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International Journal of Colorectal Disease

Published in:

01-12-2010 | Original Article

Biosutures improve healing of experimental weak colonic anastomoses

Authors: Isabel Pascual, Gemma Fernández de Miguel, Mariano García Arranz, Damián García-Olmo

Published in: International Journal of Colorectal Disease | Issue 12/2010

Abstract

Purpose

Use of biosutures in animal models of colonic anastomoses is associated with decreased adhesions without affecting anastomotic strength. This study aimed to evaluate the effect of biosutures on colonic anastomoses kept free of adhesions by peritoneal instillation of icodextrin 4%.

Methods

Three types of colonic anastomoses were compared: group 1, anastomoses without icodextrin 4% and control suture; group 2, anastomoses with icodextrin 4% (adhesion-free anastomoses) and control suture; and group 3, anastomoses with icodextrin 4% (adhesion-free anastomoses) and biosutures. Dehiscence, adhesion formation, and anastomotic strength were evaluated on day 4 after the operation.

Results

When peritoneal icodextrin 4% was used in anastomoses with conventional sutures, a decrease in the adhesion index (P = 0.01) and a lower bursting pressure (P = 0.15) were observed. When adhesion-free anastomoses were compared, those performed with biosutures had a higher bursting pressure (P = 0.008) and a similar pattern of adhesion index (P = 0.48).

Conclusions

Biosutures improve the strength of adhesion-free colonic anastomoses.

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Title: Biosutures improve healing of experimental weak colonic anastomoses
Authors: Isabel Pascual
Gemma Fernández de Miguel
Mariano García Arranz
Damián García-Olmo
Publication date: 01-12-2010
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 12/2010
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-010-0952-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Biosutures improve healing of experimental weak colonic anastomoses

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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