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01-03-2018 | Original Contribution

Bioactive compounds from regular diet and faecal microbial metabolites

Authors: Tania Fernández-Navarro, Nuria Salazar, Isabel Gutiérrez-Díaz, Borja Sánchez, Patricia Rúas-Madiedo, Clara G. de los Reyes-Gavilán, Abelardo Margolles, Miguel Gueimonde, Sonia González

Published in: European Journal of Nutrition | Issue 2/2018

Abstract

Purpose

Short-chain fatty acids (SCFAs) formation by intestinal bacteria is regulated by many different factors, among which dietary fibre is currently receiving most attention. However, since fibre-rich foods are usually good dietary sources of phenolic compounds, which are also known to affect the microbiota, authors hypothesize that the regular intake of these bioactive compounds could be associated with a modulation of faecal SCFA production by the intestinal microbiota.

Methods

In this work, food intake was recorded by means of a validated Food Frequency Questionnaire. Fibres were determined using Marlett food composition tables, and phenolic compounds were obtained from Phenol-Explorer Database. Analysis of SCFA was performed by gas chromatography–flame ionization/mass spectrometry and quantification of microbial populations in faeces by quantitative PCR.

Results

Klason lignin and its food contributors, as predictors of faecal butyrate production, were directly associated with Bacteroides and Bifidobacterium levels, as well as lignans with Bacteroides. Also, anthocyanidins, provided by strawberries, were associated with faecal propionate and inversely related to Lactobacillus group.

Conclusions

These results support the hypothesis we put forward regarding the association between some vegetable foods (strawberries, pasta, lentils, lettuce and olive oil) and faecal SCFA. More studies are needed in order to elucidate whether these associations have been mediated by the bacterial modulatory effect of the bioactive compounds, anthocyanins, lignans or Klason lignin, present in foodstuffs.

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Title: Bioactive compounds from regular diet and faecal microbial metabolites
Authors: Tania Fernández-Navarro
Nuria Salazar
Isabel Gutiérrez-Díaz
Borja Sánchez
Patricia Rúas-Madiedo
Clara G. de los Reyes-Gavilán
Abelardo Margolles
Miguel Gueimonde
Sonia González
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 2/2018
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1332-8

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