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Open Access 01-10-2011 | Original Article

Body mass index is not a predictor of biochemical recurrence after radical prostatectomy in Dutch men diagnosed with prostate cancer

Authors: Dieuwertje E. G. Kok, Joep G. H. van Roermund, Katja K. Aben, Moniek W. M. van de Luijtgaarden, Herbert F. M. Karthaus, Oncko B. van Vierssen Trip, Ellen Kampman, J. Alfred Witjes, Lambertus A. L. M. Kiemeney

Published in: World Journal of Urology | Issue 5/2011

Abstract

Purpose

To determine the effect of body mass index (BMI) on clinical and pathological characteristics at time of diagnosis and on risk of biochemical recurrence after radical prostatectomy among Dutch men diagnosed with prostate cancer.

Methods

In total, 1,116 prostate cancer patients with known BMI, diagnosed between 2003 and 2006, were identified from the population-based cancer registry held by the Comprehensive Cancer Centre East, The Netherlands. Of these, 504 patients underwent a radical prostatectomy. Patients were categorized as normal weight (BMI < 25 kg/m²), overweight (BMI 25–30 kg/m²), or obese (BMI ≥ 30 kg/m²). Multivariable proportional hazards regression models, adjusted for age, prediagnostic PSA levels, and pathological characteristics were used to evaluate BMI as a prognostic factor for biochemical recurrence after radical prostatectomy.

Results

Overall, clinical and biopsy characteristics did not significantly differ among BMI groups. Pathological characteristics after radical prostatectomy did not significantly differ among BMI groups, except for tumor stage, which was highest in obese patients (P = 0.017). For patients treated with radical prostatectomy, 5-year risk (95% Confidence Intervals) of biochemical recurrence was 30% (23–37%) for normal weight, 32% (25–39%) for overweight, and 25% (9–41%) for obese patients (log rank P = 0.810). BMI was not an independent prognostic factor for biochemical recurrence in multivariable proportional hazards regression analyses (HR 0.99 per kg/m², 95% CI: 0.93–1.06).

Conclusions

Compared with non-obese men, pathological tumor stage tended to be higher in obese men. Clinical relevance of this finding is unclear, because BMI was not an independent predictor of biochemical recurrence after radical prostatectomy.

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Title: Body mass index is not a predictor of biochemical recurrence after radical prostatectomy in Dutch men diagnosed with prostate cancer
Authors: Dieuwertje E. G. Kok
Joep G. H. van Roermund
Katja K. Aben
Moniek W. M. van de Luijtgaarden
Herbert F. M. Karthaus
Oncko B. van Vierssen Trip
Ellen Kampman
J. Alfred Witjes
Lambertus A. L. M. Kiemeney
Publication date: 01-10-2011
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 5/2011
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-010-0629-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Body mass index is not a predictor of biochemical recurrence after radical prostatectomy in Dutch men diagnosed with prostate cancer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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