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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-12-2015 | Glaucoma

Blue–yellow and standard pattern visual evoked potentials in phakic and pseudophakic glaucoma patients and controls

Authors: Matthias Fuest, Jule Kieckhoefel, Babac Mazinani, David Kuerten, Antonis Koutsonas, Eva Koch, Peter Walter, Niklas Plange

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2015

Abstract

Purpose

Blue–yellow short wavelength testing (BY-VEPs) has proven diagnostic relevance in detecting early ganglion cell damage, e.g., in glaucoma. To date testing has generally been conducted using individual protocols without consideration of the lens status. In this study, we compared changes in BY-VEPs and standard pattern VEPs in phakic and pseudophakic glaucoma patients and controls.

Methods

The eyes of 57 healthy controls (18 pseudophakic and 39 phakic) and 67 glaucoma patients (29 pseudophakic and 38 phakic) were included in a prospective study. Phakic eyes were arranged in three groups according to the Lens Opacities Classification System III. Transient on/off isoluminant blue–yellow 2° checks were used for BY-VEPs, transient large 1° (M1) and small 0.25° (M2) black–white checks for standard pattern reversal VEPs, according to the ISCEV standards.

Results

Latencies and amplitudes of M1 and M2 did not differ significantly between groups or lens status. ANOVA analysis revealed significantly longer BY-VEP latencies in glaucoma compared to controls (p = 0.002), independently of the lens status. The amplitudes showed no such pattern (p = 0.93).

Mean defect (MD) was significantly negatively correlated to BY-VEP latency (r = −0.54, p = 0.003) only in pseudophakic glaucoma patients. Different stages of cataract did not show a significant effect on the BY-VEP latencies.

Conclusions

Glaucoma led to a significant increase of BY-VEPs latencies, while standard pattern VEPs were not influenced. The correlation of MD and BY-VEP latency only in pseudophakic glaucoma patients indicates a substantial confounding effect of lens opacifications on the diagnostic value of BY-VEPs in glaucoma.

Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL, Tormene AP, Vaegan (2010) ISCEV standard for clinical visual evoked potentials (2009 update). Doc Ophthalmol 120(1):111–119. doi:10.1007/s10633-009-9195-4 CrossRefPubMed

Regan D (1989) Human brain electrophysiology: evoked potentials and evoked magnetic fields in science and medicine, vol xxiv. Elsevier, New York, 672 p

Lennie P, D’Zmura M (1988) Mechanisms of color vision. Crit Rev Neurobiol 3(4):333–400PubMed

Yucel YH, Zhang Q, Weinreb RN, Kaufman PL, Gupta N (2003) Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog Retin Eye Res 22(4):465–481CrossRefPubMed

Crognale MA, Switkes E, Rabin J, Schneck ME, Haegerstrom-Portnoy G, Adams AJ (1993) Application of the spatiochromatic visual evoked potential to detection of congenital and acquired color-vision deficiencies. J Opt Soc Am A Opt Image Sci Vis 10(8):1818–1825CrossRefPubMed

Schneck M, Lee E, Fortune B, Crognale M, Adams A, Switkes E (1997) Spatio-chromatic VEPS in recovered optic neuritis and multiple sclerosis. In: Cavonius CR (ed) Colour vision deficiencies XIII, vol 59. Documenta Ophthalmologica Proceedings Series. Springer, Netherlands, pp 179–185. doi:10.1007/978-94-011-5408-6_18

Crognale M, Rabin J, Switkes E, Adams AJ (1993) Selective loss of S-pathway sensitivity in central serous choroidopathy revealed by spatio-chromatic visual evoked cortical potentials (VECP). In: Drum B (ed) Colour vision deficiencies XI, vol 56. Documenta Ophthalmologica Proceedings Series. Springer, Netherlands, pp 229–239. doi:10.1007/978-94-011-1856-9_23

Johnson CA, Adams AJ, Casson EJ, Brandt JD (1993) Blue-on-yellow perimetry can predict the development of glaucomatous visual field loss. Arch Ophthalmol 111(5):645–650CrossRefPubMed

Horn FK, Jonas JB, Budde WM, Junemann AM, Mardin CY, Korth M (2002) Monitoring glaucoma progression with visual evoked potentials of the blue-sensitive pathway. Invest Ophthalmol Vis Sci 43(6):1828–1834PubMed

10.

Copenhaver RM, Perry NW Jr (1964) Factors affecting visually evoked cortical potentials such as impaired vision of varying etiology. Invest Ophthalmol 3:665–675PubMed

11.

Crognale MA (2002) Development, maturation, and aging of chromatic visual pathways: VEP results. J Vis 2(6):438–450. doi:10.1167/2.6.2 CrossRefPubMed

12.

Fuest M, Plange N, Jamali S, Schwarzer H, Roessler G, Walter P, Mazinani B (2014) The effect of cataract surgery on blue–yellow and standard-pattern visual-evoked potentials. Graefe’s Arch Clin Exp Ophthalmol 252(11):1831–1837. doi:10.1007/s00417-014-2728-x CrossRef

13.

European Glaucoma Society [EGS] (2008) Terminology and guidelines for glaucoma, 3rd edn. European Glaucoma Society, Savona Italy

14.

Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY (1993) The lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol 111(6):831–836CrossRefPubMed

15.

Epstein CM, Bej MD, Foldvary-Schaefer N, Lagerlund TD, Helmers SL, Husain AM (2006) Guideline 5: guidelines for standard electrode position nomenclature (American Clinical Neurophysiology Society). J Clin Neurophysiol 23(2):107–110CrossRef

16.

