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Published in: Clinical Oral Investigations 1/2020

01-01-2020 | Bleaching | Original Article

Bleaching-induced tooth sensitivity with application of a desensitizing gel before and after in-office bleaching: a triple-blind randomized clinical trial

Authors: E. C. Martini, S. O. Parreiras, A. L. Szesz, F. M. Coppla, A. D. Loguercio, Alessandra Reis

Published in: Clinical Oral Investigations | Issue 1/2020

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Abstract

Objectives

This randomized triple-blind clinical trial, split-mouth design, evaluated the application effect of the desensitizing gel before and after in-office bleaching on tooth sensitivity.

Materials and methods

In one group, the desensitizing gel was applied for 10 min before the bleaching with 35% hydrogen peroxide, and then application of placebo gel after (n = 90). In the other group, the desensitizing gel was applied before and after the bleaching procedure for 10 min (n = 90). The primary outcome was pain intensity assessed with a numeric rating scale and a visual analog scale. Color was evaluated by means of a digital spectrophotometer and a shade guides.

Results

The proportion of patients that experienced pain in the side of before application was 90% (95% CI 82 to 94.6%), while the side of before and after was 93% (95% CI 86.2 to 96.9%), without significant difference between groups (OR = 0.25; 95% CI 0.005 to 2.52; p = 0.37). Pain was correlated in both groups, for the NRS scale (p < 0.0001) and the VAS scale (p < 0.0001) in all assessment periods. Significant whitening was detected, and no significant difference of color change was observed between groups (p > 0.45).

Conclusions

The application of the desensitizing agent did not influence the effectiveness of bleaching, but it was not efficient in reducing the sensitivity, when applied before the procedure, or before and after.

