR, Macedo CAS, Galia CR (2017) Acetabular revision in total hip arthroplasty with tantalum augmentation and lyophilized bovine xenograft. Revista brasileira de ortopedia 52(Suppl 1):46–51PubMedPubMedCentral
37.
go back to reference Molicnik A, Hanc M, Recnik G, Krajnc Z, Rupreht M, Fokter SK (2014) Porous tantalum shells and augments for acetabular cup revisions. Eur J Orthop Surg Traumatol 24(6):911–917PubMedCrossRef Molicnik A, Hanc M, Recnik G, Krajnc Z, Rupreht M, Fokter SK (2014) Porous tantalum shells and augments for acetabular cup revisions. Eur J Orthop Surg Traumatol 24(6):911–917PubMedCrossRef
38.
go back to reference Pierannunzii L, Mambretti A, D'Imporzano M (2011) Trabecular metal cup without augments for acetabular revision in case of extensive bone loss and low bone-prosthesis contact. Int J Immunopathol Pharmacol 24(1 Suppl 2):133–137PubMedCrossRef Pierannunzii L, Mambretti A, D'Imporzano M (2011) Trabecular metal cup without augments for acetabular revision in case of extensive bone loss and low bone-prosthesis contact. Int J Immunopathol Pharmacol 24(1 Suppl 2):133–137PubMedCrossRef
39.
go back to reference Perrotti V, Nicholls BM, Piattelli A (2009) Human osteoclast formation and activity on an equine spongy bone substitute. Clin Oral Implants Res 20(1):17–23PubMedCrossRef Perrotti V, Nicholls BM, Piattelli A (2009) Human osteoclast formation and activity on an equine spongy bone substitute. Clin Oral Implants Res 20(1):17–23PubMedCrossRef
40.
go back to reference Regazzoni C, Winterhalter KH, Rohrer L (2001) Type I collagen induces expression of bone morphogenetic protein receptor type II. Biochem Biophys Res Commun 283(2):316–322PubMedCrossRef Regazzoni C, Winterhalter KH, Rohrer L (2001) Type I collagen induces expression of bone morphogenetic protein receptor type II. Biochem Biophys Res Commun 283(2):316–322PubMedCrossRef
41.
go back to reference Basle MF, Lesourd M, Grizon F, Pascaretti C, Chappard D (1998) Type I collagen in xenogenic bone material regulates attachment and spreading of osteoblasts over the beta1 integrin subunit. Der Orthop 27(2):136–142 Basle MF, Lesourd M, Grizon F, Pascaretti C, Chappard D (1998) Type I collagen in xenogenic bone material regulates attachment and spreading of osteoblasts over the beta1 integrin subunit. Der Orthop 27(2):136–142
42.
go back to reference Mordenfeld A, Hallman M, Johansson CB, Albrektsson T (2010) Histological and histomorphometrical analyses of biopsies harvested 11 years after maxillary sinus floor augmentation with deproteinized bovine and autogenous bone. Clin Oral Implants Res 21(9):961–970PubMed Mordenfeld A, Hallman M, Johansson CB, Albrektsson T (2010) Histological and histomorphometrical analyses of biopsies harvested 11 years after maxillary sinus floor augmentation with deproteinized bovine and autogenous bone. Clin Oral Implants Res 21(9):961–970PubMed
Metadata
Title
Bone integration in acetabular revision hip arthroplasty using equine-derived bone grafts: a retrospective study
Authors
Nicola Piolanti
Andrea Del Chiaro
Fabrizio Matassi
Lorenzo Nistri
Angelo Graceffa
Massimiliano Marcucci
Publication date
01-05-2020
Publisher
Springer Paris
Published in
European Journal of Orthopaedic Surgery & Traumatology / Issue 4/2020
Print ISSN: 1633-8065
Electronic ISSN: 1432-1068
DOI
https://doi.org/10.1007/s00590-019-02613-1

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