Porciatti V, Di Bartolo E, Nardi N, Fiorentini A (1997) Responses to chromatic and luminance contrast in glaucoma: a psychophysical and electrophysiological study. Vis Res 37(14):1975–1987CrossRefPubMed

17.

Nguyen XN, Korth M, Rix R, Sembritzki O (1993) [Blue-sensitive mechanisms in pattern ERG and VEP]. Ophthalmologe 90(2):143–147 (article in German)PubMed

18.

Musch DC, Gillespie BW, Niziol LM, Janz NK, Wren PA, Rockwood EJ, Lichter PR (2006) Cataract extraction in the collaborative initial glaucoma treatment study: incidence, risk factors, and the effect of cataract progression and extraction on clinical and quality-of-life outcomes. Arch Ophthalmol 124(12):1694–1700. doi:10.1001/archopht.124.12.1694 CrossRefPubMed

19.

van Lith GHM, Hekkert-Wiebenga W (1983) Cataract, pattern stimulation and visually evoked potentials. Doc Ophthalmol 55(1–2):107–112. doi:10.1007/bf00140467 CrossRefPubMed

20.

Chelva E, van Lith GHM (1982) Influence of defocusing, absorption and scatter on evoked potentials to contrast and contour related stimuli. Doc Ophthalmol 31:337–344

21.

Ho WC, Chu PH, Ng YF, Tong PP, Woo VC, Chan HH (2012) Temporal interactive response is resistant to cloudy ocular media in the slow double-stimulation multifocal electroretinogram. Br J Ophthalmol 96(7):1012–1017. doi:10.1136/bjophthalmol-2011-301099 CrossRefPubMed

22.

Kubova Z, Kuba M, Spekreijse H, Blakemore C (1995) Contrast dependence of motion-onset and pattern-reversal evoked potentials. Vision Res 35(2):197–205CrossRefPubMed

23.

Sawaya RA, Haddad RS (2002) Effect of cataract on pattern reversal visual evoked potential. Ann Ophthalmol 34(4):190–193. doi:10.1007/s12009-002-0074-9 CrossRef

24.

Ermers HJM, De Heer LJ, Van Lith GHM (1974) VECPS in patients with glaucoma. In: Dodt E, Pearlman J (eds) XIth I.S.C.E.R.G. Symposium, vol 4. Documenta Ophthalmologica Proceedings Series. Springer, Netherlands, pp 387–393. doi:10.1007/978-94-010-2340-5_45

25.

Wildberger HG, Van Lith GH, Wijngaarde R, Mak GT (1976) Visually evoked cortical potentials in the evaluation of homonymous and bitemporal visual field defects. Br J Ophthalmol 60(4):273–278PubMedCentralCrossRefPubMed

26.

Bartl G (1978) The electroretinogram and the visual evoked potential in normal and glaucomatous eyes (author’s transl). Graefes Arch Clin Exp Ophthalmol 207(4):243–269CrossRef

27.

Korth M, Nguyen NX, Junemann A, Martus P, Jonas JB (1994) VEP test of the blue-sensitive pathway in glaucoma. Invest Ophthalmol Vis Sci 35(5):2599–2610PubMed

28.

Adams AJ, Rodic R, Husted R, Stamper R (1982) Spectral sensitivity and color discrimination changes in glaucoma and glaucoma-suspect patients. Invest Ophthalmol Vis Sci 23(4):516–524PubMed

29.

Horn FK, Michelson G, Schnitzler E, Mardin CY, Korth M, Junemann AG (2006) Visual evoked potentials of the blue-sensitive pathway under cold provocation in normals and glaucomas. J Glaucoma 15(1):17–22CrossRefPubMed

30.

Rabin J, Switkes E, Crognale M, Schneck ME, Adams AJ (1994) Visual evoked potentials in three-dimensional color space: correlates of spatio-chromatic processing. Vis Res 34(20):2657–2671CrossRefPubMed

31.

Bron AJ, Vrensen GF, Koretz J, Maraini G, Harding JJ (2000) The ageing lens. Ophthalmologica 214(1):86–104CrossRefPubMed

32.

Anstis SM, Cavanagh P (1983) A minimum motion technique for judging equiluminance. In: Sharpe JDMLT (ed) Colour vision: psychophysics and physiology. Academic, London, pp 66–77

33.

Berninger TA, Arden GB, Hogg CR, Frumkes T (1989) Separable evoked retinal and cortical potentials from each major visual pathway: preliminary results. Br J Ophthalmol 73(7):502–511PubMedCentralCrossRefPubMed

34.

Porciatti V, Sartucci F (1999) Normative data for onset VEPs to red-green and blue-yellow chromatic contrast. Clin Neurophysiol 110(4):772–781CrossRefPubMed

35.

Stifter E, Sacu S, Thaler A, Weghaupt H (2006) Contrast acuity in cataracts of different morphology and association to self-reported visual function. Invest Ophthalmol Vis Sci 47(12):5412–5422. doi:10.1167/iovs.05-1564 CrossRefPubMed

36.

Hess R, Woo G (1978) Vision through cataracts. Invest Ophthalmol Vis Sci 17(5):428–435PubMed

Title: Blue–yellow and standard pattern visual evoked potentials in phakic and pseudophakic glaucoma patients and controls
Authors: Matthias Fuest
Jule Kieckhoefel
Babac Mazinani
David Kuerten
Antonis Koutsonas
Eva Koch
Peter Walter
Niklas Plange
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-015-3152-6

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Springer Medicine

Blue–yellow and standard pattern visual evoked potentials in phakic and pseudophakic glaucoma patients and controls

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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