Clinical relevance

The use of a desensitizing gel before or after in-office bleaching does not reduce incidence or intensity of tooth sensitivity.
Literature
3.
go back to reference Perdigao J (2010) Dental whitening—revisiting the myths. Northwest Dent 89(6):19–21 23–16PubMed Perdigao J (2010) Dental whitening—revisiting the myths. Northwest Dent 89(6):19–21 23–16PubMed
5.
go back to reference Tay LY, Kose C, Herrera DR, Reis A, Loguercio AD (2012) Long-term efficacy of in-office and at-home bleaching: a 2-year double-blind randomized clinical trial. Am J Dent 25(4):199–204PubMed Tay LY, Kose C, Herrera DR, Reis A, Loguercio AD (2012) Long-term efficacy of in-office and at-home bleaching: a 2-year double-blind randomized clinical trial. Am J Dent 25(4):199–204PubMed
6.
go back to reference Basting RT, Amaral FL, Franca FM, Florio FM (2012) Clinical comparative study of the effectiveness of and tooth sensitivity to 10% and 20% carbamide peroxide home-use and 35% and 38% hydrogen peroxide in-office bleaching materials containing desensitizing agents. Oper Dent 37(5):464–473. https://doi.org/10.2341/11-337-c CrossRefPubMed Basting RT, Amaral FL, Franca FM, Florio FM (2012) Clinical comparative study of the effectiveness of and tooth sensitivity to 10% and 20% carbamide peroxide home-use and 35% and 38% hydrogen peroxide in-office bleaching materials containing desensitizing agents. Oper Dent 37(5):464–473. https://​doi.​org/​10.​2341/​11-337-c CrossRefPubMed
8.
go back to reference Alomari Q, El Daraa E (2010) A randomized clinical trial of in-office dental bleaching with or without light activation. J Contemp Dent Pract 11(1):E017–E024CrossRef Alomari Q, El Daraa E (2010) A randomized clinical trial of in-office dental bleaching with or without light activation. J Contemp Dent Pract 11(1):E017–E024CrossRef
11.
go back to reference Tay LY, Kose C, Loguercio AD, Reis A (2009) Assessing the effect of a desensitizing agent used before in-office tooth bleaching. J Am Dent Assoc (1939) 140(10):1245–1251CrossRef Tay LY, Kose C, Loguercio AD, Reis A (2009) Assessing the effect of a desensitizing agent used before in-office tooth bleaching. J Am Dent Assoc (1939) 140(10):1245–1251CrossRef
13.
go back to reference Magloire H, Maurin JC, Couble ML, Shibukawa Y, Tsumura M, Thivichon-Prince B, Bleicher F (2010) Topical review. Dental pain and odontoblasts: facts and hypotheses. J Orofac Pain 24(4):335–349PubMed Magloire H, Maurin JC, Couble ML, Shibukawa Y, Tsumura M, Thivichon-Prince B, Bleicher F (2010) Topical review. Dental pain and odontoblasts: facts and hypotheses. J Orofac Pain 24(4):335–349PubMed
15.
go back to reference Coppla FM, Rezende M, de Paula E, Farago PV, Loguercio AD, Kossatz S, Reis A (2018) Combination of acetaminophen/codeine analgesics does not avoid bleaching-induced tooth sensitivity: a randomized, triple-blind two-center clinical trial. Oper Dent 43(2):E53–E63. https://doi.org/10.2341/17-092-c CrossRefPubMed Coppla FM, Rezende M, de Paula E, Farago PV, Loguercio AD, Kossatz S, Reis A (2018) Combination of acetaminophen/codeine analgesics does not avoid bleaching-induced tooth sensitivity: a randomized, triple-blind two-center clinical trial. Oper Dent 43(2):E53–E63. https://​doi.​org/​10.​2341/​17-092-c CrossRefPubMed
22.
go back to reference da Costa Poubel LA, de Gouvea CVD, Calazans FS, Dip EC, Alves WV, Marins SS, Barcelos R, Barceleiro MO (2018) Pre-operative use of dexamethasone does not reduce incidence or intensity of bleaching-induced tooth sensitivity. A triple-blind, parallel-design, randomized clinical trial. Clin Oral Investig 23:435–444. https://doi.org/10.1007/s00784-018-2452-8 CrossRefPubMed da Costa Poubel LA, de Gouvea CVD, Calazans FS, Dip EC, Alves WV, Marins SS, Barcelos R, Barceleiro MO (2018) Pre-operative use of dexamethasone does not reduce incidence or intensity of bleaching-induced tooth sensitivity. A triple-blind, parallel-design, randomized clinical trial. Clin Oral Investig 23:435–444. https://​doi.​org/​10.​1007/​s00784-018-2452-8 CrossRefPubMed
27.
go back to reference Orchardson R, Gillam DG (2000) The efficacy of potassium salts as agents for treating dentin hypersensitivity. J Orofac Pain 14(1):9–19PubMed Orchardson R, Gillam DG (2000) The efficacy of potassium salts as agents for treating dentin hypersensitivity. J Orofac Pain 14(1):9–19PubMed
28.
go back to reference Haywood VB, Caughman WF, Frazier KB, Myers ML (2001) Tray delivery of potassium nitrate-fluoride to reduce bleaching sensitivity. Quintessence Int 32(2):105–109PubMed Haywood VB, Caughman WF, Frazier KB, Myers ML (2001) Tray delivery of potassium nitrate-fluoride to reduce bleaching sensitivity. Quintessence Int 32(2):105–109PubMed
31.
go back to reference Tam L (2001) Effect of potassium nitrate and fluoride on carbamide peroxide bleaching. Quintessence Int 32(10):766–770PubMed Tam L (2001) Effect of potassium nitrate and fluoride on carbamide peroxide bleaching. Quintessence Int 32(10):766–770PubMed
36.
go back to reference Cook SP, McCleskey EW (2002) Cell damage excites nociceptors through release of cytosolic ATP. Pain 95(1–2):41–47CrossRef Cook SP, McCleskey EW (2002) Cell damage excites nociceptors through release of cytosolic ATP. Pain 95(1–2):41–47CrossRef
38.
go back to reference Bartold PM (2006) Dentinal hypersensitivity: a review. Aust Dent J 51(3):212–218 quiz 276CrossRef Bartold PM (2006) Dentinal hypersensitivity: a review. Aust Dent J 51(3):212–218 quiz 276CrossRef
39.
go back to reference Hodosh M (1974) A superior desensitizer—potassium nitrate. J Am Dent Assoc (1939) 88(4):831–832CrossRef Hodosh M (1974) A superior desensitizer—potassium nitrate. J Am Dent Assoc (1939) 88(4):831–832CrossRef
40.
go back to reference Leonard RH Jr, Smith LR, Garland GE, Caplan DJ (2004) Desensitizing agent efficacy during whitening in an at-risk population. J Esthet Restor Dent 16(1):49–55 discussion 56CrossRef Leonard RH Jr, Smith LR, Garland GE, Caplan DJ (2004) Desensitizing agent efficacy during whitening in an at-risk population. J Esthet Restor Dent 16(1):49–55 discussion 56CrossRef
41.
go back to reference Armenio RV, Fitarelli F, Armenio MF, Demarco FF, Reis A, Loguercio AD (2008) The effect of fluoride gel use on bleaching sensitivity: a double-blind randomized controlled clinical trial. J Am Dent Assoc (1939) 139(5):592–597 quiz 626-597CrossRef Armenio RV, Fitarelli F, Armenio MF, Demarco FF, Reis A, Loguercio AD (2008) The effect of fluoride gel use on bleaching sensitivity: a double-blind randomized controlled clinical trial. J Am Dent Assoc (1939) 139(5):592–597 quiz 626-597CrossRef
44.
go back to reference Borenstein M, Hedges LV, Higgins JPT, Rothstein HR (2011) Introduction to meta-analysis. Wiley Borenstein M, Hedges LV, Higgins JPT, Rothstein HR (2011) Introduction to meta-analysis. Wiley
Metadata
Title
Bleaching-induced tooth sensitivity with application of a desensitizing gel before and after in-office bleaching: a triple-blind randomized clinical trial
Authors
E. C. Martini
S. O. Parreiras
A. L. Szesz
F. M. Coppla
A. D. Loguercio
Alessandra Reis
Publication date
01-01-2020
Publisher
Springer Berlin Heidelberg
Keywords
Bleaching
Nitrate
Published in
Clinical Oral Investigations / Issue 1/2020
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-019-02942-9

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