Skip to main content
Top
Published in: Endocrine 2/2015

01-03-2015 | Editorial

Bisphosphonates in the treatment of HIV-related osteoporosis

Authors: Fabio Vescini, Franco Grimaldi

Published in: Endocrine | Issue 2/2015

Login to get access

Excerpt

In this number, Pepe et al. are publishing a paper evaluating the effects of 1 year of risedronate treatment on bone mineral density (BMD) in HIV-infected patients with or without hypogonadism [1]. Their results show that also, risedronate is effective in the therapeutic management of osteoporosis in HIV, as well as alendronate and zoledronate. …
Literature
1.
go back to reference J. Pepe, A.M. Isidori, M. Falciano, G. Iaiani, A. Salotti, D. Diacinti, R. Del Fiacco, E. Sbardella, C. Cipriani, S. Piemonte, O. Raimo, P. Biondi, F. Biamonte, A. Lenzi, S. Minisola, Effect of risedronate in osteoporotic HIV males, according to gonadal status: a pilot study. Endocrine (2014). doi:10.1007/s12020-014-0349-0 J. Pepe, A.M. Isidori, M. Falciano, G. Iaiani, A. Salotti, D. Diacinti, R. Del Fiacco, E. Sbardella, C. Cipriani, S. Piemonte, O. Raimo, P. Biondi, F. Biamonte, A. Lenzi, S. Minisola, Effect of risedronate in osteoporotic HIV males, according to gonadal status: a pilot study. Endocrine (2014). doi:10.​1007/​s12020-014-0349-0
2.
go back to reference M. Borderi, L. Calza, V. Colangeli, E. Vanino, P. Viale, D. Gibellini, M.C. Re, Prevalence of subclinical vertebral fractures in HIV-infected patients. New Microbiol. 37, 25–32 (2014)PubMed M. Borderi, L. Calza, V. Colangeli, E. Vanino, P. Viale, D. Gibellini, M.C. Re, Prevalence of subclinical vertebral fractures in HIV-infected patients. New Microbiol. 37, 25–32 (2014)PubMed
3.
go back to reference C. Torti, G. Mazziotti, P.A. Soldini, E. Focà, R. Maroldi, D. Gotti, G. Carosi, A. Giustina, High prevalence of radiological vertebral fractures in HIV-infected males. Endocrine 41, 512–517 (2012)CrossRefPubMed C. Torti, G. Mazziotti, P.A. Soldini, E. Focà, R. Maroldi, D. Gotti, G. Carosi, A. Giustina, High prevalence of radiological vertebral fractures in HIV-infected males. Endocrine 41, 512–517 (2012)CrossRefPubMed
4.
go back to reference J.D. Lundgren, M. Battegay, G. Behrens, S. De Wit, G. Guaraldi, C. Katlama, E. Martinez, D. Nair, W.G. Powderly, P. Reiss, J. Sutinen, A. Vigano, EACS Executive Committee, European AIDS Clinical Society (EACS) guidelines on the prevention and management of metabolic diseases in HIV. HIV Med. 9(2), 72–81 (2008)CrossRefPubMed J.D. Lundgren, M. Battegay, G. Behrens, S. De Wit, G. Guaraldi, C. Katlama, E. Martinez, D. Nair, W.G. Powderly, P. Reiss, J. Sutinen, A. Vigano, EACS Executive Committee, European AIDS Clinical Society (EACS) guidelines on the prevention and management of metabolic diseases in HIV. HIV Med. 9(2), 72–81 (2008)CrossRefPubMed
5.
go back to reference G.A. McComsey, P. Tebas, E. Shane, M.T. Yin, E.T. Overton, J.S. Huang, G.M. Aldrovandi, S.W. Cardoso, J.L. Santana, T.T. Brown, Bone disease in HIV infection: a practical review and recommendations for HIV care providers. Clin. Infect. Dis. 51(8), 937–946 (2010)CrossRefPubMedCentralPubMed G.A. McComsey, P. Tebas, E. Shane, M.T. Yin, E.T. Overton, J.S. Huang, G.M. Aldrovandi, S.W. Cardoso, J.L. Santana, T.T. Brown, Bone disease in HIV infection: a practical review and recommendations for HIV care providers. Clin. Infect. Dis. 51(8), 937–946 (2010)CrossRefPubMedCentralPubMed
