Skip to main content
Top
Published in: American Journal of Clinical Dermatology 1/2006

01-02-2006 | Review Article

Blood Vessel Changes during Pregnancy

A Review

Authors: Frédérique Henry, Pascale Quatresooz, Jenny C. Valverde-Lopez, Prof. Gérald E. Piérard

Published in: American Journal of Clinical Dermatology | Issue 1/2006

Login to get access

Abstract

The profound endocrine upheaval of pregnancy is frequently associated with changes in the function and structure of the blood and lymph microvasculature of the skin and mucosae. Palmar erythema is frequent but rarely severe and is associated with burning sensations. Spider telangiectasias develop in the majority of pregnant White women but are less often identified in women with darker skin. Hemangiomas and glomus tumors occur in one-third of women. A firm edema may develop on the face and extremities in the final months of pregnancy. Venous hypertension and varicosities of the lower limbs are common. Gingivitis, gum hypertrophy, and pyogenic granuloma are common in the oral cavity. The vaginal mucosa is also affected, showing a violaceous aspect, at times accompanied by varicosities of the vulva. Many gestational vascular changes regress spontaneously in the postpartum phase. Some vascular tumors may need to be treated with a vascular laser or intense pulsed light.
Footnotes
1
The use of trade names is for product identification purposes only and does not imply endorsement.
 
