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Open Access 01-09-2007 | Review

BK virus infection, replication, and diseases in pediatric kidney transplantation

Authors: Philip D. Acott, Hans H. Hirsch

Published in: Pediatric Nephrology | Issue 9/2007

Abstract

Polyomavirus-associated nephropathy is diagnosed in 2–8% of pediatric renal transplants and often precedes renal allograft dysfunction. Without intervention, however, significant graft dysfunction is observed in more than 50% of cases, although progressive early graft loss is reported in only three of 32 (9%) of cases. No specific treatment is available, but early decrease in immunosuppression is followed by declining human polyomavirus type 1 (BK virus) replication and improved outcome. The data suggest differences between pediatric and adult kidney transplantation. Possibly, pediatric patients might be able to mount a more vigorous BK virus-specific immune response than adult patients under similar modulation of immunosuppression. Also the role of cidofovir and leflunomide is still unresolved in pediatric patients. Larger prospective trials are needed to better define the impact of BK virus immunity for replication and disease as well as the role of reducing immunosuppression with or without cidofovir or leflunomide in pediatric transplant patients.

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Title: BK virus infection, replication, and diseases in pediatric kidney transplantation
Authors: Philip D. Acott
Hans H. Hirsch
Publication date: 01-09-2007
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 9/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0462-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

BK virus infection, replication, and diseases in pediatric kidney transplantation

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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