6.
go back to reference G. Guaraldi, G. Orlando, G. Madeddu, F. Vescini, P. Ventura, S. Campostrini, M.S. Mura, N. Parise, R. Caudarella, R. Esposito, Alendronate reduces bone resorption in HIV-associated osteopenia/osteoporosis. HIV Clin. Trials 5(5), 269–277 (2004)CrossRefPubMed G. Guaraldi, G. Orlando, G. Madeddu, F. Vescini, P. Ventura, S. Campostrini, M.S. Mura, N. Parise, R. Caudarella, R. Esposito, Alendronate reduces bone resorption in HIV-associated osteopenia/osteoporosis. HIV Clin. Trials 5(5), 269–277 (2004)CrossRefPubMed
7.
go back to reference K. Mondy, W.G. Powderly, S.A. Claxton, K.H. Yarasheski, M. Royal, J.S. Stoneman, M.E. Hoffmann, P. Tebas, Alendronate, vitamin D, and calcium for the treatment of osteopenia/osteoporosis associated with HIV infection. J. Acquir. Immune. Defic. Syndr. 38(4), 426–431 (2005)CrossRefPubMed K. Mondy, W.G. Powderly, S.A. Claxton, K.H. Yarasheski, M. Royal, J.S. Stoneman, M.E. Hoffmann, P. Tebas, Alendronate, vitamin D, and calcium for the treatment of osteopenia/osteoporosis associated with HIV infection. J. Acquir. Immune. Defic. Syndr. 38(4), 426–431 (2005)CrossRefPubMed
8.
go back to reference G.A. McComsey, M.A. Kendall, P. Tebas, S. Swindells, E. Hogg, B. Alston-Smith, C. Suckow, G. Gopalakrishnan, C. Benson, D.A. Wohl, Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV. AIDS 21(18), 2473–2482 (2007)CrossRefPubMed G.A. McComsey, M.A. Kendall, P. Tebas, S. Swindells, E. Hogg, B. Alston-Smith, C. Suckow, G. Gopalakrishnan, C. Benson, D.A. Wohl, Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV. AIDS 21(18), 2473–2482 (2007)CrossRefPubMed
9.
go back to reference M.J. Bolland, A.B. Grey, A.M. Horne, S.E. Briggs, M.G. Thomas, R.B. Ellis-Pegler, A.F. Woodhouse, G.D. Gamble, I.R. Reid, Annual zoledronate increases bone density in highly active antiretroviral therapy-treated human immunodeficiency virus-infected men: a randomized controlled trial. J. Clin. Endocrinol. Metab. 92(4), 1283–1288 (2007)CrossRefPubMed M.J. Bolland, A.B. Grey, A.M. Horne, S.E. Briggs, M.G. Thomas, R.B. Ellis-Pegler, A.F. Woodhouse, G.D. Gamble, I.R. Reid, Annual zoledronate increases bone density in highly active antiretroviral therapy-treated human immunodeficiency virus-infected men: a randomized controlled trial. J. Clin. Endocrinol. Metab. 92(4), 1283–1288 (2007)CrossRefPubMed
10.
go back to reference M.J. Bolland, A. Grey, A.M. Horne, S.E. Briggs, M.G. Thomas, R.B. Ellis-Pegler, G.D. Gamble, I.R. Reid, Effects of intravenous zoledronate on bone turnover and bone density persist for at least five years in HIV-infected men. J. Clin. Endocrinol. Metab. 97(6), 1922–1928 (2012)CrossRefPubMed M.J. Bolland, A. Grey, A.M. Horne, S.E. Briggs, M.G. Thomas, R.B. Ellis-Pegler, G.D. Gamble, I.R. Reid, Effects of intravenous zoledronate on bone turnover and bone density persist for at least five years in HIV-infected men. J. Clin. Endocrinol. Metab. 97(6), 1922–1928 (2012)CrossRefPubMed
