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01-07-2017 | Original Article

Biological relevance of tissue factor and IL-6 in arteriovenous malformations

Authors: Shouhei Noshiro, Takeshi Mikami, Yuko Kataoka-Sasaki, Masanori Sasaki, Kazuo Hashi, Shunya Ohtaki, Masahiko Wanibuchi, Nobuhiro Mikuni, Jeffery D. Kocsis, Osamu Honmou

Published in: Neurosurgical Review | Issue 3/2017

Abstract

Arteriovenous malformations (AVMs) are congenital abnormal vessels that shunt blood directly from the arterial to the venous system without a capillary bed. The underlying pathology of AVMs is not fully understood. The objective of the study was to determine the association between the expression patterns of tissue factor (TF) and interleukin-6 (IL-6) in AVMs with clinical and pathological findings. Eighteen cases of sporadic AVM with operative specimens were included in this study. The expression of messenger RNA (mRNA) of TF and IL-6 was assayed, and association with clinical factors was investigated. The distribution of TF and IL-6 was examined with immunofluorescence. The mRNA expression of TF was significantly higher in AVM specimens than in control tissues (P = 0.002) and significantly higher in the symptomatic group than in the asymptomatic group (P = 0.037). The mRNA expression of IL-6 was likewise significantly higher in AVM specimens than in control tissues (P = 0.038). Examination of immunostained sections indicated that TF⁺ cells were also positive for IL-6 and were distributed around normal endothelial cells and pericytes. Moreover, TF⁺/IL-6⁺ cells also expressed CD31, vascular endothelial growth factor receptor 2 (VEGFR2), and platelet-derived growth factor receptor beta (PDGFR-beta). These results suggest that TF is elevated in AVMs and that it mediates symptomatic events. IL-6 is associated with the angiogenic activity of TF, and both are present in the same abnormal endothelial cells and pericytes. These factors may have interactive effects and may serve in a prognostic role for AVMs.

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Title: Biological relevance of tissue factor and IL-6 in arteriovenous malformations
Authors: Shouhei Noshiro
Takeshi Mikami
Yuko Kataoka-Sasaki
Masanori Sasaki
Kazuo Hashi
Shunya Ohtaki
Masahiko Wanibuchi
Nobuhiro Mikuni
Jeffery D. Kocsis
Osamu Honmou
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: Neurosurgical Review / Issue 3/2017
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-016-0780-1

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Biological relevance of tissue factor and IL-6 in arteriovenous malformations

Abstract

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