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01-02-2018 | ORIGINAL ARTICLE

Blood Glutamate Reducing Effect of Hemofiltration in Critically Ill Patients

Authors: Evgeni Brotfain, Ruslan Kutz, Julia Grinshpun, Benjamin F. Gruenbaum, Shaun E. Gruenbaum, Amit Frenkel, Agzam Zhumadilov, Vladimir Zeldetz, Yoav Bichovsky, Matthew Boyko, Moti Klein, Alexander Zlotnik

Published in: Neurotoxicity Research | Issue 2/2018

Abstract

Glutamate toxicity plays a well-established role in secondary brain damage following acute and chronic brain insults. Previous studies have demonstrated the efficacy of hemodialysis and peritoneal dialysis in reducing blood glutamate levels. However, these methods are not viable options for hemodynamically unstable patients. Given more favorable hemodynamics, longer treatment, and less needed anticoagulation, we investigated whether hemofiltration could be effective in lowering blood glutamate levels. Blood samples were taken from 10 critically ill patients immediately before initiation of hemofiltration and after 1, 2, 4, 6, and 12 h, for a total of 6 blood samples. Samples were sent for determination of glutamate, glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), hemoglobin, hematocrit, urea, creatinine, glucose, sodium, potassium, platelet, and white blood cell (WBC) levels. There was a statistically significant reduction in blood glutamate levels at all time points compared to baseline levels. There was no difference in levels of GOT or GPT. Hemofiltration can be a promising method of reducing blood glutamate levels, especially in critically ill patients where hemodialysis and peritoneal dialysis may be contraindicated.

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Title: Blood Glutamate Reducing Effect of Hemofiltration in Critically Ill Patients
Authors: Evgeni Brotfain
Ruslan Kutz
Julia Grinshpun
Benjamin F. Gruenbaum
Shaun E. Gruenbaum
Amit Frenkel
Agzam Zhumadilov
Vladimir Zeldetz
Yoav Bichovsky
Matthew Boyko
Moti Klein
Alexander Zlotnik
Publication date: 01-02-2018
Publisher: Springer US
Published in: Neurotoxicity Research / Issue 2/2018
Print ISSN: 1029-8428
Electronic ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-017-9791-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Blood Glutamate Reducing Effect of Hemofiltration in Critically Ill Patients

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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