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Nutrition & Metabolism
Published in: Nutrition & Metabolism 1/2013

Open Access 01-12-2013 | Review

Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: New perspectives for therapy

Authors: Lela Munjas Jurkić, Ivica Cepanec, Sandra Kraljević Pavelić, Krešimir Pavelić

Published in: Nutrition & Metabolism | Issue 1/2013

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Abstract

Silicon (Si) is the most abundant element present in the Earth's crust besides oxygen. However, the exact biological roles of silicon remain unknown. Moreover, the ortho-silicic acid (H4SiO4), as a major form of bioavailable silicon for both humans and animals, has not been given adequate attention so far. Silicon has already been associated with bone mineralization, collagen synthesis, skin, hair and nails health atherosclerosis, Alzheimer disease, immune system enhancement, and with some other disorders or pharmacological effects. Beside the ortho-silicic acid and its stabilized formulations such as choline chloride-stabilized ortho-silicic acid and sodium or potassium silicates (e.g. M2SiO3; M= Na,K), the most important sources that release ortho-silicic acid as a bioavailable form of silicon are: colloidal silicic acid (hydrated silica gel), silica gel (amorphous silicon dioxide), and zeolites. Although all these compounds are characterized by substantial water insolubility, they release small, but significant, equilibrium concentration of ortho-silicic acid (H4SiO4) in contact with water and physiological fluids. Even though certain pharmacological effects of these compounds might be attributed to specific structural characteristics that result in profound adsorption and absorption properties, they all exhibit similar pharmacological profiles readily comparable to ortho-silicic acid effects. The most unusual ortho-silicic acid-releasing agents are certain types of zeolites, a class of aluminosilicates with well described ion(cation)-exchange properties. Numerous biological activities of some types of zeolites documented so far might probably be attributable to the ortho-silicic acid-releasing property. In this review, we therefore discuss biological and potential therapeutic effects of ortho-silicic acid and ortho-silicic acid -releasing silicon compounds as its major natural sources.
Appendix
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Metadata
Title
Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: New perspectives for therapy
Authors
Lela Munjas Jurkić
Ivica Cepanec
Sandra Kraljević Pavelić
Krešimir Pavelić
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Nutrition & Metabolism / Issue 1/2013
Electronic ISSN: 1743-7075
DOI
https://doi.org/10.1186/1743-7075-10-2

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Nutrition & Metabolism 1/2013 Go to the issue

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Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following acetic acid induced intestinal injury in rats

Review

Mitochondrial-associated metabolic disorders: foundations, pathologies and recent progress

Research

Low serum eicosapentaenoic acid / arachidonic acid ratio in male subjects with visceral obesity

Research

Coffee polyphenols exert hypocholesterolemic effects in zebrafish fed a high-cholesterol diet

Research

Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia

Research

Supplementary site interactions are critical for the regulation of microsomal triglyceride transfer protein by microRNA-30c
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
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Obesity Clinical Trial Summary

At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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