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01-11-2008 | Original Paper

Biochemical Mechanism of Healing Activity of the Natural Phenolic, Allylpyrocatechol Against Indomethacin-Induced Gastric Ulceration in Mice

Authors: Debashish Banerjee, Sayanti Bhattacharya, Sandip K. Bandyopadhyay, Subrata Chattopadhyay

Published in: Digestive Diseases and Sciences | Issue 11/2008

Abstract

Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE₂, VEGF, and vWF, along with an increase in endostatin levels. Treatment with the phytochemical allylpyrocatechol (5 mg/kg, p.o. for 3 days) provided significant ulcer healing by reversing these biochemical parameters, as well as increasing the EGF expression more than that observed due to ulceration. Omeprazole (3 mg/kg, p.o. for 3 days) provided a similar healing by improving TAS and mucin levels, without significantly altering the other parameters.

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Title: Biochemical Mechanism of Healing Activity of the Natural Phenolic, Allylpyrocatechol Against Indomethacin-Induced Gastric Ulceration in Mice
Authors: Debashish Banerjee
Sayanti Bhattacharya
Sandip K. Bandyopadhyay
Subrata Chattopadhyay
Publication date: 01-11-2008
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 11/2008
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0266-2

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