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Published in: Pediatric Nephrology 7/2018

01-07-2018 | Review

Biomarkers to detect rejection after kidney transplantation

Authors: Vikas R. Dharnidharka, Andrew Malone

Published in: Pediatric Nephrology | Issue 7/2018

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Abstract

Detecting acute rejection in kidney transplantation has been traditionally done using histological analysis of invasive allograft biopsies, but this method carries a risk and is not perfect. Transplant professionals have been working to develop more accurate or less invasive biomarkers that can predict acute rejection or subsequent worse allograft survival. These biomarkers can use tissue, blood or urine as a source. They can comprise individual molecules or panels, singly or in combination, across different components or pathways of the immune system. This review highlights the most recent evidence for biomarker efficacy, especially from multicenter trials.
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Metadata
Title
Biomarkers to detect rejection after kidney transplantation
Authors
Vikas R. Dharnidharka
Andrew Malone
Publication date
01-07-2018
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 7/2018
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-017-3712-6

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