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Journal of Anesthesia

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01-04-2011 | Original Article

Blockade of 5-HT_2A and/or 5-HT_2C receptors modulates sevoflurane-induced immobility

Authors: Hirokazu Nagatani, Tsutomu Oshima, Akiyoshi Urano, Yuhji Saitoh, Miyuki Yokota, Yoshinori Nakata

Published in: Journal of Anesthesia | Issue 2/2011

Abstract

Purpose

Blockade of 5-hydroxytryptamine (5-HT)_2A receptors reportedly mediates or modulates the ability of isoflurane to produce immobility during noxious stimulation and would thereby influence MAC (the minimum alveolar concentration required to suppress movement in response to noxious stimulation in 50% of subjects). However, no data are yet available regarding the role of this receptor in the immobilizing action of sevoflurane. In this study, we examined how prior intraperitoneal administration of either the 5-HT_2A receptor antagonist altanserin or the 5-HT_2C/2B receptor antagonist SB 206553 might affect sevoflurane MAC in rats.

Methods

Three groups of six male Wistar rats weighing 250–350 g each received one of the following drugs dissolved in dimethyl sulfoxide intraperitoneally 30 min before MAC testing: (1) altanserin 10 mg/kg; (2) SB 206553 10 mg/kg; (3) no drug (vehicle control). MAC was defined as the average of the concentrations that just prevented or just permitted movement in response to clamping the tail for 1 min.

Results

The rank order of MAC values obtained after intraperitoneal drug pretreatment and sevoflurane exposure was altanserin < SB 206553 < vehicle control.

Conclusion

Considering the low levels of 5-HT_2B receptors within the CNS, this result suggests that 5-HT_2A and the 5-HT_2C receptors are present within the neural circuitry influencing sevoflurane MAC. Blockade of 5-HT_2A and/or 5-HT_2C receptors may modulate the immobility produced by sevoflurane during noxious stimulation.

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Title: Blockade of 5-HT2A and/or 5-HT2C receptors modulates sevoflurane-induced immobility
Authors: Hirokazu Nagatani
Tsutomu Oshima
Akiyoshi Urano
Yuhji Saitoh
Miyuki Yokota
Yoshinori Nakata
Publication date: 01-04-2011
Publisher: Springer Japan
Published in: Journal of Anesthesia / Issue 2/2011
Print ISSN: 0913-8668
Electronic ISSN: 1438-8359
DOI: https://doi.org/10.1007/s00540-011-1103-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Blockade of 5-HT_2A and/or 5-HT_2C receptors modulates sevoflurane-induced immobility

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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