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International Archives of Occupational and Environmental Health

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01-01-2012 | Review

Biomarkers of chromosomal damage in peripheral blood lymphocytes induced by polycyclic aromatic hydrocarbons: a meta-analysis

Authors: Yadong Wang, Haiyan Yang, Li Li, Haiyu Wang, Xiangqun Xia, Congke Zhang

Published in: International Archives of Occupational and Environmental Health | Issue 1/2012

Abstract

Background

A crucial early event in polycyclic aromatic hydrocarbons (PAHs) carcinogenesis is the induction of genomic instability phenotype that initiates the progression of a proliferative cell into a cancer cell. However, epidemiological results have been inconsistent.

Objectives

To assess reported studies of associations between the levels of chromosomal damage including sister chromatid exchange (SCE), chromosomal aberrations (CA), and cytokinesis-block micronucleus (CBMN) in peripheral blood lymphocytes and occupational exposure to PAHs.

Methods

Meta-analysis on the association between chromosomal damage and occupational exposure to PAHs was performed with STATA 10.0 software package and Review Manager 4.2.10 in this study.

Results

We found statistically significant differences in the frequencies of SCE, CBMN, and CA (aberrations per 100 cells) in peripheral blood lymphocytes between PAHs-exposed group and control group, and the summary estimates of weighted mean difference were 1.42 (95% CI: 0.82–2.02), 1.22 (95% CI: 0.33–2.10), and 0.96 (95% CI: 0.37–1.56), respectively.

Conclusions

Data indicate that the frequencies of SCE, CBMN, and CA (aberrations per 100 cells) in peripheral blood lymphocytes might be indicators of early genetic effects for occupationally PAHs-exposed population.

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Title: Biomarkers of chromosomal damage in peripheral blood lymphocytes induced by polycyclic aromatic hydrocarbons: a meta-analysis
Authors: Yadong Wang
Haiyan Yang
Li Li
Haiyu Wang
Xiangqun Xia
Congke Zhang
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: International Archives of Occupational and Environmental Health / Issue 1/2012
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-011-0629-4

At a glance: The STEP trials

Springer Medicine

Biomarkers of chromosomal damage in peripheral blood lymphocytes induced by polycyclic aromatic hydrocarbons: a meta-analysis

Abstract

Background

Objectives

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Objectives

Methods

Results

Conclusions

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