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01-01-2011 | Editorial

Blood–CNS barrier, neurodegeneration and neuroprotection: recent therapeutic advancements and nano-drug delivery

Author: Hari S. Sharma

Published in: Journal of Neural Transmission | Issue 1/2011

Excerpt

Recent advancement on new therapies to induce neuroprotection in central nervous system (CNS) following injury or neuroregeneration necessitates reviewing the current state of the art in the field. This volume is a refereed collection of selected reviews and original research articles written by the leading experts in the field of neurodegeneration and neuroregeneration. The authors highlight new avenues for neuroprotection and/or neurorepair in different CNS injury models based on their own work and in the light of recent findings in the literature. …

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Johanson CE, Stopa EG, McMillan PN (2011) The blood-cerebrospinal fluid barrier: structure and functional significance. Methods Mol Biol 686:101–131PubMedCrossRef

Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, Powers K, Shen H, Egan JM, Sambamurti K, Brossi A, Lahiri DK, Mattson MP, Hoffer BJ, Wang Y, Greig NH (2009) GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci USA 106(4):1285–1290PubMedCrossRef

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Miclescu A, Sharma HS, Martijn C, Wiklund L (2010) Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions. Crit Care Med 38(11):2199–2206PubMedCrossRef

Oxenkrug GF (2010) Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later. Isr J Psychiatry Relat Sci 47(1):56–63PubMed

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Sharma HS (2005) Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr Pharm Des 11(11):1353–1389 (review)PubMedCrossRef

Sharma HS (2007) Neurotrophic factors in combination: a possible new therapeutic strategy to influence pathophysiology of spinal cord injury and repair mechanisms. Curr Pharm Des 13(18):1841–1874 (review)PubMedCrossRef

Sharma HS (2008) New perspectives for the treatment options in spinal cord injury. Expert Opin Pharmacother 9(16):2773–2800 (review)PubMedCrossRef

Sharma HS (2009) Blood–central nervous system barriers: the gateway to neurodegeneration, neuroprotection and neuroregeneration. In: Lajtha A, Banik N, Ray SK (eds) Handbook of neurochemistry and molecular neurobiology: brain and spinal cord trauma. Springer, Berlin, pp 363–457

Sharma HS, Johanson CE (2007) Intracerebroventricularly administered neurotrophins attenuate blood cerebrospinal fluid barrier breakdown and brain pathology following whole-body hyperthermia: an experimental study in the rat using biochemical and morphological approaches. Ann N Y Acad Sci 1122:112–129PubMedCrossRef

Sharma HS, Kiyatkin EA (2009) Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: an experimental study using light and electron microscopy. J Chem Neuroanat 37(1):18–32

Sharma HS, Sharma A (2010) Breakdown of the blood-brain barrier in stress alters cognitive dysfunction and induces brain pathology. New perspective for neuroprotective strategies. In: Ritsner M (ed) Brain protection in schizophrenia, mood and cognitive disorders. Springer, Berlin, pp 243–304

Sharma HS, Westman J (2004) The blood-spinal cord and brain barriers in health and disease. Academic Press, San Diego, pp 1–617

Sharma HS, Ali SF, Dong W, Tian ZR, Patnaik R, Patnaik S, Sharma A, Boman A, Lek P, Seifert E, Lundstedt T (2007a) Drug delivery to the spinal cord tagged with nanowire enhances neuroprotective efficacy and functional recovery following trauma to the rat spinal cord. Ann N Y Acad Sci 1122:197–218PubMedCrossRef

Sharma HS, Sjöquist PO, Ali SF (2007b) Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51. Curr Pharm Des 13(18):1903–1923PubMedCrossRef

Sharma HS, Ali S, Tian ZR, Patnaik R, Patnaik S, Lek P, Sharma A, Lundstedt T (2009) Nano-drug delivery and neuroprotection in spinal cord injury. J Nanosci Nanotechnol 9(8):5014–5037PubMedCrossRef

Westerlund M, Hoffer B, Olson L (2010) Parkinson’s disease: exit toxins, enter genetics. Prog Neurobiol 90(2):146–156 (review)

Title: Blood–CNS barrier, neurodegeneration and neuroprotection: recent therapeutic advancements and nano-drug delivery
Author: Hari S. Sharma
Publication date: 01-01-2011
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 1/2011
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-010-0542-0

At a glance: The STEP trials

Springer Medicine

Blood–CNS barrier, neurodegeneration and neuroprotection: recent therapeutic advancements and nano-drug delivery

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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