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Neurocritical Care
Published in: Neurocritical Care 2/2015

01-10-2015 | Original Article

Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage

Authors: Rickard L. Sjöberg, Tommy Bergenheim, Lina Mörén, Henrik Antti, Cecilia Lindgren, Silvana Naredi, Peter Lindvall

Published in: Neurocritical Care | Issue 2/2015

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Abstract

Background

Delayed neurological deficit (DND) is the most important cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) whose aneurysms have been secured. However, the methods currently used to predict the development of DND, such as trans-cranial Doppler or levels biochemical markers in blood and cerebrospinal fluid are not very accurate.

Method

Venous blood was drawn from 50 patients with SAH, admitted to the neurosurgical department Umeå University Hospital, at day 1–3 and day 7 after the bleed. The clinical status of the patients was followed up approximately 1 year after this episode and classified according to the Glasgow Outcome Score (GOS).

Results

Results showed considerable differences in blood metabolomic patterns between day 1–3 and 7 after the hemorrhage. Fifty-six out of 98 metabolites could be identified from our in-house library and 17 of these metabolites changed significantly from day 1–3 to 7 after the bleed. One of these, myo-inositol, was predictive of clinical outcome even after correction for multiple testing. An estimation of the diagnostic accuracy of high levels of this substance in predicting good outcome (GOS 4–5) yielded a sensitivity of .763 and a specificity of .5 at the optimal cut off point.

Conclusions

SAH is an event with a profound effect on blood metabolomics profiles. Myo-inositol might be an interesting compound for future study to focus on in the search for metabolic markers in venous blood of delayed neurological deterioration in SAH patients.
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Metadata
Title
Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage
Authors
Rickard L. Sjöberg
Tommy Bergenheim
Lina Mörén
Henrik Antti
Cecilia Lindgren
Silvana Naredi
Peter Lindvall
Publication date
01-10-2015
Publisher
Springer US
Published in
Neurocritical Care / Issue 2/2015
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-014-0089-2

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