Literature
1.
go back to reference Callen JP. Pregnancy’s effects on the skin: common and uncommon changes. Postgrad Med J. 1984; 75: 138–45 Callen JP. Pregnancy’s effects on the skin: common and uncommon changes. Postgrad Med J. 1984; 75: 138–45
2.
3.
go back to reference Wong RC, Ellis CN. Physiologic skin changes in pregnancy. Semin Dermatol. 1989; 8: 7–11PubMed Wong RC, Ellis CN. Physiologic skin changes in pregnancy. Semin Dermatol. 1989; 8: 7–11PubMed
4.
go back to reference Martin AG, Leal-Khouri S. Physiologic skin changes associated with pregnancy. Int J Dermatol. 1992; 31: 375–8PubMedCrossRef Martin AG, Leal-Khouri S. Physiologic skin changes associated with pregnancy. Int J Dermatol. 1992; 31: 375–8PubMedCrossRef
5.
go back to reference Estève E, Saudeau L, Pierre F, et al. Physiological cutaneous signs in normal pregnancy: a study of 60 pregnant women [in French]. Ann Dermatol Venereol. 1994; 121: 227–31PubMed Estève E, Saudeau L, Pierre F, et al. Physiological cutaneous signs in normal pregnancy: a study of 60 pregnant women [in French]. Ann Dermatol Venereol. 1994; 121: 227–31PubMed
6.
go back to reference Piérard-Franchimont C, Hermanns-Lê T, Piérard GE. Skin during pregnancy [in French]. Rev Med Liege. 1999; 54: 393–400PubMed Piérard-Franchimont C, Hermanns-Lê T, Piérard GE. Skin during pregnancy [in French]. Rev Med Liege. 1999; 54: 393–400PubMed
7.
go back to reference Chang S, Agredano Z, Kimball B. Risk factors associated with striae gravidarum. J Am Acad Dermatol. 2004; 51: 881–5PubMedCrossRef Chang S, Agredano Z, Kimball B. Risk factors associated with striae gravidarum. J Am Acad Dermatol. 2004; 51: 881–5PubMedCrossRef
8.
go back to reference Hermanns JF, Piérard GE. High resolution epiluminescence colorimetry of striae distensae. J Fur Acad Dermatol Venereol. In press Hermanns JF, Piérard GE. High resolution epiluminescence colorimetry of striae distensae. J Fur Acad Dermatol Venereol. In press
9.
go back to reference Henry F, Rakic L, Van Cromphaut I, et al. Skin microcirculation, adhesion molecules and inflammatory dermatoses [in French]. Rev Med Liege. 1998; 53: 479–82PubMed Henry F, Rakic L, Van Cromphaut I, et al. Skin microcirculation, adhesion molecules and inflammatory dermatoses [in French]. Rev Med Liege. 1998; 53: 479–82PubMed
10.
go back to reference Berardesca E, Lévêque JL, Masson P. EEMCO guidance for the measurement of skin microcirculation. Skin Pharmacol Appl Skin Physiol. 2002; 15: 442–56PubMedCrossRef Berardesca E, Lévêque JL, Masson P. EEMCO guidance for the measurement of skin microcirculation. Skin Pharmacol Appl Skin Physiol. 2002; 15: 442–56PubMedCrossRef
11.
go back to reference Piérard GE. EEMCO guidance to the assessment of skin colour. J Fur Acad Dermatol Venereol. 1999; 10: 1–11 Piérard GE. EEMCO guidance to the assessment of skin colour. J Fur Acad Dermatol Venereol. 1999; 10: 1–11
12.
go back to reference Glawanakowa W, Popowa G. Studies on the desquamation of vascular endothelium in EPH-gestosis [in German]. Cor Vasa. 1988; 30: 140–5PubMed Glawanakowa W, Popowa G. Studies on the desquamation of vascular endothelium in EPH-gestosis [in German]. Cor Vasa. 1988; 30: 140–5PubMed
13.
go back to reference Sochorova R, Svecova D, Sinka L, et al. Increased endothelemia as an indirect marker of changes in the blood vessel endothelium in psoriasis. J Fur Acad Dermatol Venereol. 2004; 18: 556–9CrossRef Sochorova R, Svecova D, Sinka L, et al. Increased endothelemia as an indirect marker of changes in the blood vessel endothelium in psoriasis. J Fur Acad Dermatol Venereol. 2004; 18: 556–9CrossRef
14.
go back to reference Piérard GE, Piérard-Franchimont C, Lapière CM. Proliferation and hyperplasia of vascular endothelium in human skin. Am J Dermatopathol. 1985; 7: 477–88PubMedCrossRef Piérard GE, Piérard-Franchimont C, Lapière CM. Proliferation and hyperplasia of vascular endothelium in human skin. Am J Dermatopathol. 1985; 7: 477–88PubMedCrossRef
15.
