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international journal of stomatology & occlusion medicine
Published in: international journal of stomatology & occlusion medicine 4/2014

01-12-2014 | original article

Biofunctionalization of onplants to enhance their osseointegration

A pilot study in domestic pigs

Authors: Johanna Schmid, Silvia Brunold, Michael Bertl, Hanno Ulmer, Volker Kuhn, Adriano G. Crismani

Published in: international journal of stomatology & occlusion medicine | Issue 4/2014

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Abstract

Background

Onplants are skeletal orthodontic anchorage devices that serve as alternatives to the frequently used miniscrews and palatal implants. Since onplants are not placed in bone, immediate loading is not possible and treatment may be prolonged. The purpose of this study was to improve the onplant surface by nanocrystalline diamond (NCD) coating and bone morphogenetic protein-2 (BMP-2) biofunctionalization to enhance osseointegration.

Materials and methods

Forty-eight onplants were placed on the palate and the mandible of three domestic pigs. The onplants were divided into three groups of the same size: (1) uncoated, (2) coated with NCD, (3) coated with NCD and functionalized with BMP-2. After 6 weeks, the pigs were sacrificed and the samples were subjected to radiographic, histologic, and histomorphometric analyses.

Results

Ten of the 48 onplants were lost. There was no significant difference between the samples in the upper and the lower jaw. The BMP-2 functionalized onplants showed higher bone-to-implant contact than the other groups albeit without significance.

Conclusion

The results of this pilot study show that BMP-2 biofunctionalization of NCD-coated onplants improves osseointegration and may suggest its clinical use in orthodontics. Due to the high loss rate, more investigations are required to confirm the beneficial effects and the current data should be interpreted with caution.
Appendix
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Metadata
Title
Biofunctionalization of onplants to enhance their osseointegration
A pilot study in domestic pigs
Authors
Johanna Schmid
Silvia Brunold
Michael Bertl
Hanno Ulmer
Volker Kuhn
Adriano G. Crismani
Publication date
01-12-2014
Publisher
Springer Vienna
Published in
international journal of stomatology & occlusion medicine / Issue 4/2014
Print ISSN: 1867-2221
Electronic ISSN: 1867-223X
DOI
https://doi.org/10.1007/s12548-014-0116-0

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