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Journal of Natural Medicines
Published in: Journal of Natural Medicines 3-4/2011

01-07-2011 | Note

Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius

Authors: Melfei E. Bungihan, Mario A. Tan, Mariko Kitajima, Noriyuki Kogure, Scott G. Franzblau, Thomas Edison E. dela Cruz, Hiromitsu Takayama, Maribel G. Nonato

Published in: Journal of Natural Medicines | Issue 3-4/2011

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Abstract

Two new benzopyranones, diaportheone A (1) and B (2), were obtained via bioassay-guided isolation of the secondary metabolites from the endophytic fungus Diaporthe sp. P133 isolated from Pandanus amaryllifolius leaves. Their structures were determined from spectral analysis including mass spectrometry, 1D and 2D nuclear magnetic resonance. Both 1 and 2 inhibited the growth of the virulent strain of Mycobacterium tuberculosis H37Rv with minimum inhibitory concentrations of 100.9 and 3.5 μM, respectively.
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Metadata
Title
Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius
Authors
Melfei E. Bungihan
Mario A. Tan
Mariko Kitajima
Noriyuki Kogure
Scott G. Franzblau
Thomas Edison E. dela Cruz
Hiromitsu Takayama
Maribel G. Nonato
Publication date
01-07-2011
Publisher
Springer Japan
Published in
Journal of Natural Medicines / Issue 3-4/2011
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-011-0518-x

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