go back to reference Piérard GE, Piérard-Franchimont C. Stochastic relationship between the growth fraction and vascularity of thin malignant melanomas. Fur J Cancer. 1997; 33: 1888–92 Piérard GE, Piérard-Franchimont C. Stochastic relationship between the growth fraction and vascularity of thin malignant melanomas. Fur J Cancer. 1997; 33: 1888–92
16.
go back to reference Heymans O, Blacher S, Brouers F, et al. Fractal quantification of the microvasculalure heterogeneity in cutaneous melanoma. Dermatology. 1999; 198: 212–7PubMedCrossRef Heymans O, Blacher S, Brouers F, et al. Fractal quantification of the microvasculalure heterogeneity in cutaneous melanoma. Dermatology. 1999; 198: 212–7PubMedCrossRef
17.
go back to reference Uhoda I, Piérard GE, Piérard-Franchimont C, et al. Vascularity and fractal dimensions of the dermo-epidermal interface in guttate and plaque type psoriasis. Dermatology. 2005; 210: 189–93PubMedCrossRef Uhoda I, Piérard GE, Piérard-Franchimont C, et al. Vascularity and fractal dimensions of the dermo-epidermal interface in guttate and plaque type psoriasis. Dermatology. 2005; 210: 189–93PubMedCrossRef
18.
go back to reference Piérard GE. Isolation of the vascular plexuses from the dermis. Am J Dermatopathol. 1985; 7: 85–6PubMedCrossRef Piérard GE. Isolation of the vascular plexuses from the dermis. Am J Dermatopathol. 1985; 7: 85–6PubMedCrossRef
19.
go back to reference Robinson JL, Hall CS, Sedzimir CB. Arteriovenous malformations, aneurysms and pregnancy. J Neurosurg. 1974; 41: 63–70PubMedCrossRef Robinson JL, Hall CS, Sedzimir CB. Arteriovenous malformations, aneurysms and pregnancy. J Neurosurg. 1974; 41: 63–70PubMedCrossRef
20.
go back to reference Banerij S, Ni J, Wang SX, et al. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyalmonan. J Cell Biol. 1999; 144: 789–801CrossRef Banerij S, Ni J, Wang SX, et al. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyalmonan. J Cell Biol. 1999; 144: 789–801CrossRef
21.
go back to reference Quatresooz P, Martalo O, Pi ’erard GE. Differential expression of al (IV) and a5 (IV) collagen chains in basal cell carcinoma. J Cutan Pathol. 2003; 30: 548–52PubMedCrossRef Quatresooz P, Martalo O, Pi ’erard GE. Differential expression of al (IV) and a5 (IV) collagen chains in basal cell carcinoma. J Cutan Pathol. 2003; 30: 548–52PubMedCrossRef
22.
go back to reference Quatresooz P, Piérard GE. Distinct expression patterns of al (IV) and a5 (IV) collagen chains in cylindroma and malignant cylindroma. Int J Mol Med. 2005; 15: 7–31 Quatresooz P, Piérard GE. Distinct expression patterns of al (IV) and a5 (IV) collagen chains in cylindroma and malignant cylindroma. Int J Mol Med. 2005; 15: 7–31
23.
go back to reference Quatresooz P, Fumal I, Willemaers V, et al. Diffuse dermal angiomatosis: undescribed pattern of immunoglobulin and complement deposits in two cases. Am J Dermatopathol. In press Quatresooz P, Fumal I, Willemaers V, et al. Diffuse dermal angiomatosis: undescribed pattern of immunoglobulin and complement deposits in two cases. Am J Dermatopathol. In press
24.
go back to reference Quatresooz P, Piérard GE. Immunohistochemical investigation of al (IV) and a5 (IV) collagen chains in a broad spectrum of melanocytic tumours. Melanoma Res. 2005; 15: 161–8PubMedCrossRef Quatresooz P, Piérard GE. Immunohistochemical investigation of al (IV) and a5 (IV) collagen chains in a broad spectrum of melanocytic tumours. Melanoma Res. 2005; 15: 161–8PubMedCrossRef
25.
go back to reference Al Buainian H, Verhaeghe E, Dierckxsens L, et al. Early treatment of hemangiomas with lasers: a review. Dermatology. 2003; 206: 370–3PubMedCrossRef Al Buainian H, Verhaeghe E, Dierckxsens L, et al. Early treatment of hemangiomas with lasers: a review. Dermatology. 2003; 206: 370–3PubMedCrossRef
26.
go back to reference Wlotzke U, Hohenleutner U, Abd-el-Raheem TA, et al. Side effects and complications of flashlamp-pumped pulsed dye later therapy of port-wine stains: a prospective study. Br J Dermatol. 1991; 24: 467–72 Wlotzke U, Hohenleutner U, Abd-el-Raheem TA, et al. Side effects and complications of flashlamp-pumped pulsed dye later therapy of port-wine stains: a prospective study. Br J Dermatol. 1991; 24: 467–72
27.
go back to reference Levine VL, Geronemus RG. Adverse effects associated with the 577 nm and 585 nm pulsed dye laser in the treatment of cutaneous vascular lesions: a study of 500 patients. J Am Acad Dermatol. 1995; 32: 613–7PubMedCrossRef Levine VL, Geronemus RG. Adverse effects associated with the 577 nm and 585 nm pulsed dye laser in the treatment of cutaneous vascular lesions: a study of 500 patients. J Am Acad Dermatol. 1995; 32: 613–7PubMedCrossRef
28.
go back to reference Raulin C, Weiss RA, Schonermark MP. Treatment of essential telangiectasias with an intense pulsed light source (Photoderm VL). Dermatol Surg. 1997; 23: 941–5PubMedCrossRef Raulin C, Weiss RA, Schonermark MP. Treatment of essential telangiectasias with an intense pulsed light source (Photoderm VL). Dermatol Surg. 1997; 23: 941–5PubMedCrossRef
29.
go back to reference Schroeter CA, Neumann HA. An intense light source: the photoderm VL-flashlamp as a new treatment possibility for vascular skin lesions. Dermatol Surg. 1998; 24: 74–8CrossRef Schroeter CA, Neumann HA. An intense light source: the photoderm VL-flashlamp as a new treatment possibility for vascular skin lesions. Dermatol Surg. 1998; 24: 74–8CrossRef
30.
go back to reference Angermeier MC. Treatment of facial vascular lesions with intense pulsed light. J Cutan Laser Ther. 1999; 1: 95–100PubMed Angermeier MC. Treatment of facial vascular lesions with intense pulsed light. J Cutan Laser Ther. 1999; 1: 95–100PubMed
31.
go back to reference Green D. Photothermal removal of telangiectasias of the lower extremities with the Photoderm VL. J Am Acad Dermatol. 1998; 38: 61–8PubMedCrossRef Green D. Photothermal removal of telangiectasias of the lower extremities with the Photoderm VL. J Am Acad Dermatol. 1998; 38: 61–8PubMedCrossRef
32.
go back to reference Retamar RA, Chames C, Pellerano G. Treatment of linear and spider telangiectasia with an intense pulsed light source. J Cosmet Dermatol. 2004; 3: 187–90PubMedCrossRef Retamar RA, Chames C, Pellerano G. Treatment of linear and spider telangiectasia with an intense pulsed light source. J Cosmet Dermatol. 2004; 3: 187–90PubMedCrossRef
33.
go back to reference Poetke M, Philipp C, Berlien HP. Flashlamp pumped pulsed dye laser for hemangiomas in infancy: treatment of superficial vs mixed hemangiomas. Arch Dermatol. 2000; 136: 628–32PubMedCrossRef Poetke M, Philipp C, Berlien HP. Flashlamp pumped pulsed dye laser for hemangiomas in infancy: treatment of superficial vs mixed hemangiomas. Arch Dermatol. 2000; 136: 628–32PubMedCrossRef
34.
go back to reference Raulin C, Greve B. Retrospective clinical comparison of hemangioma treatment by Fashlamp pumped (585 nm) and frequency-doubled Nd:YAG (532 nm) lasers. Lasers Surg Med. 2001; 28: 40–3PubMedCrossRef Raulin C, Greve B. Retrospective clinical comparison of hemangioma treatment by Fashlamp pumped (585 nm) and frequency-doubled Nd:YAG (532 nm) lasers. Lasers Surg Med. 2001; 28: 40–3PubMedCrossRef
35.
go back to reference Goldman MP. Treatment of benign vascular lesions with a Photoderm VL high-intensity pulsed source. Adv Dermatol. 1997; 13: 503–21PubMed Goldman MP. Treatment of benign vascular lesions with a Photoderm VL high-intensity pulsed source. Adv Dermatol. 1997; 13: 503–21PubMed
36.
go back to reference Raulin C, Schroeter CA, Weiss R, et al. Treatment of port-wine stains with a noncoherent light source: a retrospective study. Arch Dermatol. 1999; 135: 679–83PubMedCrossRef Raulin C, Schroeter CA, Weiss R, et al. Treatment of port-wine stains with a noncoherent light source: a retrospective study. Arch Dermatol. 1999; 135: 679–83PubMedCrossRef
Metadata
Title
Blood Vessel Changes during Pregnancy
A Review
Authors
Frédérique Henry
Pascale Quatresooz
Jenny C. Valverde-Lopez
Prof. Gérald E. Piérard
Publication date
01-02-2006
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 1/2006
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.2165/00128071-200607010-00006

Other articles of this Issue 1/2006

American Journal of Clinical Dermatology 1/2006 Go to the issue