11.
go back to reference F. Vescini, A. Cozzi-Lepri, M. Borderi, M.C. Re, F. Maggiolo, A. De Luca, G. Cassola, V. Vullo, G. Carosi, A. Antinori, V. Tozzi, A.D. Monforte, Icona Foundation Study Group, Prevalence of hypovitaminosis D and factors associated with vitamin D deficiency and morbidity among HIV-infected patients enrolled in a large Italian cohort. J. Acquir. Immune. Defic. Syndr. 58, 163–172 (2011)CrossRefPubMed F. Vescini, A. Cozzi-Lepri, M. Borderi, M.C. Re, F. Maggiolo, A. De Luca, G. Cassola, V. Vullo, G. Carosi, A. Antinori, V. Tozzi, A.D. Monforte, Icona Foundation Study Group, Prevalence of hypovitaminosis D and factors associated with vitamin D deficiency and morbidity among HIV-infected patients enrolled in a large Italian cohort. J. Acquir. Immune. Defic. Syndr. 58, 163–172 (2011)CrossRefPubMed
12.
go back to reference S. Adami, S. Giannini, G. Bianchi, L. Sinigaglia, O. Di Munno, C.E. Fiore, S. Minisola, M. Rossini, Vitamin D status and response to treatment in post-menopausal osteoporosis. Osteoporos. Int. 20, 239–244 (2009)CrossRefPubMed S. Adami, S. Giannini, G. Bianchi, L. Sinigaglia, O. Di Munno, C.E. Fiore, S. Minisola, M. Rossini, Vitamin D status and response to treatment in post-menopausal osteoporosis. Osteoporos. Int. 20, 239–244 (2009)CrossRefPubMed
13.
go back to reference M.L. Gourlay, J.P. Fine, J.S. Preisser, R.C. May, C. Li, L.Y. Lui, D.F. Ransohoff, J.A. Cauley, K.E. Ensrud, Study of Osteoporotic Fractures Research Group, Bone-density testing interval and transition to osteoporosis in older women. N. Engl. J. Med. 366, 225–233 (2012)CrossRefPubMedCentralPubMed M.L. Gourlay, J.P. Fine, J.S. Preisser, R.C. May, C. Li, L.Y. Lui, D.F. Ransohoff, J.A. Cauley, K.E. Ensrud, Study of Osteoporotic Fractures Research Group, Bone-density testing interval and transition to osteoporosis in older women. N. Engl. J. Med. 366, 225–233 (2012)CrossRefPubMedCentralPubMed
15.
go back to reference G. Campisi, L.L. Russo, A. Agrillo, P. Vescovi, V. Fusco, A. Bedogni, BRONJ expert panel recommendation of the Italian Societies for Maxillofacial Surgery (SICMF) and Oral Pathology and Medicine (SIPMO) on Bisphosphonate-Related Osteonecrosis of the Jaws: risk assessment, preventive strategies and dental management. Ital. J. Maxillofac. Surg. 22(2), 103–124 (2011) G. Campisi, L.L. Russo, A. Agrillo, P. Vescovi, V. Fusco, A. Bedogni, BRONJ expert panel recommendation of the Italian Societies for Maxillofacial Surgery (SICMF) and Oral Pathology and Medicine (SIPMO) on Bisphosphonate-Related Osteonecrosis of the Jaws: risk assessment, preventive strategies and dental management. Ital. J. Maxillofac. Surg. 22(2), 103–124 (2011)
Metadata
Title
Bisphosphonates in the treatment of HIV-related osteoporosis
Authors
Fabio Vescini
Franco Grimaldi
Publication date
01-03-2015
Publisher
Springer US
Published in
Endocrine / Issue 2/2015
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-014-0488-3

Other articles of this Issue 2/2015

Endocrine 2/2015 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine